“…The human TNFa gene is located on the chromosomal region 6p21.1-21.3, adjacent to the major histocompatibility complex, and in the neighborhood of genes playing role in the immune system like HLA, Hsp70 or the complement factor C4 (classical pathway) and factor B (alternative pathway). Moreover TNFa -308 is a part of the so-called 8.1 ancestral haplotype (8.1AH), the most frequent ancestral (Appoloni et al, 2004;Ito et al, 2000;Kubota et al, 1998;Mishra, Srivastava, Mittal, Garg, & Mittal, 2013), no primer correlation was found between the genotype and TNFa level in HF population, the above strong and conserved associations between the TNF -308 Moreover ApoAI is a negative acute phase protein, which level decreases in response to inflammation as a part of the acute phase reaction, and it can reflect the grade of inflammation (Khovidhunkit et al, 2004).…”