Role of dried blood spots in health and disease diagnosis in older adults

Tarik, Mohamad; Abraham, Ransi Ann

doi:10.4155/bio.14.242

Cited by 15 publications

(9 citation statements)

References 66 publications

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“…Other areas where DBS has been embraced include health outcome and public health studies, measurements of physiological response, diagnostic markers, environmental contaminants, pathogens, etc. (Brindle, O'Connor, & Garrett, ; Calafat & Kato, ; Lakshmy, Tarik, & Abraham, ; Parker & Cubitt, ).…”

Section: Discussionmentioning

confidence: 99%

Review of DBS methods as a quantitative tool for anticancer drugs

Sulochana

Daram

Srinivas

et al. 2018

Biomedical Chromatography

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An overview of published dried blood spot (DBS) methods for the quantitation of various classes of anticancer drugs from clinical and preclinical studies is presented. The increased reporting of DBS methods in the literature for quantitation of various classes of drugs is a testimony to their utility in bioanalytical applications. While DBS offers several advantages as compared with conventional wet sampling techniques, there remain a number of nuances that may impede the assay adaptability of DBS method in routine quantitative bioanalysis. This review covers several case studies of DBS application in the quantitation of anticancer drugs. Some perspectives are provided on the optimization of the DBS method with respect to the selection of DBS card, spot volume, hematocrit effect and other regular validation parameters, which are essential in quantitative bioanalysis. Some thoughts are provided on the existing gaps in the DBS method and possible remedial measure(s) to address such gaps.Although DBS methods have great potential, there is the need for a global consensus including regulatory support on the type of validation experiments to be performed to support quantitative data.

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Section: Discussionmentioning

confidence: 99%

Review of DBS methods as a quantitative tool for anticancer drugs

Sulochana

Daram

Srinivas

et al. 2018

Biomedical Chromatography

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“…This is a time-consuming process that requires well-trained personnel. Recent technological developments allow us to conduct food intake biomarker analyses with high sensitivity requiring very small blood volumes or tissue samples (54)(55)(56) . Combining these novel and sensitive techniques with non-professional biological sampling (e.g.…”

Section: Application Of New Food Metabolomics Techniques In (Acute) Imentioning

confidence: 99%

Combining traditional dietary assessment methods with novel metabolomics techniques: present efforts by the Food Biomarker Alliance

et al. 2017

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FFQ, food diaries and 24 h recall methods represent the most commonly used dietary assessment tools in human studies on nutrition and health, but food intake biomarkers are assumed to provide a more objective reflection of intake. Unfortunately, very few of these biomarkers are sufficiently validated. This review provides an overview of food intake biomarker research and highlights present research efforts of the Joint Programming Initiative 'A Healthy Diet for a Healthy Life' (JPI-HDHL) Food Biomarkers Alliance (FoodBAll). In order to identify novel food intake biomarkers, the focus is on new food metabolomics techniques that allow the quantification of up to thousands of metabolites simultaneously, which may be applied in intervention and observational studies. As biomarkers are often influenced by various other factors than the food under investigation, FoodBAll developed a food intake biomarker quality and validity score aiming to assist the systematic evaluation of novel biomarkers. Moreover, to evaluate the applicability of nutritional biomarkers, studies are presently also focusing on associations between food intake biomarkers and diet-related disease risk. In order to be successful in these metabolomics studies, knowledge about available electronic metabolomics resources is necessary and further developments of these resources are essential. Ultimately, present efforts in this research area aim to advance quality control of traditional dietary assessment methods, advance compliance evaluation in nutritional intervention studies, and increase the significance of observational studies by investigating associations between nutrition and health.

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“…A circular punch (about 3 mm) is removed, eluted, and analyzed for metabolic markers. More than 50 separate analytes can be measured from a quarter of a blood spot [ 17 , 18 ], mainly due to adoption within the last decades of the high sensitivity of liquid chromatography (LC) combined with mass spectrometry (MS) ( http://vitas.no/services/dried-blood-spots ).…”

Section: Dbs Technologymentioning

confidence: 99%

“…There are rather few studies using DBS in studies of older individuals [ 17 ]. Vitamin D status of seniors (> 60 years old, average age 72 years) was studied in 224 subjects in the ethnically diverse Older Adult Centre in Toronto [ 122 ].…”

Section: Dbs Profiling Of Vitamins a And Dmentioning

confidence: 99%

Biomarkers for nutrient intake with focus on alternative sampling techniques

et al. 2016

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Biomarkers of nutrient intake or nutrient status are important objective measures of foods/nutrients as one of the most important environmental factors people are exposed to. It is very difficult to obtain accurate data on individual food intake, and there is a large variation of nutrient composition of foods consumed in a population. Thus, it is difficult to obtain precise measures of exposure to different nutrients and thereby be able to understand the relationship between diet, health, and disease. This is the background for investing considerable resources in studying biomarkers of nutrients believed to be important in our foods. Modern technology with high sensitivity and specificity concerning many nutrient biomarkers has allowed an interesting development with analyses of very small amounts of blood or tissue material. In combination with non-professional collection of blood by finger-pricking and collection on filters or sticks, this may make collection of samples and analyses of biomarkers much more available for scientists as well as health professionals and even lay people in particular in relation to the marked trend of self-monitoring of body functions linked to mobile phone technology. Assuming standard operating procedures are used for collection, drying, transport, extraction, and analysis of samples, it turns out that many analytes of nutritional interest can be measured like metabolites, drugs, lipids, vitamins, minerals, and many types of peptides and proteins. The advantage of this alternative sampling technology is that non-professionals can collect, dry, and mail the samples; the samples can often be stored under room temperature in a dry atmosphere, requiring small amounts of blood. Another promising area is the potential relation between the microbiome and biomarkers that may be measured in feces as well as in blood.

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Role of dried blood spots in health and disease diagnosis in older adults

Cited by 15 publications

References 66 publications

Review of DBS methods as a quantitative tool for anticancer drugs

Review of DBS methods as a quantitative tool for anticancer drugs

Combining traditional dietary assessment methods with novel metabolomics techniques: present efforts by the Food Biomarker Alliance

Biomarkers for nutrient intake with focus on alternative sampling techniques

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