Role of Cyclooxygenase Inhibitors in Diminution of Dissimilar Stress-induced Depressive Behavior and Memory Impairment in Rats

Perveen, Tahira; Emad, Shaista; Haider, Saida; Sadaf, Sana; Qadeer, Sara; Batool, Zehra; Sarfaraz, Yousra; Sheikh, Sheeza

doi:10.1016/j.neuroscience.2017.11.014

Cited by 9 publications

(12 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is well documented that an imbalance between pro-oxidant and antioxidant causes various diseases such as anxiety and depression [ 48 ]. The natural cellular antioxidant enzyme SOD, CAT, and GPx fight against ROS production [ 49 ] and produce protective effects against various threats/diseases [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Behavioral and Biochemical Effects of Mukia madrespatana Following Single Immobilization Stress on Rats

et al. 2020

View full text Add to dashboard Cite

Background and Objectives: Elevated oxidative stress has been shown to play an important role in the diagnosis and prognosis of stress and memory-related complications. Mukia madrespatana (M. madrespatana) has been reported to have various biological and antioxidant properties. We intended to evaluate the effect of M. madrespatana peel on single immobilization stress-induced behavioral deficits and memory changes in rats. Materials and Methods: M. madrespatana peel (2000 mg/kg/day, orally) was administered to control and immobilize stressed animals for 4 weeks. Anxiolytic, antidepressant, and memory-enhancing effects of M. madrespatana were observed in both unstressed and stressed animals. Results: Lipid peroxidation was decreased while antioxidant enzymes were increased in both unstressed and stressed animals. Acetylcholine level was increased while acetylcholinesterase activity was decreased in both M. madrespatana treated unstressed and stressed rats. There was also an improvement in memory function. Serotonin neurotransmission was also regulated in M. madrespatana treated rats following immobilization stress with anxiolytic and anti-depressive effects. Conclusion: Based on the current study, it is suggested that M. madrespatana has strong antioxidant properties and may be beneficial as dietary supplementation in stress and memory-related conditions.

show abstract

Section: Discussionmentioning

confidence: 99%

Behavioral and Biochemical Effects of Mukia madrespatana Following Single Immobilization Stress on Rats

et al. 2020

View full text Add to dashboard Cite

show abstract

“…On the contrary Mesripour et al (2019) found indomethacin to reverse FST-induced despair and improve IFN-α induced despair and anhedonia in male albino mice. Perveen et al (2018) also found indomethacin to reverse FST induced despair and CMS induced despair in male S-D rats. Stachowicz (2020) reported indomethacin not to affect FST or TST induced despair but to improve the antidepressant effect of imipramine when given in combination in CD1 and C57/BL6 mice.…”

Section: Resultsmentioning

confidence: 75%

“… Borges et al (2014) found diclofenac to reduce monoarthritis-induced despair in male S-D rats, and De La Garza et al (2005) showed the same for LPS induced despair in male Wistar rats. Perveen et al (2018) reported that diclofenac reduced FST- and stress-induced despair in male S-D rats.…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen studies examined the antidepressant effects of the NSAID in the FST without further manipulations of the animals ( Yamano et al, 2000 ; Deak et al, 2005 ; Warner-Schmidt et al, 2011 ; Guan et al, 2014 ; Santiago et al, 2014 ; Norden et al, 2015 ; Perveen et al, 2018 ; Qadeer et al, 2018 ; Mesripour et al, 2019 ; Song et al, 2019 ; Stachowicz, 2020 ; Pavlock et al, 2021 ; Salmani et al, 2021 ). ASA, Celecoxib, ibuprofen, piroxicam, and indomethacin were shown to have antidepressant effects ( Guan et al, 2014 ; Santiago et al, 2014 ; Perveen et al, 2018 ; Mesripour et al, 2019 ; Salmani et al, 2021 ). Other studies showed no antidepressant effects in the FST of ibuprofen, celecoxib, indomethacin, ASA or naproxen ( Yamano et al, 2000 ; Warner-Schmidt et al, 2011 ; Norden et al, 2015 ; Qadeer et al, 2018 ; Song et al, 2019 ; Stachowicz, 2020 ; Pavlock et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Antidepressant Effects of NSAIDs in Rodent Models of Depression—A Systematic Review

Bay-Richter

Wegener

2022

Front. Pharmacol.

