Role of complexes formation between drugs and penetration enhancers in transdermal delivery

Synthesis, in silico Study and Antimicrobial Evaluation of New Selenoglycolicamides

“…This study showed that the obtained results were not consistent with the Zloh and co-workers 40,41 affirmation, i.e., this rule does not apply to glycolic amides. The compounds 7g, 7c and 7e showed the highest lipophilicity values, and they should demonstrate antimicrobial action results consistent with the Zloh co-workers 40,41 affirmation; however, they were not the most active strains tested. The compounds with halogens in their structure can increase lipophilicity, as was shown by the compounds 7f and 7i, both with chlorine, which presented better results against the strains IS-58 (TetK), RN-4220 (MsrA) and SA-1199B (NorA).…”

“…According to Zloh and co-workers, 40,41 a characteristic of substances that possess a high degree of lipophilicity is the ability to inhibit the multidrug-resistant bacteria (MRB) that have efflux proteins as a defense mechanism. This study showed that the obtained results were not consistent with the Zloh and co-workers 40,41 affirmation, i.e., this rule does not apply to glycolic amides.…”

Physicochemical investigation and molecular modeling of cyclodextrin complexation mechanism with eugenol

“…Due to the limitations of the experimental methods especially in food and pharmaceutical research, in silico modeling has been used as powerful tools for deriving information and rationalizing experimental findings on the geometry and the interaction energy of the molecular complex formation (Drakulić , Juranić , Erić , & Zloh, 2008;Filippa, Sancho, & Gasull, 2008;Francoa et al, 2009). Moreover, thermodynamic information, stoichiometry and association constant are necessary to draw a complete picture of the driving forces governing the interaction, which would be useful for the prediction of the formulations and product development.…”

Transcriptional Regulation of Fibroblast Growth Factor 21 Expression

“…Activation of PPARγ also increases the secretion of adipokines implicated in whole-body insulin sensitization [33]. Recent studies demonstrated that PPARγ activation increases FGF21 production in adipose tissue, the secondary source of FGF21, which then acts as an autocrine or endocrine factor to improve insulin action [21,34]. …”