Role of Growth Hormone in Infertility

Jacobs, H. S.; Bouchard, P.; Conway, GS; Homburg, Roy; Lahlou, Najiba; Mason, B.A.; Ostergaard, Hanne L.; Owen, E.J.; Shoham, Zeev

doi:10.1159/000182191

Cited by 14 publications

(4 citation statements)

References 8 publications

(11 reference statements)

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“…In hypophysectomized male rats, administration of GH increases the LH receptor content of the testis [6] and the testicular steroidogenic responsiveness to gonadotropin treatment [7]. In men with hypogonadotropic hypogonadism, treatment with GH and gonadotropin induces sperm production and increases testosterone (T) secretion [8], indicating the critical role of GH in male reproduction. However, it is not known whether GH effects on gonads are mediated through changes in the neuroendocrine system.…”

Section: Introductionmentioning

confidence: 99%

Induction of Endogenous Insulin-Like Growth Factor-I Secretion Alters the Hypothalamic-Pituitary-Testicular Function in Growth Hormone-Deficient Adult Dwarf Mice1

Chandrashekar

Bartke

1993

Biology of Reproduction

100

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To evaluate the influence of growth hormone (GH) on hypothalamic-pituitary-testicular function, GH-deficient adult male Ames dwarf mice were treated (s.c.) twice daily for 8 days with either vehicle or bovine GH (25 micrograms/injection/mouse). Normal male siblings treated with vehicle served as controls. Two in vivo experiments were conducted. In experiment 1, on Day 8, mice were treated (i.p.) with either saline or LHRH (1 ng/g b.w.) in saline. Fifteen minutes later, blood was obtained via heart puncture to assess plasma insulin-like growth factor-I (IGF-I), LH, and testosterone (T) levels by RIAs. In experiment 2, on Day 7, mice were bilaterally castrated and received injections of either oil or T propionate (1 microgram/g b.w.) in oil. Eighteen to twenty hours later, blood was obtained as in experiment 1, and plasma IGF-I and LH levels were determined. In addition to these in vivo experiments, testicular androstenedione and T responses to hCG stimulation in vitro were evaluated. Administration of GH to dwarf mice increased (p < 0.001) plasma IGF-I levels, whereas IGF-I was not detectable in control dwarf mice. Plasma IGF-I concentrations were higher in normal mice than in treated dwarf mice. Basal LH levels were lower (p < 0.025) in dwarf mice than those in normal mice. In dwarf mice, GH treatment increased (p < 0.001) plasma LH levels. The effect of LHRH on LH secretion was increased (p < 0.001) in dwarf mice pretreated with GH, but this LH response was lower than in normal siblings that received vehicle only.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Introductionmentioning

confidence: 99%

Induction of Endogenous Insulin-Like Growth Factor-I Secretion Alters the Hypothalamic-Pituitary-Testicular Function in Growth Hormone-Deficient Adult Dwarf Mice1

Chandrashekar

Bartke

1993

Biology of Reproduction

100

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“…Untreated GHD children often have delayed onset of puberty associated with delayed bone age (de Boer et al ., 1997), while GH replacement in this group has been shown to accelerate the onset of puberty (Darendeliler et al ., 1990). Also, the use of GH as an adjunctive agent to ovulation induction in women with resistance to gonadotrophin treatment led to the suggestion that GH may enhance gonadotrophin action at the level of the ovary (Homburg et al ., 1988, 1990, 1991; Blumenfeld & Lunenfeld, 1989; Blumenfeld, 1991; Jacobs et al ., 1991; Blumenfeld & Amit, 1994; de Boer et al ., 1999). Whether GH also has a direct effect on uterine growth and development has not been fully investigated in humans.…”

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confidence: 99%

Uterus size and ovarian morphology in women with isolated growth hormone deficiency, hypogonadotrophic hypogonadism and hypopituitarism

Tsilchorozidou

Conway

2004

Clinical Endocrinology

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Our findings suggest that GHD might have an independent effect in determining uterus size and therefore the consequences of GHD plus oestrogen deficiency on uterus growth might be additive. The fact that uterine measurements between HH and HP patients did not differed significantly in this study may be explained by the fact that oestrogen replacement has been substituted earlier in the latter group. Furthermore, it appears that standard oestrogen replacement therapy did not result in normal uterine growth. A polycystic ovarian morphology may be a consequence of GH treatment.

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“…Indeed, a few publications by others, and by us, reported that GH co-treatment along FSH or human menopausal gonadotropin/human chorionic gonadotropin (HMG/HCG) might decrease the gonadotropin requirements, duration of ovulation induction, and the daily effective dose of FSH or HMG [8][9][10]. However, it is not only the economic impact of reduction in HMG requirement that is important [3][4][5][6]11].…”

Section: Commentarymentioning

confidence: 99%

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2023

OAJG

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Role of Growth Hormone in Infertility

Cited by 14 publications

References 8 publications

Induction of Endogenous Insulin-Like Growth Factor-I Secretion Alters the Hypothalamic-Pituitary-Testicular Function in Growth Hormone-Deficient Adult Dwarf Mice1

Induction of Endogenous Insulin-Like Growth Factor-I Secretion Alters the Hypothalamic-Pituitary-Testicular Function in Growth Hormone-Deficient Adult Dwarf Mice1

Uterus size and ovarian morphology in women with isolated growth hormone deficiency, hypogonadotrophic hypogonadism and hypopituitarism

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