Role of interferon-gamma as a marker of asthma severity and control

Naumov, Denis; Gassan, Dina; Kotova, Olesya; Sheludko, Elizaveta; Afanas’eva, E. Yu.; Perelman, Juliy M.; Shvetcova, Yana

doi:10.1183/13993003.congress-2019.pa4378

Cited by 4 publications

(3 citation statements)

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“…Studies have reported that severe asthma is associated with higher IFN-γ levels. 40 The cellular responses to IFN‐γ are mediated by the IFN-γ receptor (IFNGR), which comprises two chains. Both IFNGR chains lack intrinsic kinase/phosphatase activity and thus rely on JAK1, JAK2 and STAT1 for signal transduction to regulate gene expression, thereby mediating the biological functions of IFN-γ.…”

Section: Discussionmentioning

confidence: 99%

“…IFN-γ, a Th1 cytokine primarily generated by natural killer and activated T cells, is crucial for the induction and regulation of a range of immune responses. Studies have reported that severe asthma is associated with higher IFN-γ levels 40. The cellular responses to IFN‐γ are mediated by the IFN-γ receptor (IFNGR), which comprises two chains.…”

Section: Discussionmentioning

confidence: 99%

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Relationship among genetic variants, obesity traits and asthma in the Taiwan Biobank

Huang

Chu²,

Chen³

et al. 2022

BMJ Open Resp Res

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Background and objectiveObesity and asthma impose a heavy health and economic burden on millions of people around the world. The complex interaction between genetic traits and phenotypes caused the mechanism between obesity and asthma is still vague. This study investigates the relationship among obesity-related polygenic risk score (PRS), obesity phenotypes and the risk of having asthma.MethodsThis is a matched case–control study, with 4 controls (8288 non-asthmatic) for each case (2072 asthmatic). Data were obtained from the 2008–2015 Taiwan Biobank Database and linked to the 2000–2016 National Health Insurance Research Database. All participants were ≥30 years old with no history of cancer and had a complete questionnaire, as well as physical examination, genome-wide single nucleotide polymorphisms and clinical diagnosis data. Environmental exposure, PM2.5, was also considered. Multivariate adjusted ORs and 95% CIs were calculated using conditional logistic regression stratified by age and sex. Mediation analysis was also assessed, using a generalised linear model.ResultsWe found that the obese phenotype was associated with significantly increased odds of asthma by approximately 26%. Four obesity-related PRS, including body mass index (OR=1.07 (1.01–1.13)), waist circumference (OR=1.10 (1.04–1.17)), central obesity as defined by waist-to-height ratio (OR=1.09 (1.03–1.15)) and general–central obesity (OR=1.06 (1.00–1.12)), were associated with increased odds of asthma. Additional independent risk factors for asthma included lower educational level, family history of asthma, certain chronic diseases and increased PM2.5exposure. Obesity-related PRS is an indirect risk factor for asthma, the link being fully mediated by the trait of obesity.ConclusionsObese phenotypes and obesity-related PRS are independent risk factors for having asthma in adults in the Taiwan Biobank. Overall, genetic risk for obesity increases the risk of asthma by affecting the obese phenotype.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Relationship among genetic variants, obesity traits and asthma in the Taiwan Biobank

Huang

Chu²,

Chen³

et al. 2022

BMJ Open Resp Res

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“…Moreover, the model showed increased immune response of type 1 immunity, with increased levels of IFN-γ in the lungs. Clinical studies have reported an association between IFN-γ and asthma severity [ 20 , 21 , 22 , 23 ]. Therefore, although further human clinical studies are needed to verify the results shown here, our mouse model in the present study may imply the influence of severe asthma accompanied by type 1 immunity involved mixed granulocytic phenotype on the gut environment.…”

Section: Discussionmentioning

confidence: 99%

Alteration of Gut Immunity and Microbiome in Mixed Granulocytic Asthma

Rim

Lee

et al. 2022

Biomedicines

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Growing evidence suggests that there is an essential link between the gut and lungs. Asthma is a common chronic inflammatory disease and is considered a heterogeneous disease. While it has been documented that eosinophilic asthma affects gut immunity and the microbiome, the effect of other types of asthma on the gut environment has not been examined. In this study, we utilized an OVA/poly I:C-induced mixed granulocytic asthma model and found increased Tregs without significant changes in other inflammatory cells in the colon. Interestingly, an altered gut microbiome has been observed in a mixed granulocytic asthma model. We observed an increase in the relative abundance of the Faecalibaculum genus and Erysipelotrichaceae family, with a concomitant decrease in the relative abundance of the genera Candidatus arthromitus and Streptococcus. The altered gut microbiome leads to changes in the abundance of genes associated with microbial metabolism, such as glycolysis. We found that mixed granulocytic asthma mainly affects the gut microbial composition and metabolism, which may have important implications in the severity and development of asthma and gut immune homeostasis. This suggests that altered gut microbial metabolism may be a potential therapeutic target for patients with mixed granulocytic asthma.

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