“…We have reported previously that, in fetuses with congenital CMV infection without structural anomalies detected on prenatal imaging, the risk of symptomatic infection and long-term sequelae related to the infection is lower compared with that reported in studies not considering the role of fetal imaging in predicting the prognosis 23 . Conversely, the presence of ultrasound or MRI anomalies, mainly those affecting the brain, represents the main risk factors for symptomatic disease and adverse perinatal outcome 24,25 . In the present review, we did not observe that prenatal valacyclovir therapy improved the prognosis of fetuses once congenital infection has been established.…”