Role of autophagy in follicular development and maintenance of primordial follicular pool in the ovary

Bhardwaj, Jitender Kumar; Paliwal, Aakansha; Saraf, Priyanka; Sachdeva, S. N.

doi:10.1002/jcp.30613

Cited by 57 publications

(34 citation statements)

References 84 publications

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“…PI3K/AKT/mTOR signaling pathway is a pivotal regulator of autophagy 114 , 115 . Li et al 116 revealed that BMMSC-exo could ameliorate the inflammation and apoptosis of AFc by inhibiting the expression of PI3K/AKT/mTOR signaling pathway.…”

Section: Exosome Derived From Stem Cellsmentioning

confidence: 99%

Insights into Exosome in the Intervertebral Disc: Emerging Role for Disc Homeostasis and Normal Function

Zhao¹,

Xu²,

Duan³

et al. 2022

Int. J. Med. Sci.

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Low back pain (LBP) is a chronic condition that causes great individual suffering and economic burden. The major contributor of LBP is intervertebral disc degeneration (IDD), which is caused by a spectrum of homeostasis alteration, including the apoptosis of nucleus pulposus (NP) and annulus fibrosus (AF) cells, degradation of extracellular matrix (ECM), calcification of cartilaginous endplates (CEP) and so on. Currently, the therapeutic strategy for IDD includes conservative and surgery treatment. Nevertheless, none of them could reverse the progressive destruction of the intervertebral disc. Hence, it is pivotal to pursue a new therapeutic approach. Exosomes, nano-sized substances with diameters of 30-150 nm, can be synthesized and secreted by various types of cells. They play an important role in intercellular communication. Increasing evidence implicates that exosomes could impact the intracellular transcription activities, thereby inhibiting or accelerating the proliferation and apoptosis of cells. Thus, it is a new therapeutic source for IDD. This review chiefly focuses on generalizing and clarifying the roles of exosomes in the onset and deterioration of IDD, and their therapeutic potential.

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Section: Exosome Derived From Stem Cellsmentioning

confidence: 99%

Insights into Exosome in the Intervertebral Disc: Emerging Role for Disc Homeostasis and Normal Function

Zhao¹,

Xu²,

Duan³

et al. 2022

Int. J. Med. Sci.

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“…However, increasing evidence suggests that apoptosis is not the exclusive mechanism and that autophagy represents an alternative non-apoptotic process that contributes to the efficient elimination of granulosa cells and oocytes (Cassel et al, 2017;Corriero et al, 2021;Morais et al, 2012Morais et al, , 2016Sales et al, 2019;Santos et al, 2008;Thomé et al, 2009). Recently, a review paper by Bhardwaj et al (2022) has reported the implication of autophagy marker genes also in the process of atresia in mammals and involving all cell types forming the follicle. Autophagy recycles nutrients from degraded cell organelles in the follicle, and hence could provide the energy that may be required for future oocyte and egg production in vertebrates (Bhardwaj et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…Recently, a review paper by Bhardwaj et al (2022) has reported the implication of autophagy marker genes also in the process of atresia in mammals and involving all cell types forming the follicle. Autophagy recycles nutrients from degraded cell organelles in the follicle, and hence could provide the energy that may be required for future oocyte and egg production in vertebrates (Bhardwaj et al, 2022). Whereas in mammals, apoptosis in cells that form the ovarian follicles is considered the main cellular mechanism mediating early ovarian atresia (Hsueh et al, 1994;Matsuda et al, 2012;Tilly, 1996aTilly, , 1996bTiwari et al, 2015), in fish, apoptosis is accompanied by autophagy at least during the late stages of follicular atresia (Miranda et al, 1999;Morais et al, 2012); thus suggesting the existence of another novel pathway during follicular atresia (Yang et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Apoptosis and autophagy-related gene transcription during ovarian follicular atresia in European hake (Merluccius merluccius)

Nzioka

Valencia

Atxaerandio-Landa

et al. 2023

Marine Environmental Research

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“…After birth, with the animal growth and development, the majority of follicles undergo atresia and degeneration ( 3 ). Post-puberty only a few follicles develop to mature, but the absolute number of follicles decreases with age ( 4 ). If female animal has ovarian disease, the limited resources cannot be used effectively, which causes significant losses to the breeding industry.…”

Section: Introductionmentioning

confidence: 99%

Analyzing the interactions of mRNAs, miRNAs and lncRNAs to predict ceRNA networks in bovine cystic follicular granulosa cells

et al. 2022

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Cross-talk between competitive endogenous RNAs (ceRNAs) may play a critical role in revealing potential mechanism of bovine follicular cysts. Ovarian cyst has always been an intractable scientific problem and has led to considerable economic losses to bovine breeding industry. However, its pathogenesis and molecular mechanisms are still not well understood. Here, this study aimed to investigate the role of non-coding RNAs (ncRNAs) and the ceRNA networks in bovine follicular cyst. Whole transcriptome sequencing of bovine follicular granulosa cells (GCs) was conducted to obtain the expression profiles of mRNAs, lncRNAs and miRNAs. The results for the identified expressions of 8,003 mRNAs, 579 lncRNAs and 205 miRNAs were often altered between cystic and normal follicular GCs. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were performed on these differentially expressed mRNAs. Furthermore, the ceRNA network combining mRNAs, miRNAs, and lncRNAs using several bioinformatics methods based on co-expression analysis between the differentially expressed RNAs was conducted. Finally, the lncRNA NONBTAT027373.1-miR-664b-HSD17B7 pathway was verified by dual-luciferase reporting assay and RNA binding protein immunoprecipitation (RIP) assay. LncRNA NONBTAT027373.1 sponged miR-664b in GCs and prevented miR-664b from binding to the HSD17B7 3′-UTR. These results indicated that genes and lncRNAs related to steroid hormone synthesis and energy metabolism could play important roles in the formation of bovine cystic follicles through the ceRNA mechanism and represent candidate targets for further research. This can be used as a practical guideline for promoting healthy and highly efficient development in the bovine industry.

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Role of autophagy in follicular development and maintenance of primordial follicular pool in the ovary

Cited by 57 publications

References 84 publications

Insights into Exosome in the Intervertebral Disc: Emerging Role for Disc Homeostasis and Normal Function

Insights into Exosome in the Intervertebral Disc: Emerging Role for Disc Homeostasis and Normal Function

Apoptosis and autophagy-related gene transcription during ovarian follicular atresia in European hake (Merluccius merluccius)

Analyzing the interactions of mRNAs, miRNAs and lncRNAs to predict ceRNA networks in bovine cystic follicular granulosa cells

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