Role of human papillomaviruses in persistent and glucocorticoid‐resistant juvenile phimosis

Pilatz, Adrian; Altinkilic, B.; Rusz, A.; Izykowski, Nicole; Traenkenschuh, Wolfgang; Rische, Johanna; Lehmann, Ulrich; Herbst, C.; Maegel, Lavinia; Becker, Jan U.; Weidner, W.; Jonigk, Danny

doi:10.1111/j.1468-3083.2012.04542.x

Cited by 12 publications

(15 citation statements)

References 29 publications

(101 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this regard, HPV transmission may occur upon contact with infected towels or other objects. In contrast to these findings, Pilatz et al [15] did not find HPV in the foreskin of boys.…”

Section: Hr-hpv Transmission Among Sexual Partnersmentioning

confidence: 75%

“…Models have shown that HPV transmissibility is substantially higher than that of other viral sexually transmitted pathogens [13], but data on the natural history of HPV transmission between heterosexual partners are limited. Many studies [14][15][16][17] analyzed the prevalence and genotypes of high-risk infections of the foreskin before first sexual intercourse found asymptomatic infection in 12-83.3% [14,16], speculating that non-sexual routes play significant roles in HPV transmission. In this regard, HPV transmission may occur upon contact with infected towels or other objects.…”

Section: Hr-hpv Transmission Among Sexual Partnersmentioning

confidence: 99%

See 1 more Smart Citation

Diagnosis and Prevalence of High-Risk Human Papillomavirus Infection in Heterosexual Men

López-Diez¹,

Pérez²,

Iñarrea³

2016

Human Papillomavirus - Research in a Global Perspective

View full text Add to dashboard Cite

A better understanding of human papillomavirus (HPV) infection in men is an essential component of prevention programs aimed to reduce cervical cancer and other HPVrelated diseases. A screening test capable of detecting asymptomatic/subclinical genital HPV infection in men at a reasonable price and causing minimal discomfort to the patient would be very valuable. The following chapter focuses on acetowhite test usefulness in the detection of asymptomatic/subclinical genital high-risk (HR) HPV infection in highrisk men populations, HR-HPV prevalence in sexually active healthy male partners of women diagnosed of high-grade cervical intraepithelial neoplasia and genotypespecific concordance between partners, addressing the preventive strategies that would reduce HPV infection in men. We present data from 125 men, sexual partners of women with preneoplastic cervical lesions. Prevalence of HR-HPV infection in male was high (50, 24% HPV16) and genotype concordance within the 60 infected couples was remarkable (62% shared at least one genotype). Acetowhite (AW) test was positive in 27% patients, showing low sensitivity for the identification of HR-HPV infection but allowed the diagnosis of subclinical HPV-related lesions in more than 10%. Current smoking and genital warts were associated with an increased risk of HR-HPV infection in men (OR: 2.4 and 5.6, respectively).

show abstract

“…In this regard, HPV transmission may occur upon contact with infected towels or other objects. In contrast to these findings, Pilatz et al [15] did not find HPV in the foreskin of boys.…”

Section: Hr-hpv Transmission Among Sexual Partnersmentioning

confidence: 75%

Section: Hr-hpv Transmission Among Sexual Partnersmentioning

confidence: 99%

Diagnosis and Prevalence of High-Risk Human Papillomavirus Infection in Heterosexual Men

López-Diez¹,

Pérez²,

Iñarrea³

2016

Human Papillomavirus - Research in a Global Perspective

View full text Add to dashboard Cite

show abstract

“…The DNA concentration was determined with a Nanodrop 2000 (Thermo Scientific, Wilmington, DE, USA). Per case, 50 ng DNA was analysed with PCR for 32 high-and low-risk HPV (types 6,11,16,18,31,33,35,39,42,44,45,[51][52][53][54]56, 58, 59, 61, 62, 66-68, 70, 72, 73, 81-84, 90, 91) as previously described [28]. A chip-based LCD Array HPV Kit was used according to the manufacturer's instructions (Chipron, Berlin, Germany).…”

