Role of central serotonin and noradrenaline interactions in the antidepressants’ action: Electrophysiological and neurochemical evidence

Delcourte, Sarah; Etiévant, Adeline; Haddjeri, Nasser

doi:10.1016/bs.pbr.2021.01.002

Cited by 5 publications

(2 citation statements)

References 556 publications

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“…In particular, c-oryzanol treatment prevented the reduction of serotonin and octopamine in the depressed Drosophila model induced by UCMS. In addition, the development of antidepressants is related to theories based on serotonin deficiency, and numerous evidence suggests that various classes of antidepressant may induce enhancement of serotonin neurotransmission (Cowen and Browning 2015;Delcourte et al 2021). Collectively, the results suggest that HE administration significantly ameliorates dopamine and serotonin levels.…”

Section: Discussionmentioning

confidence: 90%

Anti-depressant effects of ethanol extract from Cannabis sativa (hemp) seed in chlorpromazine-induced Drosophila melanogaster depression model

Kim

Han

Kim

et al. 2021

Pharmaceutical Biology

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Context: Depression is a severe mental illness caused by a deficiency of dopamine and serotonin. Cannabis sativa L. (Cannabaceae) has long been used to treat pain, nausea, and depression.Objective: This study investigates the anti-depressant effects of C. sativa (hemp) seed ethanol extract (HE) in chlorpromazine (CPZ)-induced Drosophila melanogaster depression model. Materials and methods: The normal group was untreated, and the control group was treated with CPZ (0.1% of media) for 7 days. The experimental groups were treated with a single HE treatment (0.5, 1.0, and 1.5% of media) and a mixture of 0.1% CPZ and HE for 7 days. The locomotor activity, behavioural patterns, depression-related gene expression, and neurotransmitters level of flies were investigated. Results: The behavioural patterns of individual flies were significantly reduced with 0.1% CPZ treatment. In contrast, combination treatment of 1.5% HE and 0.1% CPZ significantly increased subjective daytime activity (p < 0.001) and behavioural factors (p < 0.001). These results correlate with increased transcript levels of dopamine (p < 0.001) and serotonin (p < 0.05) receptors and concentration of dopamine (p < 0.05), levodopa (p < 0.001), 5-HTP (p < 0.05), and serotonin (p < 0.001) compared to those in the control group. Discussion and conclusions: Collectively, HE administration alleviates depression-like symptoms by modulating the circadian rhythm-related behaviours, transcript levels of neurotransmitter receptors, and neurotransmitter levels in the CPZ-induced Drosophila model. However, additional research is needed to investigate the role of HE administration in behavioural patterns, reduction of the neurotransmitter, and signalling pathways of depression in a vertebrate model system.

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Section: Discussionmentioning

confidence: 90%

Anti-depressant effects of ethanol extract from Cannabis sativa (hemp) seed in chlorpromazine-induced Drosophila melanogaster depression model

Kim

Han

Kim

et al. 2021

Pharmaceutical Biology

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“…More recently, one study suggests that this punishment-evoked dissociation DRN 5HT is circuit-dependent, in which the central amygdala-projecting neurons were activated, whereas the orbitofrontal cortex-projecting neurons were inhibited, toward foot shock (Ren et al, 2018). Together, these discrepancies could be due to the complicated interactions of other neuromodulators (e.g., GABA and glutamate) and heterogeneous 5HT sub-receptor pathways are involved (Szabo & Blier, 2001; Masse et al, 2006; Ortega et al, 2012; Fernandez-Pastor et al, 2013; Liu et al, 2014; Delcourte et al, 2021), therefore future studies with more synaptic-specific approaches are required to fully explain the 5HT mechanisms underpinning behavior and cognition.…”

Section: Discussionmentioning

confidence: 99%

Frontal cortex norepinephrine, serotonin, and dopamine dynamics in an innate fear-reward behavioral model

Yang,

Basu,

Liu

et al. 2023

Preprint

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Animals must survive by foraging for food in an uncertain and dangerous world. Experimental tasks such as Pavlovian learning have yielded insights into how neural circuits balance these conflicting motivational drives. Neuromodulators play a fundamental role in this process, enabling flexible switching between motivational drives. The question of how neuromodulators synergistically encode motivational state is thus fundamental to systems neuroscience, yet the interplay between these neuromodulators during naturalistic decision making are not fully understood. Here, we developed a naturalistic approach/avoidance task in mice involving a tradeoff between seeking reward versus safety in the presence of looming predation risk. We utilized multi-fiber photometry, computational behavior tracking, and slice electrophysiology to understand the. Mice that experienced looming stimuli showed increased c-fos expression in regions including frontal cortex, locus coeruleus, and ventral tegmental area, but decreased expression in dorsal raphe nucleus. Moreover, by using multi-fiber photometry combined with GPCR-based sensors, we found that cortical norepinephrine (NE) plays a more prominent role in encoding looming threats while dopamine (DA) represents reward and threat. In contrast, serotonin (5HT) dynamic negatively correlates to both emotional valences. To begin to understand neuromodulatory interactions, we usedex vivoslice physiology to understand 5HT impact on spontaneous firing of locus coeruleus NE neurons. In conclusion, monoamines such as NE, DA, 5HT can converge in their encoding of naturalistic motivated behaviors as well as dissociate from one another. By utilizing this approach, interactions between innate fear and incentive for food may be delineated in terms of basis in neurochemical signaling events during natural behavior, and may contribute to the understanding of neural mechanisms underlying emotional disorders including anxiety and post-traumatic stress disorder.

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Involvement of serotonergic neurotransmission in the antidepressant-like effect elicited by cholecalciferol in the chronic unpredictable stress model in mice

et al. 2022

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Role of central serotonin and noradrenaline interactions in the antidepressants’ action: Electrophysiological and neurochemical evidence

Cited by 5 publications

References 556 publications

Anti-depressant effects of ethanol extract from Cannabis sativa (hemp) seed in chlorpromazine-induced Drosophila melanogaster depression model

Anti-depressant effects of ethanol extract from Cannabis sativa (hemp) seed in chlorpromazine-induced Drosophila melanogaster depression model

Frontal cortex norepinephrine, serotonin, and dopamine dynamics in an innate fear-reward behavioral model

Involvement of serotonergic neurotransmission in the antidepressant-like effect elicited by cholecalciferol in the chronic unpredictable stress model in mice

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