1992
DOI: 10.3177/jnsv.38.593
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Abstract: SummaryGlucosone (D-arabino-hexos-2-ulose), a typical enediol prod uct formed both in the Maillard reaction and Tradiolysis of sugars, decreased survival of Chinese hamster lung V79 cells, which were in cubated under MEM for 4h. Inhibition of the decrease in cell servival by catalase and SOD suggests the role of active oxygen species, namely H2O2 and O2-, in the biological effects of glucosone. H2O2 was formed in the medium during oxidative degradation of glucosone. Inhibition of the formation of H2O2 by SOD i… Show more

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Cited by 8 publications
(5 citation statements)
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“…In other words, (+)-catechin scavenged 02-, as has already been reported (Darmon et a/., 1992). One author of this paper has already reported that SOD inhlbited H202 formation in cigarette tar extracts (Nakayama et a/., 1989) reaction products (Nakayama et a/., 1992c). The inhibition of the H202 formation by SOD in these reports and the present studies seems curious, because the function of SOD is the dismutation of 02-resulting in the accelerated formation of H202' We speculate that the reaction of (+)-catechin with 02-results in the formation of a semi-quinone type radical and H202 (the reaction (4) in Fig.…”
Section: Discussionsupporting
confidence: 49%
“…In other words, (+)-catechin scavenged 02-, as has already been reported (Darmon et a/., 1992). One author of this paper has already reported that SOD inhlbited H202 formation in cigarette tar extracts (Nakayama et a/., 1989) reaction products (Nakayama et a/., 1992c). The inhibition of the H202 formation by SOD in these reports and the present studies seems curious, because the function of SOD is the dismutation of 02-resulting in the accelerated formation of H202' We speculate that the reaction of (+)-catechin with 02-results in the formation of a semi-quinone type radical and H202 (the reaction (4) in Fig.…”
Section: Discussionsupporting
confidence: 49%
“…[40][41][42] D-Glucosone has been also reported as an antitumor agent 43,44) and to be cytotoxic on mammalian cells. 45) Mycorrhiza of Pinus densi‰ora formed by T. matsutake has been reported to have antibacterial activity. 46,47) Work is now in progress to identify the localization of the reaction products and the function of the pyranose oxidase in T. matsutake fruit bodies in vivo.…”
Section: Discussionmentioning
confidence: 99%
“…Inhibition of oxidation of the gallocatechins (Table 3) by SOD supports this mechanisms. Inhibition of H 2 O 2 formation by SOD during the oxidation of various compounds has been experimentally proved (Cadenas et al , 1988;Nakayama et al , 1989;Bandy et al , 1990;Nakayama et al , 1992a;Nakayama et al , 1997;Hiramoto et al , 2001). Furthermore, inhibition of pyrogallol oxidation by SOD has been used as an assay for SOD (Marklund & Marklund, 1974 dish) were incubated in 5 ml of HBS with each catechin (100 M) for 30 min in the presence or absence of catalase (2 g/dish) in experiment 1 and SOD (50 units/dish) in experiment 2.…”
Section: Discussionmentioning
confidence: 99%