Role of Glutathione S-Transferase Omega Gene Polymorphisms in Breast-Cancer Risk

Purisa, Wichai; Sangrajrang, Suleeporn

doi:10.1177/030089160909500617

Cited by 11 publications

(6 citation statements)

References 17 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Marahatta et al 14 demonstrated that GSTO1*A140D polymorphism could play an important role for the development of cholangiocarcinoma, breast cancer and hepatocellular carcinoma, and Mohammad Masoudi 26 and his colleagues indicated that GSTO2 NN genotype increase the risk of colorectal cancer. On the contrary, GSTO1 and GSTO2 variants were not associated with breast cancer risk in some study 17 .…”

Section: Discussionmentioning

confidence: 73%

“…In total, 20 articles 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 were identified according to the inclusion and exclusion criteria. The flow chart of literature search and study selection was illuminated in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Among the 20 articles, 5 of them were studies of Caucasian 9 12 15 19 27 , 10 studies were of Asian 10 11 17 18 20 24 25 26 28 29 and the rest were study of different races (white and non-white groups) 13 16 21 22 23 . Cancer cases were all diagnosed histologically or pathologically in these studies.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Genetic polymorphisms in Glutathione S-transferase Omega (GSTO) and cancer risk: a meta-analysis of 20 studies

Wang²,

Yin

et al. 2014

Sci Rep

View full text Add to dashboard Cite

Glutathione S-transferase Omega (GSTO) plays an important role in the development of cancer. Recently, a number of studies have investigated the association between single nucleotide polymorphisms on GSTO and susceptibility to cancer; however, the results remain inconclusive. We performed a meta-analysis of 20 studies, involving 4770 cases and 5701 controls to identify the strength of association by pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs). Overall, the pooled results revealed a significantly increased risk of susceptibility for GSTO2 polymorphism (GG vs. AA: OR = 1.20, 95%CI: 1.02–1.41, Pheterogeneity = 0.116), but no significant association was found for GSTO1 polymorphism. Subgroup analysis showed that GSTO2 polymorphism significantly increased cancer risk in Caucasian population (GG vs. AA: OR = 1.32, 95%CI 1.06–1.64, Pheterogeneity = 0.616) and GSTO2 polymorphism was significantly associated with elevated risk of breast cancer (GG vs. AA OR = 1.37, 95%CI: 1.06–1.77; Pheterogeneity = 0.281). This meta-analysis demonstrates that GSTO2 polymorphism may significantly increase cancer risk in Caucasian population and is associated with elevated risk of breast cancer; while GSTO1 polymorphism is not associated with cancer risk.

show abstract

Section: Discussionmentioning

confidence: 73%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Genetic polymorphisms in Glutathione S-transferase Omega (GSTO) and cancer risk: a meta-analysis of 20 studies

Wang²,

Yin

et al. 2014

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Likewise, Granja et al (11) and Marahatta et al (13) did not fi nd any association between this gene polymorphism and thyroid and colorectal cancers, respectively. Findings are still inconclusive and controversial, as some authors established an increased risk of breast, hepatocellular, bile duct and urothelial cancers, and acute lymphoblastic leukaemia in childhood in GSTO1 A140D mutant allele carries (13,(23)(24)(25) while more recent studies on breast cancer report no such association (36,37).…”

Section: Resultsmentioning

confidence: 99%

Association Between Glutathione S-Transferase Omega 1 A140D Polymorphism in the Turkish Population and Susceptibility to Non-Small Cell Lung Cancer

Ada

Kunak

et al. 2013

Archives of Industrial Hygiene and Toxicology

View full text Add to dashboard Cite

Recent years have seen a growing evidence of ethnic differences in the frequency of glutathione S-transferase omega 1 (GSTO1) A140D gene polymorphism, which is associated with various cancers such as breast and liver. Until now however, no association has been investigated between the GSTO1 A140D polymorphism and lung cancer. The aim of our study was to see if there was one in the Turkish population. To do that, we identifi ed GSTO1 A140D polymorphism in 214 unrelated healthy individuals and 172 patients with non-small cell lung cancer (NSCLC) using the polymerase chain reaction -restriction fragment length polymorphism (PCR-RFLP) method. The frequencies of A/A (wild type), A/D (heterozygous mutant), and D/D (homozygous mutant) GSTO1 A140D genotypes in healthy subjects were 48 %, 41 %, and 11 %, respectively. In NSCLC patients they were 48 %, 45 %, and 7 %, respectively. We found no signifi cant association between the GSTO1 A140D gene polymorphism and NSCLC or its histological subtypes, namely squamous cell carcinoma or adenocarcinoma. Furthermore, this polymorphism did not correlate with smoking. Our study is the fi rst to show that the frequency of GSTO1 A140D gene polymorphism in the Turkish population is similar to other Caucasian populations and that this polymorphism is not associated with susceptibility to NSCLC.

