Role of epidermal stem cells in repair of partial-thickness burn injury after using Moist Exposed Burn Ointment (MEBO®) histological and immunohistochemical study

Epidermal Stem Cells in Wound Healing and Regeneration

“…EpiSCs express mainly keratin 15 and 19 (CK15 and CK19); TACs express keratin 5 and 14 (CK5 and CK14); and TDCs express keratin 1 and 10 (CK1 and CK10). Some scholars [32,33] conducted doublelabeling experiments, showing that cells with positive expression of CK19 had the following characteristics: (1) cells with positive expression of CK19 were (3H) label-retaining cells with slow-cycle characteristics of stem cells and (2) the expression of β1 integrin for cells with positive expression of CK19 was also positive, indicating that CK19 could be used as a specific marker for EpiSCs [34,35]. Lyle et al [36] found that EpiSCs in the hair follicle bulge showed high expression of CK15, and in the process of EpiSCs differentiation, the decrease in CK15 expression occurred earlier than the decrease in CK19 expression.…”

External Application of Traditional Chinese Medicine for Venous Ulcers: A Systematic Review and Meta-Analysis

“…Therefore, a substantial amount of research has investigated the chemical constituents of EA-TCMs. Moist exposed burn ointment, the most representative EA-TCM, has pharmacological effects that include prevention of dermal water loss, as well as anti-inflammatory, antibacterial, and analgesic properties [ 29 – 31 ]. ShengJiYuHong ointment has been shown to inhibit inflammatory responses by acting on the inflammatory mediators and cells and to improve wound healing by promoting fibroblast proliferation and tissue granulation [ 32 – 34 ].…”

Clinical efficacy of utilizing Ultrapulse CO2 combined with fractional CO2 laser for the treatment of hypertrophic scars in Asians—A prospective clinical evaluation

“…MEBO is a wound ointment (Shantou MEBO Pharmaceutical Co., Ltd.) (Figure ) and is topically applied as a 1‐mm film with no occlusive dressings. The benefits of MEBO have been reviewed elsewhere . The ointment is changed every 3‐4 hours by padding the affected area dry with cotton buds or clean paper towels.…”