Role of AMPK/SIRT1-SIRT3 signaling pathway in affective disorders in unpredictable chronic mild stress mice

Yu, Xuefeng; Hu, Ying; Huang, Weilai; Ye, Nuo; Yan, Qizhi; Ni, Wenjuan; Jiang, Xi

doi:10.1016/j.neuropharm.2019.107925

Cited by 19 publications

(17 citation statements)

References 51 publications

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“…The overproduction of ROS was detected in patients with depression ( Bilici et al, 2001 ). The study conducted by Yu X et al demonstrated that mice experienced chronic mild stress displayed deficiency in SIRT3 expression, as well as the overexpression of ROS, p-NF-κB p65 and IL-1β ( Yu et al, 2020 ). Additionally, AICA Riboside intervention which restored hippocampal SIRT3 expression significantly ameliorated the depression-like and anxiety-like behaviors of CUMS mice.…”

Section: Discussionmentioning

confidence: 99%

α-Cyperone Confers Antidepressant-Like Effects in Mice via Neuroplasticity Enhancement by SIRT3/ROS Mediated NLRP3 Inflammasome Deactivation

et al. 2020

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α-Cyperone (Cy) is a major active compound of Cyperus rotundus that has various pharmacological activities. But whether Cy possesses antidepressant effect is unknown. In this study, we exposed mice to chronic unpredictable mild stress (CUMS) with or without intervention with Cy. Our results showed that Cy significantly improved the depressive phenotypes in sucrose preference test, tail suspension test and forced swimming test. Meanwhile, increased SIRT3 expression, reduced ROS production and activated NF-κB signal were detected in the hippocampus of mice. NLRP3 inflammasome related proteins including NLRP3, ASC, Caspase-1, IL-1β, IL-18 and GSDMD-N were downregulated after Cy administration. Synaptic proteins including Synapsin-1 and PSD-95 and dendritic spine density were improved after Cy treatment. Moreover, the protective effects of Cy in CUMS mice were compromised when co-administrated with SIRT3 inhibitor 3-TYP. Taken together, these findings suggested that Cy has therapeutic potential for treating depression and that this antidepressant effect may be attributed to SIRT3 stimulated neuroplasticity enhancement by suppressing NLRP3 inflammasome.

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Section: Discussionmentioning

confidence: 99%

α-Cyperone Confers Antidepressant-Like Effects in Mice via Neuroplasticity Enhancement by SIRT3/ROS Mediated NLRP3 Inflammasome Deactivation

et al. 2020

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“…Skin and Liver mRNA and Protein Expression Levels of AMPK, NF-κBp65, IκB-α, SOD1, and CAT AMPK, NF-κBp65, IκB-α, SOD1, and CAT are all biomarkers of oxidative stress and inflammatory (Yu et al, 2020). Real-time fluorescent quantitative PCR (RT-qPCR) and Western blotting are used to detect the mRNA expression and protein expression of the above genes.…”

Section: Skin Levels Of Related Oxidative Stress Indicators and Inflamentioning

confidence: 99%

Nicotinamide Mononucleotide Combined With Lactobacillus fermentum TKSN041 Reduces the Photoaging Damage in Murine Skin by Activating AMPK Signaling Pathway

Zhou

et al. 2021

Front. Pharmacol.

