Role of current and childhood exposure to cat and atopic sensitization☆☆☆★

Roost, Hans-Peter; Künzli, Nino; Schindler, Christian; Jarvis, Déborah; Chinn, Susan; Perruchoud, André P.; Ackermann‐Liebrich, Ursula; Burney, Peter; Wüthrich, B

doi:10.1016/s0091-6749(99)70072-2

Cited by 218 publications

(180 citation statements)

References 46 publications

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“…Furthermore, three interchain disulfide bonds linking the two peptides in native Fel d 1 have been identified, i.e. Cys 3 (1)-Cys 73 (2), Cys 44 (1)-Cys 48 (2), and Cys 70 (1)-Cys 7 (2) (22), suggesting an anti-parallel orientation of Fel d 1 peptides. Several attempts have been made to associate the separate peptides into a native-like allergen in Escherichia coli with only partial success (31)(32)(33), and recently a soluble and immunoreactive chain 1-linker-chain 2 fusion expressed in baculovirus was described (34).…”

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confidence: 99%

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Formation of Disulfide Bonds and Homodimers of the Major Cat Allergen Fel d 1 Equivalent to the Natural Allergen by Expression in Escherichia coli

Grönlund

Bergman

Sandström

et al. 2003

Journal of Biological Chemistry

102

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confidence: 99%

“…Exposure to airborne particles derived from household cats (Felis domesticus) is a common cause of IgE-mediated allergy in Europe and elsewhere (1)(2)(3). The severity of symptoms range from relatively mild rhinitis and conjunctivitis to potentially life-threatening asthmatic exacerbation.…”

mentioning

confidence: 99%

Formation of Disulfide Bonds and Homodimers of the Major Cat Allergen Fel d 1 Equivalent to the Natural Allergen by Expression in Escherichia coli

Grönlund

Bergman

Sandström

et al. 2003

Journal of Biological Chemistry

102

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“…Similarly, the presence of a dog in the home during childhood is negatively associated with adult atopy [16]. Moreover, ROOST et al [17] pointed out that early child exposure to pets might modulate immunology mechanisms and reduce sensitization to cats in adulthood.…”

Section: Discussionmentioning

confidence: 99%

Cat sensitivity: 7-yr audit in children attending a paediatric allergy clinic in North Italy

Pescollderungg¹,

Pietrobelli²,

Boner³

2000

European Respiratory Journal

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Sensitivity to cats and exposure to cat allergen is a common cause of asthma exacerbation in children. To date, there is no data on the prevalence of cat sensitivity in children living in North Italy. Therefore, a 7-yr survey was performed in patients attending an allergy clinic for the first time.Skin prick tests (SPT) for perennial allergens and for pollens relevant to the region were performed in 4,957 children attending the outpatient clinic 1992±1998. A questionnaire on present or past cat ownership was presented to all cat-skin prick test positive children. An evaluation of cat ownership on the general population was made by telephone interview on a random sample of 1,268 families living in the same area.With a 3-mm wheal as a positive cut-off 439 (8.85%) children had a positive SPT to cats. Of these 103 (23.4%) had a cat at home and 336 (76.6%) never had a cat in the house. With a greater positive cut-off (a wheal diameter $4 mm) 140 (2.8%) showed a positive SPT to cats of these 35 (25%) had a cat at home and 105 (75%) had only an indirect exposure to the pet. Of the telephone interviewed families; 16% stated they had a cat at home.Cat sensitivity is less prevalent in Italy, in this hospital based population, compared with other European countries and this is in agreement with a lower rate of cat ownership. Cat sensitivity was three times more frequent in children who never had a cat at home, than in children living with cats, when the selected positive cut-off was either a wheal diameter of 3 mm or $4 mm. Thus in a population with a low prevalence of cat ownership public exposure seems to be more important than domestic exposure for the development of sensitivity. Eur Respir J 2000; 16: 857±860. Allergy to indoor allergens (house dust mites, domestic pets and cockroaches) is a major cause of ill health in children. In the USA, cat and dog allergens sensitivity has been shown to occur in up to 67% of asthmatic children in settings where they are the dominant indoor allergens [1,2]. In the UK, pet ownership is very common and approximately one-third of homes have a cat and one-quarter a dog [3]. Pets are the second most important cause of allergy in the domestic environment in the UK, and up to 40% of asthmatic children are sensitized to cat and/or dog allergens [4]. In a population survey in Northern Sweden cat and dog allergens elicited the greatest number of positive skin test responses; the proportion of children sensitized against cats was 13.4% and dogs 8.7% [5]. Furthermore, sensitization to cat allergen is common among asthmatic children in Japan where cat-specific immunoglobulin E (IgE) were found in sera of 70% of asthmatic children who kept cats and 34% of patients who had never kept cats at home [6]. In the German Multicenter Atopy Study cumulative rates of sensitization to cat antigen dI (Fel dI) among children with a family history of atopy were 5±6% in the first 3 yrs of life [7].Since no data on the prevalence of cat sensitivity in children is available from North Italy, the preva...

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“…Estudos populacionais recentes sugerem que a presença de gato na casa poderia reduzir o risco de sensibilização e asma 4,5 . Platts-Mills et al 6 investigaram a resposta imunológica aos alérgenos de gato e ácaro, em crianças com asma, pela determinação de anticorpos IgE, IgG e IgG 4 a Der f1…”

Section: Risk or Protective Factors?unclassified

“…Reconhecendo as limitações dos índices utilizados até agora e impulsionados pela necessidade crescente de informações cada vez mais rigorosas, têm surgido, nos últimos 4 , é um escore para recém-nascidos inspirado no APACHE, tem a vantagem de considerar e pontuar valores para reserva fisiológica, assim como permitir sua utilização em todos os recém-nascidos, independentemente…”

Section: Prognostic Indicators In Neonatologyunclassified

Fatores de risco ou de proteção?

Filho¹

2001

J. Pediatr. (Rio J.)

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Role of current and childhood exposure to cat and atopic sensitization☆☆☆★

Cited by 218 publications

References 46 publications

Formation of Disulfide Bonds and Homodimers of the Major Cat Allergen Fel d 1 Equivalent to the Natural Allergen by Expression in Escherichia coli

Formation of Disulfide Bonds and Homodimers of the Major Cat Allergen Fel d 1 Equivalent to the Natural Allergen by Expression in Escherichia coli

Cat sensitivity: 7-yr audit in children attending a paediatric allergy clinic in North Italy

Fatores de risco ou de proteção?

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