Section: Analysis Of Hpv Infectionmentioning

confidence: 99%

Expression of Caspase 14 and Filaggrin in Oral Squamous Carcinoma

Scharenberg

Eckardt

Tiede

et al. 2013

Head and Neck Pathol

View full text Add to dashboard Cite

Caspase 14 is one of the latter discovered members of the caspase enzyme family and, although sharing sequence homologies with the other caspases, it is not involved in apoptosis. Together with its co-factor filaggrin, it plays an important role in skin barrier formation. It is already known that caspase 14 proteins are reduced during neoplastic dedifferentiation in cervical intraepithelial neoplasms and in invasive cervical carcinomas. Oral squamous carcinoma tissues have not been systematically evaluated for caspase 14 expression yet. Formalin-fixed and paraffin-embedded samples from oral squamous carcinomas (n = 36 tumours from 34 patients), metastases (n = 15) and controls (leukoplakia, n = 10) were analysed by immunohistochemistry. In carcinomas, human papilloma virus (HPV) infection was tested by PCR. Here we demonstrate that, in oral epithelia, caspase 14 is expressed mainly by cells of the intermediate and superficial cell layers while filaggrin is expressed only in keratinising foci in leukoplakia. Caspase 14 and filaggrin are co-localised. In invasive oral carcinomas, reduced expression of caspase 14 was detectable in 47 % of tumours but was not associated with keratinisation, tumour differentiation or HPV infection. Filaggrin was detectable in a subfraction of tumours (56 %) and was restricted to keratinising areas of the carcinomas. In summary, in contrast to cervical carcinomas, partial loss of caspase 14 is not associated with dedifferentiation in neoplastic lesions of the oral mucosa or HPV infection.

show abstract

“… 18 Austria 121 NA (0.0–10.0) NA 6, 11, 16, 18 98 55 43 55 NA NA Pilatz et al . 16 Germany 82 4.1 (1.0–14.0) 82 6, 11, 16, 18, 31, 33, 35, 39, 42, 44, 45, 51–54, 56, 58, 59, 61, 62, 66–68, 70, 72, 73, 81–84, 90, 91 0 0 0 0 0 0 Martino et al . 17 Austria 50 5.5 (0.42–15) NA 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 6 6 0 6 6 0 Verit et al .…”

Section: Resultsmentioning

confidence: 99%

HPV prevalence in the foreskins of asymptomatic healthy infants and children: Systematic review and meta-analysis

Lee

Kim

et al. 2017

Sci Rep

View full text Add to dashboard Cite

The true HPV prevalence in the foreskins of infants and children has been little documented, but reporting on this prevalence is of great importance given its impact on the rationale for treating asymptomatic boys. We searched multiple databases from 1960 to 2016 for observational or prospective studies that reported on HPV prevalence in foreskins. We conducted a meta-analysis using a random-effects model to pool for HPV prevalence in the foreskins of infants and children. Eight studies, with a total of 556 infants and children with phimosis, were eligible for the meta-analysis. The pooled overall prevalence of general HPV, high-risk HPV, low-risk HPV, HPV 16/18, HPV 16, and HPV 18 were 17.3 (95%CI: 0.8–46.3), 12.1 (95% CI: 0.9–31.5), 2.4 (95% CI: 0.0–11.2), 4.8 (95% CI: 0.0–16.8), 1.7 (95% CI: 0.0–5.1), and 0 (95% CI: 0–0.5), respectively. The estimated HPV prevalence in foreskins was not zero among infants and children, which implies HPV transmission other than by sexual contact. Considering that high-risk HPV is detected in asymptomatic infants and children, future studies are warranted to determine whether preventive treatments in asymptomatic infants and children could be effective in preventing persistence or transmission of high-risk HPV.

show abstract

Role of human papillomaviruses in persistent and glucocorticoid‐resistant juvenile phimosis

Abstract: Our prospective study has provided evidence that HPV is not usually present in the foreskin of boys with persistent phimosis after their first year of life and that topical glucocorticoid treatment failure is not associated with HPV or any specific histopathological changes.

Cited by 12 publications

References 29 publications

Diagnosis and Prevalence of High-Risk Human Papillomavirus Infection in Heterosexual Men

Diagnosis and Prevalence of High-Risk Human Papillomavirus Infection in Heterosexual Men

Expression of Caspase 14 and Filaggrin in Oral Squamous Carcinoma

HPV prevalence in the foreskins of asymptomatic healthy infants and children: Systematic review and meta-analysis

Contact Info

Product

Resources

About