Role of herpesvirus infection in glomerulonephritis and nephrotic syndrome in children

Нечепоренко, Н. В.; Савенкова, Н. Д.; Калинина, Н. М.

doi:10.21508/1027-4065-2017-62-1-19-25

Cited by 3 publications

(3 citation statements)

References 22 publications

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“…The criteria for reducing antiviral protection were [7][8][9]: 1) a decrease in the absolute number of CD3+ CD8+ (T-cytotoxic lymphocytes) 2) reduction of CD3-CD8+ (activated NK-cells)…”

Section: Resultsmentioning

confidence: 99%

Features of lymphocyte differentiation in ANCA-associated and virus-associated glomerulonephritis in children

Гурина

Dementyeva²,

Степанова³

et al. 2021

Vestnik SPbSU. Medicine

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Glomerulonephritis is a heterogeneous group of immuno-inflammatory diseases. The purpose of the study: to analyze the subpopulation composition of lymphocytes in children with various types of glomerulonephritis. 50 children aged 1 to 16 years were examined: 1 group — 17 children aged 1 to 16 years with ANCA-associated glomerulonephritis; 2 group — 33 patients aged 2 to 16 years with virus-associated glomerulonephritis. Diagnostics of the subpopulation composition of lymphocytes was performed by flow cytometry using non-flushing technology using a three-color combination of monoclonal antibodies. It was found that the development of ANCA-associated glomerulonephritis is accompanied by signs of immunodeficiency against the background of a relative increase in the content of T-lymphocyte subpopulations. Differentiation of lymphocytes in children with virus-associated glomerulonephritis is ambiguous: the process goes either along the path of activation of antiviral protection, or along the path of development of insufficient antiviral activity of immunocytes. In children with virus-associated glomerulonephritis, a decrease in the level of B-lymphocytes was found, correlating with hypoimmunoglobulinemia A, which is an additional factor in reducing resistance on the mucous membranes. The study of lymphocyte differentiation in the development of glomerulonephritis is important for identifying the main immunological mechanisms involved in the pathogenesis of these diseases.

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“…The criteria for reducing antiviral protection were [7][8][9]: 1) a decrease in the absolute number of CD3+ CD8+ (T-cytotoxic lymphocytes) 2) reduction of CD3-CD8+ (activated NK-cells)…”

Section: Resultsmentioning

confidence: 99%

Features of lymphocyte differentiation in ANCA-associated and virus-associated glomerulonephritis in children

Гурина

Dementyeva²,

Степанова³

et al. 2021

Vestnik SPbSU. Medicine

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“…This memory, in turn, has a negative impact on the growth and development of the child, leading to disability [5]. To date, among the etiological causes of chronic glomerulonephritis and nephrotic syndrome in children, the percentage of streptococcal infection has decreased, and at the same time, there are many records of nephropathies of herpesvirus etiology [3]. It is known that herpesviruses (HV) belong to the group of airborne infections [1].…”

Section: Introductionmentioning

confidence: 99%

Clinical Appearance and Treatment Tactics of Herpesvirus Associated Nepropathies in Children

Axmedova¹,

Akalaev²,

Aripxodjaeva³

2022

IJSP

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To date, among the etiological causes of chronic glomerulonephritis in children, the percentage of streptococcal infection has decreased, and at the same time, there are many records of nephropathies of viral etiology. 68 children were examined. Of these, 32 (47%) were children with chronic glomerulonephritis and 36 (53%) with nephrotic syndrome. All sick children underwent clinical, biochemical studies, as well as ELISA and PCR for the diagnosis of herpes infection.Conducted immunoserological studies in the group of children with chronic glomerulonephritis showed the detection of mono-CMV infection in 6.3%, HSV 1/2 +CMV infection in 6.3%, HSV 1/2 +CMV+HHV type 8 in 37.5% of children. In the group of patients with nephrotic syndrome, 10.1% had HSV 1/2 monoinfection, 8.3% had mono-CMV infection, 41.6% had HSV1/2+CMV, and 8.3% had HSV1/2+CMV+HHV 6 type, in 33.3% of HSV1/2+CMV+HHV type 8 mixed infection.

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“…Diagnostics and follow-up of FRNS in children is a big problem due to its heterogeneous etiology, frequent lack of remission in 10-30% of patients in carrying out prolonged immunosuppressive therapy. FRNS is associated with an increased risk of terminal renal failure as well as relapse after kidney transplantation [5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Factors of corticosteroid resistant nephrotic syndrome progression in children

et al. 2020

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Nephrotic syndrome (NS) is one of the most severe kidney pathologies. NS often relapses and becomes resistant to immunosuppressive therapy. In order to identify factors that prevent NS relapses development and possible increase of therapy effectiveness, we have analyzed the course nature of primary (idiopathic) and secondary frequently relapsing steroid-resistant nephrotic syndrome (FRNS) in 22 children who received immunosuppressive therapy (IS) (cyclosporin (CSA) or mycophenolic acid (MPA)). As a result of the study, the following factors of NS progression in observed children were revealed: hereditary predisposition for diseases of urinary system organs; presence of more than 5 small external abnormalities development, greater disease record, presence of herpetic infection and chronic infection focal points. In children with long disease experience, a reliably higher level of proteinuria was identified. At the time of examination, stage I chronic kidney disease was registered in most children, one in five children had stage II CKD. CKD stage was not dependent on the type of immunosuppressive therapy received (p<0.05). For children who had NS activity persistence at the time of the study, it was recommended to re-perform nephrobiopsy in order to verify morphological changes in the kidneys, correction – including the institution of alternative immunosuppressive therapy.

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Role of herpesvirus infection in glomerulonephritis and nephrotic syndrome in children

Cited by 3 publications

References 22 publications

Features of lymphocyte differentiation in ANCA-associated and virus-associated glomerulonephritis in children

Features of lymphocyte differentiation in ANCA-associated and virus-associated glomerulonephritis in children

Clinical Appearance and Treatment Tactics of Herpesvirus Associated Nepropathies in Children

Factors of corticosteroid resistant nephrotic syndrome progression in children

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