Role of hepatic stellate cells in fibrogenesis in a model of pomegranate-treated fatty liver induced by junk food in male albino rats immunohistochemical and electron microscopic study

Hepatoprotective Potential of Pomegranate in Curbing the Incidence of Acute Liver Injury by Alleviating Oxidative Stress and Inflammatory Response

“…PP and PPx (pomegranate peel extract) have been reported for substantial hepato-protection by attenuating inflammatory responses (Bchoual et al, 2011;El-Rashedy et al, 2011). Particularly, a rich variety of PG phenolic compounds such as flavonoids, phenolic acids (Soliman and Selim, 2012;Singh et al, 2017), and tannins has been reported for the hepatoprotective activity against fatty liver disorder (El- Rashedy et al, 2011). Among these compounds, flavonoids are the ones which have a considerable variety of activities such as anti-inflammatory, antidiabetic, anti-allergic, antiplatelet, anti-mutagenic, and antioxidant activities (Xiao, 2017;Khan et al, 2018).…”

Pomegranate action in curbing the incidence of liver injury triggered by Diethylnitrosamine by declining oxidative stress via Nrf2 and NFκB regulation

“…Pomegranate has been well documented in relation to the protective role against liver related diseases such as fatty liver in obesity 14 ; fatty liver induced by junk food 15 . Assortment of various phytochemicals such as polyphenolic constituents-anthocyanins, hydrolysable tannins-ellagitannins & gallotannins and condensed tannins-proanthocyanidin have been found and reported in diverse parts of the fruit 16 .…”

Magnification of the therapeutic uses of pomegranate fruits and peel in rats injected with carbon tetrachloride (Ccl4)

“…Pomegranate fruit contains hundreds of seeds surrounded by red liquid grains called arils, from which pomegranate juice can be prepared or added to the diet in a variety of ways to reap its benefits. Antioxidants are used to treat some diseases such as liver disease and remove toxins from the liver, ( Soliman and Selim, 2012 ) phenolic compounds (such as in pomegranate and cabbage) have reduced the increase in serum levels of AST and ALT. Moreover, POF and POPs affect total bilirubin, direct bilirubin and indirect bilirubin (mg/dl) of hepatitis rats ( Eberhart, 1986 ; Bennett et al, 1995), who discovered that pretreatment with cauliflower flavonoids increased the antioxidant activities of the liver and reduced bilirubin levels when compared to control groups.…”

“…Pomegranate fruit contains hundreds of seeds surrounded by red liquid grains called arils, from which pomegranate juice can be prepared or added to the diet in a variety of ways to reap its benefits. Antioxidants are used to treat some diseases such as liver disease and remove toxins from the liver, ( Soliman and Selim, 2012 ). Additionally, pomegranate leaves are anti-inflammatory and hepatoprotective ( Lansky and Newman, 2007 ).…”