Infectious Disease Clinics of North America volume 20, issue 4, P913-929 2006 DOI: 10.1016/j.idc.2006.09.008 View full text
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Ines Colmegna, Robert F. Garry

Abstract: Molecular epidemiologic proof that HERVs and other retroelements are involved in autoimmunity or other disorders is complicated by their large numbers in the human genome. As discussed, most HERVs are no longer functional or active because of the accumulation of mutations, frameshifts, and deletions. Detection or quantification of HERV transcripts that may be pathologically involved in a particular autoimmune disease thus is often compromised by the presence in great excess of related, but nonfunctional, RNA. …

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