Role of Immunoglobulin A in COVID-19 and Influenza Infections

Tyagi, Rohit; Basu, Srijani; Dhar, Atika; Gupta, Suman; Gupta, Sneh Lata; Jaiswal, Rishi K.

doi:10.3390/vaccines11111647

Cited by 1 publication

(1 citation statement)

References 31 publications

(31 reference statements)

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“…Therefore, IgA protective activity may account for the clinical results of a less severe (and commonly asymptomatic) COVID-19 course in children and adolescents [64,130,131]. The early specific humoral response constituted by IgA antibodies against SARS-CoV-2 was also detected and persisted in saliva in COVID-19 patients [132,133]. Consequently, these antibodies can be viewed as a particular defensive mechanism and may one day be investigated as a possible diagnostic parameter [134][135][136].…”

Section: Sars-cov-2 Infection Of Oc Is Controlled By Different Factorsmentioning

confidence: 99%

COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic

Bellocchio,

Dipalma,

Inchingolo

et al. 2023

Biomedicines

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and transmission are generally known to be produced by respiratory droplets and aerosols from the oral cavity (O.C.) of infected subjects, as stated by the World Health Organization. Saliva also retains the viral particles and aids in the spread of COVID-19. Angiotensin-converting enzyme Type 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) are two of the numerous factors that promote SARS-CoV-2 infection, expressed by O.C. structures, various mucosa types, and the epithelia of salivary glands. A systemic SARS-CoV-2 infection might result from viral replication in O.C. cells. On the other hand, cellular damage of different subtypes in the O.C. might be associated with various clinical signs and symptoms. Factors interfering with SARS-CoV-2 infection potential might represent fertile ground for possible local pharmacotherapeutic interventions, which may confine SARS-CoV-2 virus entry and transmission in the O.C., finally representing a way to reduce COVID-19 incidence and severity.

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