show abstract

“…On the basis of the literature search, 33 of the 47 identified proteins have been reported clearly relating to cancer. For example, several proteins such as glutathione S -transferase omega, glyoxalase 1, , HMGB1, , profilin 1, , HSP70, , PRDX1, , annexin 1, , transgelin and keratin 19 , were reported relating to breast cancer; keratin 17 was involved in tumor angiogenesis; Biliverdin reductase B (BVRB) was overexpressed in liver cancer; smooth muscle protein 22 was reported relating to gastric cancer and renal cell carcinoma; , cystatin B was characterized as either a tissue and urinary biomarker in bladder cancer or serological marker in liver cancer, and the reduced expression of stratifin may use as a marker for prognosis of ESCC . More recently, the overexpression of PRDX1 was also reported in prostate cancer cell lines compared with nontumor cells .…”

Section: Resultsmentioning

confidence: 99%

Using Proteomic Approach to Identify Tumor-Associated Proteins as Biomarkers in Human Esophageal Squamous Cell Carcinoma

et al. 2011

View full text Add to dashboard Cite

Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers in China. The lower survival rate of ESCC is attributed to late diagnosis and poor therapeutic efficacy; therefore, the identification of tumor-associated proteins as biomarkers for early diagnosis, and the discovery of novel targets for therapeutic intervention, seems very important for increasing the survival rate of ESCC. To identify tumor-associated proteins as biomarkers in ESCC, we have analyzed ESCC tissues and adjacent normal tissues by two-dimensional electrophoresis (2DE) and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS) analysis. The results showed that a total of 104 protein spots with different expression levels were found on 2DE, and 47 proteins were eventually identified by MALDI-TOF MS. Among these identified proteins, 33 proteins including keratin 17 (KRT17), biliverdin reductase B (BLVRB), proteasome activatorsubunit 1 (PSME1), manganese superoxide dismutase (MnSOD), high-mobility group box-1(HMGB1), heat shock protein 70 (HSP70), peroxiredoxin (PRDX1), keratin 13 (KRT13), and so on were overexpressed, and 14 proteins including cystatin B (CSTB), tropomyosin 2 (TPM2), annexin 1 (ANX1), transgelin (TAGLN), keratin 19 (KRT19), stratifin (SFN), and so on were down-expressed in ESCC. Biological functions of these proteins are associated with cell proliferation, cell motility, protein folding, oxidative stress, and signal transduction. In the subsequent study using immunoassay on ESCC serum samples and tissue-array slides, two representative proteins, HSP70 and HMGB1, were selected as examples for the purpose of validation. The results showed that both HSP70 and HMGB1 can induce autoantibody response in ESCC sera and have higher expression in ESCC tissues. Especially, the frequency of antibodies to HSP70 in ESCC sera was significantly higher than that in normal human sera. The preliminary results suggest that some of these identified proteins might contribute to esophageal cell differentiation and carcinogenesis, certain proteins could be used as tumor-associated antigen (TAA) biomarkers in cancer diagnosis, and further studies on these identified proteins should provide more evidence of how these proteins are involved in carcinogenesis of ESCC.

show abstract

Role of Glutathione S-Transferase Omega Gene Polymorphisms in Breast-Cancer Risk

Abstract: The results of the study suggest that GSTO1 and GSTO2 variants are not associated with breast cancer risk, but that wild-type GSTO1 (A140/A140) is likely among cases at an advanced stage.

Cited by 11 publications

References 17 publications

Genetic polymorphisms in Glutathione S-transferase Omega (GSTO) and cancer risk: a meta-analysis of 20 studies

Genetic polymorphisms in Glutathione S-transferase Omega (GSTO) and cancer risk: a meta-analysis of 20 studies

Association Between Glutathione S-Transferase Omega 1 A140D Polymorphism in the Turkish Population and Susceptibility to Non-Small Cell Lung Cancer

Using Proteomic Approach to Identify Tumor-Associated Proteins as Biomarkers in Human Esophageal Squamous Cell Carcinoma

Contact Info

Product

Resources

About