Role of glutamine administration on cellular immunity after total parenteral nutrition enriched with glutamine in patients with systemic inflammatory response syndrome

Cetinbas, F; Yelken, Birgül; Gülbaş, Zafer

doi:10.1016/j.jcrc.2010.03.011

Cited by 50 publications

(32 citation statements)

References 11 publications

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“…In this study, endotoxin and TNF-α levels in the observation group were significantly improved compared with those in the control group, indicating that glutamine can reduce the postoperative inflammatory response and side-effects. This result is consistent with the finding of Cetinbas et al (27). Glutamine is the most abundant amino acid in cells and human body.…”

Section: Discussionsupporting

confidence: 94%

“…Under normal circumstances, glutamine has the characteristics of non-essential amino acids. Glutamine, which is important for the catabolic acceleration process, can improve metabolism of the intestinal mucosal cells; glutamine can promote the rapid synthesis of GSH substances, and further strengthen the body's antioxidant capacity (27). At the same time, as raw materials and nitrogen donor of nucleotide precursor, glutamine can greatly promote the differentiation and proliferation of macrophages and lymphocyte, increase the synthesis of phospholipid mRNA, and inhibit TNF-α over-production, and thus effectively improve immune function.…”

Section: Discussionmentioning

confidence: 99%

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Effects of glutamine on cytokines 1L‑1 and TNF‑α in rehabilitation and prognosis of patients with lobectomy

Wang

Huang

et al. 2018

Exp Ther Med

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This study was designed to investigate the effects of glutamine on cytokines 1L-1, TNF-α and prognosis of patients with lobectomy in the process of postoperative rehabilitation. A total of 78 patients with lung cancer who underwent lobectomy from January 2015 to January 2017 were selected in Daqing Oilfield General Hospital (Daqing, China). Patients were randomly divided into two groups, 39 patients in each group. Patients in the control group were treated with conventional treatment, while patients in the observation group were treated with both conventional and glutamine treatment. The levels of TNF-α, endotoxin, serum IL-1, IL-10, IL-15, IL-18 and intercellular adhesion molecule-1 (ICAM-1), myeloperoxidase (MPO) activity, incidence of nausea and vomiting, pulmonary histopathological changes, prognosis, and rehabilitation (time in bed, hospital stay and lung function) were compared between the two groups. Within 1 year after treatment, most patients survived, except 2 patients in the observation group and 3 patients in the control group who died. The rate of postoperation infection in the observation group was slightly lower than that in the control group. After treatment, the levels of endotoxin and TNF-α in the observation group were significantly lower than those in the control group (p<0.05). After treatment, the serum levels of IL-1 and IL-10 were significantly higher and the serum levels of IL-15 and IL-18 were significantly lower in the observation group than those in the control group (p<0.05). The expression levels of ICAM-1 and MPO activity were significantly higher in the observation group than those in the control group (p<0.05). No significant difference in the incidence of nausea and vomiting was found between the two groups (p>0.05). The average postoperative bed rest and hospital stay in the observation group were significantly shorter than those in the control group (p<0.05). The levels of forced expiratory volume in 1 sec (FEV1), forced vital capacity (FVC) and peak expiratory flow rate (PEFR) in the observation group were significantly higher than those in the control group (p<0.05). The results indicated that glutamine treatment is effective in the postoperative rehabilitation of patients undergoing lobectomy. Glutamine can regulate the levels of IL-1 and TNF-α, improve lung function, shorten bed rest and hospitalization days, promote patients postoperative rehabilitation process, and improve patients quality of life.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Effects of glutamine on cytokines 1L‑1 and TNF‑α in rehabilitation and prognosis of patients with lobectomy

Wang

Huang

et al. 2018

Exp Ther Med

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“…Glutamine is known to affect the number and function of T lymphocytes, and their subgroups (helper T lymphocytes, cytotoxic T lymphocytes) in humans (68), mice (69), and rats (70). Unfortunately, there has been no further investigation into the effects of glutamine on subgroups of helper T lymphocytes, including Th1, Th2, Th17, and Tregs.…”

