Immune Reconstitution Inflammatory Syndrome (IRIS) is a major adverse event of antiretroviral therapy (ART) in HIV infection, and paradoxically occurs as HIV viremia is suppressed and CD4 T cell numbers recover. IRIS reflects pathogenic immune responses against opportunistic infections acquired during the period of immunodeficiency, but little is understood about the mechanisms of inflammatory pathology. Here we show that IL-6 and CRP levels transiently rise at the time of the IRIS event in HIV-infected patie…
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