Role of Antiribosomal P Protein Antibodies in the Diagnosis of Lupus Isolated to the Central Nervous System

Abstract

Antiribosomal P protein antibodies provide an important confirmatory test for the diagnosis of lupus isolated to the central nervous system when results of tests for anti-double-stranded DNA antibodies are negative.

Immunoserological changes in the cerebro-spinal fluid and serum in systemic lupus erythematosus patients with demyelinating syndrome and multiple sclerosis

“…In 12–16% of the SLE patients the presence of antiribosomal P protein antibodies was demonstrated. The appearance of this type of antibody was observed more often in patients with psychiatric symptoms (4, 25). Antiribosomal P protein antibodies were presented in patients with focal neurological symptoms.…”

Immunoserological changes in the cerebro-spinal fluid and serum in systemic lupus erythematosus patients with demyelinating syndrome and multiple sclerosis

“…In 12–16% of the SLE patients the presence of antiribosomal P protein antibodies was demonstrated. The appearance of this type of antibody was observed more often in patients with psychiatric symptoms (4, 25). Antiribosomal P protein antibodies were presented in patients with focal neurological symptoms.…”

A 17-Year-Old Female with Systemic Lupus Presents with Complex Movement Disorder: Possible Relationship with Antiribosomal P Antibodies

“…Lupus anticoagulants were also positive in our patient but in our literature review we did not come across any data regarding a relation between lupus anticoagulant and the neuronal membrane. Agius et al published a case that initially presented with acute psychosis accompanied by chronic movements and of all the lab parameters only ribosomal P antibodies were positive [24]. Moreover in a study by Aldar et al on 50 pediatric SLE patients, antiribosomal P antibodies were positive in 13 patients and only one of these patients had chorea [25].…”

Overlap collagen vascular disease as a marker for development of primary biliary cirrhosis

“…Although historically our patient first developed a disease more consistent with SSc, at the time of presentation the patient had clinical as well as serologic features of overlap SSc/SLE and anti‐P‐As. The clinical relevance of anti‐P‐As in SLE is controversial; however, there is an association with CNS disease, and 45–90% of the patients with SLE and anti‐P‐As have a psychosis or major depression 5,6 , 9,11 , 15 . To date such an association has not been studied in the few patients with SSc/SLE overlap and anti‐P‐As 1 …”

Immunoserological changes in the cerebro-spinal fluid and serum in systemic lupus erythematosus patients with demyelinating syndrome and multiple sclerosis

“…In 12–16% of the SLE patients the presence of antiribosomal P protein antibodies was demonstrated. The appearance of this type of antibody was observed more often in patients with psychiatric symptoms (4, 25). Antiribosomal P protein antibodies were presented in patients with focal neurological symptoms.…”

A 17-Year-Old Female with Systemic Lupus Presents with Complex Movement Disorder: Possible Relationship with Antiribosomal P Antibodies

“…Lupus anticoagulants were also positive in our patient but in our literature review we did not come across any data regarding a relation between lupus anticoagulant and the neuronal membrane. Agius et al published a case that initially presented with acute psychosis accompanied by chronic movements and of all the lab parameters only ribosomal P antibodies were positive [24]. Moreover in a study by Aldar et al on 50 pediatric SLE patients, antiribosomal P antibodies were positive in 13 patients and only one of these patients had chorea [25].…”

Overlap collagen vascular disease as a marker for development of primary biliary cirrhosis

“…Although historically our patient first developed a disease more consistent with SSc, at the time of presentation the patient had clinical as well as serologic features of overlap SSc/SLE and anti‐P‐As. The clinical relevance of anti‐P‐As in SLE is controversial; however, there is an association with CNS disease, and 45–90% of the patients with SLE and anti‐P‐As have a psychosis or major depression 5,6 , 9,11 , 15 . To date such an association has not been studied in the few patients with SSc/SLE overlap and anti‐P‐As 1 …”

Immunoserological changes in the cerebro-spinal fluid and serum in systemic lupus erythematosus patients with demyelinating syndrome and multiple sclerosis

“…In 12–16% of the SLE patients the presence of antiribosomal P protein antibodies was demonstrated. The appearance of this type of antibody was observed more often in patients with psychiatric symptoms (4, 25). Antiribosomal P protein antibodies were presented in patients with focal neurological symptoms.…”

A 17-Year-Old Female with Systemic Lupus Presents with Complex Movement Disorder: Possible Relationship with Antiribosomal P Antibodies

“…Lupus anticoagulants were also positive in our patient but in our literature review we did not come across any data regarding a relation between lupus anticoagulant and the neuronal membrane. Agius et al published a case that initially presented with acute psychosis accompanied by chronic movements and of all the lab parameters only ribosomal P antibodies were positive [24]. Moreover in a study by Aldar et al on 50 pediatric SLE patients, antiribosomal P antibodies were positive in 13 patients and only one of these patients had chorea [25].…”

Overlap collagen vascular disease as a marker for development of primary biliary cirrhosis

“…Although historically our patient first developed a disease more consistent with SSc, at the time of presentation the patient had clinical as well as serologic features of overlap SSc/SLE and anti‐P‐As. The clinical relevance of anti‐P‐As in SLE is controversial; however, there is an association with CNS disease, and 45–90% of the patients with SLE and anti‐P‐As have a psychosis or major depression 5,6 , 9,11 , 15 . To date such an association has not been studied in the few patients with SSc/SLE overlap and anti‐P‐As 1 …”