Section: Glutamine and Generation Of Intestinal Sigamentioning

confidence: 99%

Glutamine-Induced Secretion of Intestinal Secretory Immunoglobulin A: A Mechanistic Perspective

et al. 2016

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Secretory immunoglobulin A (SIgA) is one important line of defense in the intestinal mucosal surface to protect the intestinal epithelium from enteric toxins and pathogenic microorganisms. Multiple factors, such as intestinal microbiota, intestinal cytokines, and nutrients are highly involved in production of SIgA in the intestine. Recently, glutamine has been shown to affect intestinal SIgA production; however, the underlying mechanism by which glutamine stimulates secretion of intestinal SIgA is unknown. Here, we review current knowledge regarding glutamine in intestinal immunity and show that glutamine-enhanced secretion of SIgA in the intestine may involve intestinal microbiota, intestinal antigen sampling and presentation, induction pathways for SIgA production by plasma cells (both T-dependent and T-independent pathway), and even transport of SIgA. Altogether, the glutamine-intestinal SIgA axis has broad therapeutic implications for intestinal SIgA-associated diseases, such as celiac disease, allergies, and inflammatory bowel disease.

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“…It does not possess an antioxidant effect on its own. However, it has been shown to protect cells and tissues against a variety of stressful stimuli including inflammation [7,8,9], ischemia [10,11,12], infection, fibrosis and cancer [13,14,15,16]. …”

Section: Introductionmentioning

confidence: 99%

Preconditioning with Glutamine Protects against Ischemia/Reperfusion-Induced Hepatic Injury in Rats with Obstructive Jaundice

Dai

Peng

et al. 2014

Pharmacology

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Objective: To ascertain whether glutamine (Gln) pretreatment protects rats with obstructive jaundice from hepatic ischemia/reperfusion (I/R) injury and to determine the underlying molecular mechanisms. Methods: An obstructive jaundice rat model was developed by bile duct ligation. On the first day after the operation, all rats were randomized into two groups and received oral Gln or normal saline (NS) daily for 7 days. Then both groups underwent a 15-min liver ischemia via the Pringle maneuver. Blood samples as well as liver and intestinal tissues were harvested and measured after 1, 6 and 24 h of reperfusion. Results: The results showed that the histological morphology of the liver and intestinal tissues significantly improved in the Gln group after I/R injury compared with the NS group. Serum proteins and enzymes associated with hepatic function also significantly improved in the Gln group. The level of glutathione increased and the levels of malondialdehyde and myeloperoxidase decreased in the Gln group. The levels of interleukin-1β and tumor necrosis factor-α decreased in the Gln group. Moreover, bcl-2 protein expression was upregulated and intercellular adhesion molecule 1 and bax protein expression downregulated in the Gln group; the caspase 3 mRNA level significantly increased in the Gln group. Conclusions: The study demonstrates that preconditioning with Gln significantly improves hepatic structure and function after I/R injury in rats with obstructive jaundice. The protective effect of Gln was mediated by the inhibition of reactive oxygen species and inflammation as well as a reduction in hepatocyte apoptosis.

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Role of glutamine administration on cellular immunity after total parenteral nutrition enriched with glutamine in patients with systemic inflammatory response syndrome

Cited by 50 publications

References 11 publications

Effects of glutamine on cytokines 1L‑1 and TNF‑α in rehabilitation and prognosis of patients with lobectomy

Effects of glutamine on cytokines 1L‑1 and TNF‑α in rehabilitation and prognosis of patients with lobectomy

Glutamine-Induced Secretion of Intestinal Secretory Immunoglobulin A: A Mechanistic Perspective

Preconditioning with Glutamine Protects against Ischemia/Reperfusion-Induced Hepatic Injury in Rats with Obstructive Jaundice

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