View full text Add to dashboard Cite

In recent years much focus has been on neuroimmune mechanisms of depression. As a consequence, many preclinical and clinical trials have been performed examining potential antidepressant effects of several anti-inflammatory drugs. The results of such trials have been varied. With the current manuscript we wished to elucidate the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on depressive-like behaviour in rodent models of depression by performing a systematic review of the available literature. We performed a systematic literature search in PubMed for rodent models of depression where NSAIDs were administered and a validated measure of depressive-like behaviour was applied. 858 studies were initially identified and screened using Covidence systematic review software. Of these 36 met the inclusion criteria and were included. The extracted articles contained data from both rat and mouse studies but primarily male animals were used. Several depression models were applied and 17 different NSAIDs were tested for antidepressant effects. Our results suggest that stress models are the best choice when examining antidepressant effects of NSAIDs. Furthermore, we found that rat models provide a more homogenous response than mouse models. Intriguingly, the use of female animals was only reported in three studies and these failed to find antidepressant effects of NSAIDs. This should be explored further. When comparing the different classes of NSAIDs, selective COX-2 inhibitors were shown to provide the most stable antidepressant effect compared to non-selective COX-inhibitors. Suggested mechanisms behind the antidepressant effects were attenuation of neuroinflammation, HPA-axis dysregulation and altered monoamine expression.

show abstract

“…Ïðè èññëåäîâàíèè ñíèaeåíèÿ ðàçëè÷íûõ ñòðåññ-èíäóöèðîâàííûõ ðàññòðîéñòâ ïàìÿòè âîçäåéñòâèåì ÍÏÂÑ ïîêàçàíî èõ çíà÷èòåëüíîå âëèÿíèå íà ñíèaeåíèå óðîâíÿ êîðòèêîñòåðîíà â ïëàçìå è óâåëè÷åíèå äîôàìèíà è ñåðîòîíèíà. Ýòî èññëåäîâàíèå ïðîäåìîíñòðè- ðîâàëî òåðàïåâòè÷åñêèé ïîòåíöèàë ÍÏÂÑ äëÿ êîððåêöèè ñòðåññ-èíäóöèðîâàííûõ íàðóøåíèé ôóíêöèé ïàìÿòè è ñâÿçàííûõ ñ íèìè ãîðìîíàëüíûõ è íåéðîõèìè-÷åñêèõ èçìåíåíèé â ãîëîâíîì ìîçãå êðûñ [53]. Ïðè íåéðîäåãåíåðàöèè, öåðåáðîâàñêóëÿðíîé ïàòîëîãèè è ñòðåññ-èíäóöèðîâàííûõ ðàññòðîéñòâàõ êîãíèòèâíûõ ôóíêöèé ïîçèòèâíûé ýôôåêò ÍÏÂÑ ìîaeåò áûòü ñâÿçàí è ñ âëèÿíèåì ýòèõ ïðåïàðàòîâ íà ïðîöåññû íåéðîãåíåçà: ÍÏÂÑ ñòèìóëèðóþò íåéðîãåíåç â ãèïïîêàìïàëüíîé íåéðîãåííîé íèøå, ñíèaeàþò ïðîÿâëåíèÿ íåéðîâîñïàëåíèÿ, ïðåïÿòñòâóþùåãî ýôôåêòèâíîìó íåéðîãåíåçó [6].…”

Section: òå÷åíèå áåðåìåííîñòè è çàìåäëåíèå ðîäîâîé äåÿòåëüíîñòèunclassified

Нестероидные Противовоспалительные Средства: Ключевые Механизмы Действия И Нейропротективный Потенциал

Кутяков¹,

Шадрина²,

Труфанова³

et al. 2019

Эксп. и клин. фармакол.

View full text Add to dashboard Cite

Нестероидные противовоспалительные средства (НПВС) применяются для купирования болевого синдрома при многочисленных патологических состояниях — головной, зубной, мышечной боли, а также для лечения воспалительных процессов и в качестве жаропонижающих препаратов. Противовоспалительный и анальгезирующий эффекты взаимосвязаны, при этом противовоспалительный эффект доминирует. Основным механизмом действия НПВС является ингибирование биосинтеза простагландинов (ПГ), участвующих в развитии воспаления и болевого синдрома. Влиянием на синтез ПГ обусловлен основной побочный эффект НПВС — ульцерогенное действие. В настоящее время поиск новых НПВС направлен на минимизацию нежелательных реакций при сохранении всех основных фармакологических эффектов. Целью обзора являлись: 1) оценка и анализ перечня применяющихся в РФ НПВС, механизм действия, показания к их применению, возможные нежелательные эффекты, молекулярные, клеточные и функциональные мишени действия НПВС, возможности и перспективы поиска новых безопасных средств, обладающих противовоспалительной активностью; 2) характеристика особенности реализации эффектов ПНВС в центральной нервной системе.

show abstract

Role of Cyclooxygenase Inhibitors in Diminution of Dissimilar Stress-induced Depressive Behavior and Memory Impairment in Rats

Cited by 9 publications

References 53 publications

Behavioral and Biochemical Effects of Mukia madrespatana Following Single Immobilization Stress on Rats

Behavioral and Biochemical Effects of Mukia madrespatana Following Single Immobilization Stress on Rats

Antidepressant Effects of NSAIDs in Rodent Models of Depression—A Systematic Review

Нестероидные Противовоспалительные Средства: Ключевые Механизмы Действия И Нейропротективный Потенциал

Contact Info

Product

Resources

About