Role of activin A in carbon tetrachloride-induced acute liver injury

Abstract

These data show that activin A is involved in CCl4-induced acute liver injury. Blocking activin A actions may be a therapeutic approach for acute liver injury.

Hepatoprotective effects of blue honeysuckle on CCl4‐induced acute liver damaged mice

“…BH extracts were shown to have the strongest antioxidant potential among 12 types of colored berries (Chen et al., ) and possess hepatoprotective effects (Palíková et al., ). However, as more detailed studies on these hepatoprotective effects are lacking, we aimed to evaluated the effect of BH extracts against CCl 4 ‐induced acute hepatic damage in mice (Ferreira et al., ; Wang et al., ); we examined three different extract types, BHw, BHj, and BHe, for their suitability as potent hepatoprotective medicinal foods.…”

“…Acute liver damage was induced by single IP injection of CCl 4 (Sigma-Aldrich, St Louis, MO, USA), dissolved in olive oil (Sigma-Aldrich, St Louis, MO, USA) 1:19 (v/v) (5%) in a volume of 10 ml/kg (equivalent to 0.5 ml/kg of CCl 4 ), at 1 h after the seventh administration of the test material in accordance with previously established methods (Al-Sayed, Abdel-Daim, Kilany, Karonen, & Sinkkonen, 2015;Al-Sayed et al, 2014;Fahmy, Al-Sayed, Abdel-Daim, Karonen, & Singab, 2016;Ferreira et al, 2010;Wang et al, 2013). Instead of CCl 4 , equal volumes of olive oils were administered to the intact control mice; further, distilled water was orally administered 1 h after the seventh administration.…”

“…Therefore, the hepatoprotective effects of test materials are evaluated on CCl 4 ‐induced acute liver damage through histopathological analyses and the examination of anti‐inflammatory potential and antioxidative activities (Ferreira et al., ; Wang et al., ).…”

“…Inflammation is another important pathological mechanism through which CCl 4 -induced liver injury is propagated (Ebaid, Bashandy, Alhazza, Rady, & El-Shehry, 2013;Yang et al, 2015). Therefore, the hepatoprotective effects of test materials are evaluated on CCl 4 -induced acute liver damage through histopathological analyses and the examination of anti-inflammatory potential and antioxidative activities (Ferreira et al, 2010;Wang et al, 2013).…”

Endothelial transcription factor KLF2 negatively regulates liver regeneration via induction of activin A

“…After CCl 4 -induced liver injury, activin A expression is elevated, which results in liver fibrosis (8). Blocking the activity of activin A with anti-activin A antibodies after CCl 4 treatment reduces the necrotic area and the secretion of serum transferases (22). However, activin A was also shown to induce the renewal of liver architecture by inducing collagen production in hepatic stellate cells (HSC) and tubulogenesis of LSECs (23,24).…”