Role of central 5-HT3 receptors in the control of blood pressure in stressed and non-stressed rats

Ferreira, Hadla S.; Silva, Emilio de Castro e; Cointeiro, Carla; Oliveira, Elenilda Farias de; Faustino, Thiallan Nery; Fregoneze, J.B.

doi:10.1016/j.brainres.2004.08.063

Cited by 14 publications

(8 citation statements)

References 36 publications

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“…Two lines of evidence suggest that it was not in the CNS: firstly, central administration of ondasetron caused opposite effect (rise in the AP) in conscious rats (Ferreira et al, 2004). Secondly, both tertiary form of tropisetron (blood-brain barrier-permeant) and its nonpermeant quaternary form were equipotent in reducing AP in the spontaneously hypertensive rats (Alkadhi et al, 2001).…”

Section: Stress-induced Long-term Potentiation In Sympathetic Gangliamentioning

confidence: 98%

Central 5-HT receptors in cardiovascular control during stress

Nalivaiko

Sgoifo

2009

Neuroscience & Biobehavioral Reviews

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Section: Stress-induced Long-term Potentiation In Sympathetic Gangliamentioning

confidence: 98%

Central 5-HT receptors in cardiovascular control during stress

Nalivaiko

Sgoifo

2009

Neuroscience & Biobehavioral Reviews

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“…We have previously demonstrated that central brain 5-HT 3 receptors exert tonic depressor effects on blood pressure in nonstressed rats, probably through a sympathoinhibitory-related mechanism (Ferreira et al, 2004). The effect of the 5-HT 3 agents on blood pressure control shown in that study may be partially explained by their action on the septal area, since when the same serotonergic agents were administered in the medial septum/ vertical limb of the diagonal band complex (MS/vDB), 5-HT 3 receptors located in this area were also shown to exert a tonic sympathoinhibitory effect that seems to be mediated by an angiotensinergic-dependent mechanism (Urzedo-Rodrigues et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Multiple opioid receptors mediate the hypotensive response induced by central 5-HT3 receptor stimulation

et al. 2011

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The aim of the present work was to investigate the role of brain μ, κ and δ opioid receptors in the central serotonergic mechanisms regulating blood pressure in rats. The data obtained show that: (1) pharmacological activation of central 5-HT(3) receptors yields a significant decrease in blood pressure; (2) the blockade of those receptors by a selective antagonist induces an acute hypertensive response; (3) the pharmacological blockade of central opioid receptors by three different opioid antagonists exhibiting variable degrees of selectivity to μ, κ and δ opioid receptors always suppressed the hypotensive response induced by central 5-HT(3) receptor stimulation; (4) the blockade of opioid receptors by the same opioid antagonists that impaired the hypotensive effect of central 5-HT(3) receptor stimulation failed to modify blood pressure in animals not submitted to pharmacological manipulations of central 5-HT(3) receptor function. It is shown that a 5-HT(3) receptor-dependent mechanism seems to be part of the brain serotonergic system that contributes to cardiovascular regulation since the hypertensive response observed after ondansetron administration indicates that central 5-HT(3) receptors exert a tonic inhibitory drive on blood pressure. Furthermore, the data obtained here clearly indicate that the hypotensive response observed after pharmacological stimulation of central 5-HT(3) receptors depends on the functional integrity of brain μ, κ and δ opioid receptors, suggesting that a functional interaction between serotonergic and opiatergic pathways in the brain is part of the complex, multifactorial system that regulates blood pressure in the central nervous system.

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“…Also, SCOC (short coiled-coil protein) has been significantly associated with hypertension [78]. HTR3B was previously identified as having a possible link to the control of blood pressure in rats, through its central influence on the sympathoinhibitory mechanism [74,79]. While this study focused on rats, it provides enough evidence to warrant HTR3B as being a candidate for examination in human-based GWAS studies.…”

Section: Resultsmentioning

confidence: 96%

Wrapper-based selection of genetic features in genome-wide association studies through fast matrix operations

Pahikkala

Okser

Airola

et al. 2012

Algorithms Mol Biol

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BackgroundThrough the wealth of information contained within them, genome-wide association studies (GWAS) have the potential to provide researchers with a systematic means of associating genetic variants with a wide variety of disease phenotypes. Due to the limitations of approaches that have analyzed single variants one at a time, it has been proposed that the genetic basis of these disorders could be determined through detailed analysis of the genetic variants themselves and in conjunction with one another. The construction of models that account for these subsets of variants requires methodologies that generate predictions based on the total risk of a particular group of polymorphisms. However, due to the excessive number of variants, constructing these types of models has so far been computationally infeasible.ResultsWe have implemented an algorithm, known as greedy RLS, that we use to perform the first known wrapper-based feature selection on the genome-wide level. The running time of greedy RLS grows linearly in the number of training examples, the number of features in the original data set, and the number of selected features. This speed is achieved through computational short-cuts based on matrix calculus. Since the memory consumption in present-day computers can form an even tighter bottleneck than running time, we also developed a space efficient variation of greedy RLS which trades running time for memory. These approaches are then compared to traditional wrapper-based feature selection implementations based on support vector machines (SVM) to reveal the relative speed-up and to assess the feasibility of the new algorithm. As a proof of concept, we apply greedy RLS to the Hypertension – UK National Blood Service WTCCC dataset and select the most predictive variants using 3-fold external cross-validation in less than 26 minutes on a high-end desktop. On this dataset, we also show that greedy RLS has a better classification performance on independent test data than a classifier trained using features selected by a statistical p-value-based filter, which is currently the most popular approach for constructing predictive models in GWAS.ConclusionsGreedy RLS is the first known implementation of a machine learning based method with the capability to conduct a wrapper-based feature selection on an entire GWAS containing several thousand examples and over 400,000 variants. In our experiments, greedy RLS selected a highly predictive subset of genetic variants in a fraction of the time spent by wrapper-based selection methods used together with SVM classifiers. The proposed algorithms are freely available as part of the RLScore software library at http://users.utu.fi/aatapa/RLScore/.

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Role of central 5-HT3 receptors in the control of blood pressure in stressed and non-stressed rats

Cited by 14 publications

References 36 publications

Central 5-HT receptors in cardiovascular control during stress

Central 5-HT receptors in cardiovascular control during stress

Multiple opioid receptors mediate the hypotensive response induced by central 5-HT3 receptor stimulation

Wrapper-based selection of genetic features in genome-wide association studies through fast matrix operations

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