Role of Aryl Hydrocarbon Receptor Activation in Inflammatory Chronic Skin Diseases

Napolitano, Maddalena; Fabbrocini, Gabriella; Picone, Vincenzo; Morelli, Paola; Patruno, Cataldo

doi:10.3390/cells10123559

Cited by 42 publications

(45 citation statements)

References 106 publications

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“…The above-mentioned treatments have a positive effect on the reduction of acne lesions, reduction of the level of sebum on the surface of the epidermis, and improvement of skin hydration [ 25 , 26 ]. We hope that our research results and the treatments that we have proposed, can be used by other researchers to apply them to another disease, for example hidradenitis suppurativa [ 27 , 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Hydrogen Purification and Cosmetic Acids in the Treatment of Acne Vulgaris: A Preliminary Report

Chilicka

Rusztowicz

Rogowska

et al. 2022

JCM

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Acne and skin lesions that appear in its course deteriorate the quality of life of patients, cause depression and the emergence of suicidal thoughts. Cosmetic treatments can have a positive effect on improving skin condition by cleaning up skin eruptions, thus improving the well-being of affected people. Hydrogen purification is a treatment that uses alkaline water generated by a device, which reduces sebum from the surface of the epidermis. This is a novel treatment that has recently been introduced to beauty salons. On the other hand, cosmetic acids have been used for many years for treating people with acne vulgaris and give spectacular results in terms of improving the skin condition. In this study, skin condition was evaluated with a Derma Unit SSC 3 device. The Global Acne Grading System (GAGS) was used to check acne severity. Twenty-four women aged 19–21 years (M = 20.13, SD = 0.80) diagnosed with mild acne vulgaris and a high sebum level participated in the study. Group A underwent a hydrogen purification treatment using an H2jet manipulator, which ejected alkaline water from the manipulator under pressure. Group B underwent a hydrogen purification treatment with the use of a phytic, pyruvic, lactic and ferulic acids at 40% mixture (pH 1.4). A series of four treatments was performed at 14-day intervals in both groups. Skin parameters were measured before and 30 days after the series of treatment. Very good results were obtained in both groups. The skin eruptions in patients were reduced and we also observed lower amounts of sebum on the surface of the epidermis, and an improvement in skin hydration. However, in group B, the results were better than in group A. The study showed that the synergy of the treatments produced much better effects than those obtained by completing the hydrogen purification treatment alone.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Hydrogen Purification and Cosmetic Acids in the Treatment of Acne Vulgaris: A Preliminary Report

Chilicka

Rusztowicz

Rogowska

et al. 2022

JCM

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“…Therefore, targeting the AHR-AurA and, more broadly, the AHR-polo-like kinase axis, provides an exciting new avenue for treating hematologic diseases. Given that AHR also affects proliferation of other cell types, it is possible that AHR-AurA connections contribute to AHR's role regulating proliferation of nonhematopoietic cells in peripheral tissues, including the mammary gland, skin, and nervous systems [63][64][65]. Moreover, these new findings point to a broader role of AHR in other types of progenitor cells, such as those in the skin, liver and GI tract, which have high levels of AHR, are sensitive to modulation by AHR ligands, and in which AHR signaling has been associated with altered proliferation [59,[66][67][68].…”

Section: Discussionmentioning

confidence: 99%

Impact of the aryl hydrocarbon receptor on Aurora A kinase and the G2/M phase pathway in hematopoietic stem and progenitor cells

Franchini

Vaughan

Bhattacharya

et al. 2022

Preprint

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Recent evidence suggests that the environment-sensing transcription factor aryl hydrocarbon receptor (AHR) is an important regulator of hematopoiesis. Yet, the mechanisms and extent of AHR-mediated regulation within the most primitive hematopoietic cells, hematopoietic stem and progenitor cells (HSPCs), are poorly understood. Through a combination of transcriptomic and flow cytometric approaches, this study provides new insight into how the AHR influences HSPCs. Comparative analysis of intraphenotypic transcriptomes of hematopoietic stem cells (HSCs) and multipotent progenitor (MPP) cells from AHR knockout (AHR KO) and wild-type (WT) mice revealed significant differences in gene expression patterns. Notable among these were differences in expression of cell cycle regulators, specifically an enrichment of G2/M checkpoint genes when Ahr was absent. This included the regulator Aurora A kinase (Aurka, AurA). Interrogation of AurA protein levels in HSPC subsets using flow cytometry, in combination with inducible AHR KO or in vivo AHR antagonism showed that attenuation of AHR increased levels of AurA in HSCs and lineage-biased MPP cells. Overall, these data highlight a potential novel mechanism by which AHR controls HSC homeostasis and HSPC differentiation. These findings advance the understanding of how AHR influences and regulates primitive hematopoiesis.

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“…The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that is highly expressed in keratinocytes [ 77 ]. It can be activated by a variety of ligands and regulates processes that maintain skin homeostasis including keratinocyte differentiation, skin barrier function, and responses to oxidative stress [ 77 , 78 ].…”

Section: Pipeline Therapiesmentioning

confidence: 99%

A Review of the Clinical Trial Landscape in Psoriasis: An Update for Clinicians

Drakos

Vender

2022

Dermatol Ther (Heidelb)

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As our understanding of the pathogenesis of psoriasis has evolved over the past two decades, so has the number of treatment options. The introduction of biologic agents targeting specific cytokines in the interleukin (IL)-23/IL-17 pathway has proven successful in promoting skin clearance among patients. However, their use is often limited owing to cost, parenteral administration, and possible reduced efficacy over time. Topical therapies have also seen limited advancement, with agents such as corticosteroids and vitamin D derivatives remaining the mainstay of treatment, despite side effects limiting their long-term use. New therapeutic agents are needed to improve disease management for patients. In this review, we summarize pipeline and recently approved therapies undergoing clinical trials for psoriasis during a 12-month search period (30 June 2021 to 30 June 2022) using ClinicalTrials.gov. New-generation biologics and oral small molecules in phase II or III development were included, and pivotal data identified through various search modalities (PubMed, conference presentations, etc.) evaluating each drug candidate will be discussed. Topical therapies will also be discussed in line with recent US Food and Drug Administration approvals. As new therapies continue to enter the treatment landscape, long-term data and comparative trials will be needed to better understand their place among existing therapeutic agents.

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Role of Aryl Hydrocarbon Receptor Activation in Inflammatory Chronic Skin Diseases

Cited by 42 publications

References 106 publications

Efficacy of Hydrogen Purification and Cosmetic Acids in the Treatment of Acne Vulgaris: A Preliminary Report

Efficacy of Hydrogen Purification and Cosmetic Acids in the Treatment of Acne Vulgaris: A Preliminary Report

Impact of the aryl hydrocarbon receptor on Aurora A kinase and the G2/M phase pathway in hematopoietic stem and progenitor cells

A Review of the Clinical Trial Landscape in Psoriasis: An Update for Clinicians

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