Role of Click Chemistry in Organic Synthesis

Abstract

Click chemistry involves highly efficient organic reactions of two or more highly functionalized chemical entities under eco-benign conditions for the synthesis of different heterocycles. Several organic reactions such as nucleophilic ring-opening reactions, cyclo-additions, nucleophilic addition reactions, thiol-ene reactions, Diels Alder reactions, etc. are included in click reactions. These reactions have very important features i.e. high functional group tolerance, formation of a single product, high atom economy, high yielding, no need for column purification, etc. It also possesses several applications in drug discovery, supramolecular chemistry, material science, nanotechnology, etc. Being highly significant and valuable, we have elaborated on several aspects of click reactions in organic synthesis in this chapter. Recent advancements in the field of organic synthesis using click chemistry approach have been deliberated by citing last five years articles.

A New Insight Into The Huisgen Reaction: Heterogeneous Copper Catalyzed Azide‐Alkyne Cycloaddition for the Synthesis of 1,4‐Disubstituted Triazole (From 2018–2023)

“…The exploration of click reactions extensively includes the synthesis of substituted 1,2,3‐triazoles by employing the Huisgen 1,3‐dipolar cycloaddition, which involves the reaction between azide derivatives and terminal alkynes [32,33] . The synthesis of triazoles has various benefits in the field of “click chemistry,” including effective atom economy, high yields, great selectivity, the use of water as a solvent, and gentle reaction conditions [34–36] . Traditionally, copper catalysts have made the cycloaddition of azides and terminal alkynes to produce 1,4‐disubstituted 1,2,3‐triazoles easier [26] .…”

Synthesis and biological activity profile of novel triazole/quinoline hybrids

“…Click reactions are a useful strategy for the synthesis of heterocyclic compounds that produce desirable products in a wide range, in addition to separable by‐products (Meldal & Diness, 2020). Click reactions are categorized into four major classes (Sethiya et al, 2021): nucleophilic substitution, nucleophilic addition, addition to C‐C multiple bonds, and cycloaddition. The last reaction includes 1,3‐dipolar cycloaddition (Huisgen cycloaddition) and hetero‐Diels‐Alder cycloaddition.…”

Synthesis and characterization of poly(ε-caprolactone) tetra-arm star polymer using tetra terminal alkynyl-substituted phthalocyanine by the combination of ring-opening polymerization and “click” chemistry

“…Recently, "click" technics have appeared in the synthesis of new structured macromolecules, which enable them to take place in many fields of science [23][24][25]. The principal characteristics of "click" chemistry are shown by simple reaction conditions, high tolerances of functional groups, lack of byproducts, light, and simple product isolations [26][27][28].…”