Role of fibroscan and APRI in detection of liver fibrosis: A systematic review and meta-analysis

Concordance of transient elastography and shear wave elastography for measurement of liver stiffness

“…1 Liver injury arises from a wide range of causes such as alcohol and drug abuse, viral hepatitis, medications and obesity that cause excessive accumulation of extracellular matrix proteins within the liver parenchyma leading to fibrosis and eventually cirrhosis. 2 Historically, the gold standard for determining the degree of fibrosis was liver biopsy; which can be painful, expensive, has a risk of haemorrhage and requires assessment by a pathologist. 3 Furthermore, liver biopsy is limited by significant sampling bias as only 1/50 000 of the total liver volume is assessed.…”

Noninvasive diagnosis of cirrhosis: A review of different imaging modalities

“…It must be noted that the newest release of the Siemens ARFI system is based on two acoustic pulses, and the maximum depth nowadays achievable is 8 cm, so the more recent published data should be more indicative of what can be obtainable. Moreover, high variability in normal values has been reported; for example, in both [53] 13 Various -89% 87% -Shaheen et al [107] 4 HCV 12.5 86% 93% 0.95 Talwalkar et al [108] 9 Various -87% 91% -Friedrich-Rust et al [109] 50 Various ---0.94 Tsochatzis et al [110] 40 HCV 15 ± 4.1 83% 89% -Adebajo et al [111] 5 HCV -98% 84% -Stebbing et al [112] 22 Various 15.08 84.45% 94.69% -Abd El Rihim et al [113] 23 Various -83.40% 92.40% -Chon et al [114] 18 in diagnosing the onset of fibrosis in NAFLD and nonalcoholic steatohepatitis (NASH), in which B-mode evaluation can be inaccurate; Fierbinteanu-Braticevici et al [50] reported a high diagnostic performance in predicting cirrhosis in these patients (AUROC = 0.984). Most studies report at least equivalence between TE and ARFI: Friedrich-Rust et al [51] (AUROCs of 0.91 and 0.91 for cirrhosis), Piscaglia et al [37] (high correlation, r = 0.891), Vermehren et al [52] (r = 0.75, P < 0.001), Bota et al [53] (mean difference in rDOR = 0.12), Cassinotto et al [54] (no significant difference).…”

Incorporation of Noninvasive Measures of Liver Fibrosis Into Clinical Practice: Diagnosis and Prognosis

“…If non-invasive markers are expected to supplant liver biopsies in a significant number of cases, one needs to be vigilant that problems associated with liver biopsy (morbidity, misclassification, inter-observer and sampling variability with liver biopsy) are not traded for another (misclassification, overestimation of liver fibrosis, operator inexperience, unreliable and incomplete examinations). .84 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 127 Ayman Yosry 5871 (20) 0.5 81 80 n/a n/a n/a n/a M A N U S C R I P T…”