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Long-term exposure to UVB (280–320 nm) can cause oxidative skin damage, inflammatory injury, and skin cancer. Research on nicotinamide mononucleotide (NMN) and lactic acid bacteria (LAB) with regard to antioxidation, anti-inflammation, and prevention of other age-related diseases has received increasing attention. In the present study, the in vitro antioxidant analysis showed that NMN combined with Lactobacillus fermentum TKSN041 (L. fermentum TKSN041) has a high scavenging ability on hydroxyl (OH), 2, 2′-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid) diammonium salt (ABTS) and 1, 1-diphenyl-2-picrylhydrazyl (DPPH), and it also possess a good total antioxidant capacity. The animal experimental results show that NMN combined with LAB maintained normal liver morphology of mice and reduced pathological damage to murine skin. NMN combined with LAB significantly increased the serum levels of total superoxide dismutase (T-SOD), catalase (CAT), and interleukin (IL)-10, but reduced the levels of malondialdehyde, advanced glycation end products, tumor necrosis factor (TNF)-α, and IL-6. NMN combined with LAB increased T-SOD, CAT, IL-10, Na+-K+-ATPase, and NAD+ levels in the skin, but reduced TNF-α level in the skin. NMN combined with LAB increased the mRNA expression levels of SOD1, CAT, glutathione (GSH), inhibitor of NF-κB (IκB-α), IL-10, AMP-activated protein kinase (AMPK), adaptor protein, phosphotyros ineinteraction, PH domain and leucine zipper containing 1 (APPL1), peroxisome proliferator-activated receptor γ co-activator-1α (PGC-1α), and forkhead transcription factor O (FOXO) in the skin and liver, but decreased the mRNA expression levels of nuclear factor (NF)-κBp65, TNF-α, IL-6, and rapamycin target protein (mTOR). NMN combined with LAB increased the protein expression levels of AMPK, IκB-α, SOD1, and CAT in the skin tissues and reduced protein expression of NF-κBp65. NMN combined with L. fermentum TKSN041 improved murine skin damage caused by UVB irradiation, and the protective mechanism may be related to activation of the AMPK signaling pathway. The results of this study are expected to provide a reference for preventing and the treating skin photoaging.

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“…Adenosine monophosphate-activated protein kinase (AMPK), the main sensor of cellular energy status [21], has been shown to activate silent information regulator of transcription 1 (SIRT1) [22]. It is widely believed that inflammation can be suppressed by the synergistic effects of AMPK and SIRT1 [23]. Furthermore, overexpression of SIRT1 can reduce the inflammatory response via nuclear factor kappa beta (NF-κB) [24], and therefore AMPK/ SIRT1/NF-κB is regarded as a classical inflammatory signaling pathway.…”

Section: Introductionmentioning

confidence: 99%

Liuweidihuang Pill Alleviates Inflammation of the Testis via AMPK/SIRT1/NF‐κB Pathway in Aging Rats

Wang

Zhou

Yang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Liuweidihuang Pill (LP) is a traditional Chinese herbal formula that is often used in clinical practice to treat kidney deficiency syndrome. The present study investigated the antiaging effects of LP in a D-galactose- (D-Gal-) induced subacute aging rat model. The study also attempted to explore whether anti-inflammatory mechanisms that underpin the antiaging effects are mediated by the AMPK/SIRT1/NF-κB signaling pathway. Rats were subcutaneously injected with D-Gal at a dosage of 100 mg/kg/d for 8 weeks. Upon successful induction of aging in the rats, the animal was administered LP at 0.9 g/kg/d by gavage for 4 weeks. Proteins of the testis were subsequently examined by western blot analysis, and associated locations in the testicular tissue were determined by immunohistochemistry. We observed that LP exerted antiaging effects in aging rats following the activation of AMPK/SIRT1. It was also observed that LP inhibited the expression of NF-κB, thereby further attenuating inflammation of the testis. Therefore, LP can alleviate inflammation of the testis via the AMPK/SIRT1/NF-κB pathway in aging rats.

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Role of AMPK/SIRT1-SIRT3 signaling pathway in affective disorders in unpredictable chronic mild stress mice

Cited by 19 publications

References 51 publications

α-Cyperone Confers Antidepressant-Like Effects in Mice via Neuroplasticity Enhancement by SIRT3/ROS Mediated NLRP3 Inflammasome Deactivation

α-Cyperone Confers Antidepressant-Like Effects in Mice via Neuroplasticity Enhancement by SIRT3/ROS Mediated NLRP3 Inflammasome Deactivation

Nicotinamide Mononucleotide Combined With Lactobacillus fermentum TKSN041 Reduces the Photoaging Damage in Murine Skin by Activating AMPK Signaling Pathway

Liuweidihuang Pill Alleviates Inflammation of the Testis via AMPK/SIRT1/NF‐κB Pathway in Aging Rats

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