Role of 7-chloro-4-(phenylselanyl) quinoline as an anti-aging drug fighting oxidative damage in different tissues of aged rats

Prospecting for a quinoline containing selenium for comorbidities depression and memory impairment induced by restriction stress in mice

“…These results demonstrate that 4-PSQ treatment is able to reverse neuronal oxidative damage and modulate the antioxidant defense system. Previously, 4-PSQ showed that it modulated oxidative stress in different experimental models (Pinz et al 2016 , 2018 ; Luchese et al 2020 ; Paltian et al 2020 ; Lemos et al 2021 ; Rodrigues et al 2021 ). These results are supported by a study by Vogt et al ( 2018 ) in which he demonstrated the antioxidant action of 4-PSQ in a cerebral oxidative stress model in mice, and they evidenced that compound action is entirely attributed to the presence of the organoselenium group in the molecule.…”

“…Additionally, the anti-AD effect of 4-PSQ in mice was evidenced (Pinz et al 2018 ), as well as its action in improving the memory of aged rats (Barth et al 2019 ). It should also be noted that the mechanisms related to the effects of 4-PSQ include its antioxidant action (Pinz et al 2016 ; Duarte et al 2017 ; Vogt et al 2018 ; Luchese et al 2020 ), anti-inflammatory effect (Pinz et al 2016 ; Silva et al 2017 ), as well as its ability to modulate the serotonergic, nitrergic, glutamatergic, and cholinergic systems, evidencing the characteristic multi-target of this molecule (Pinz et al 2016 , 2018 ; Reis et al 2017 ; Silva et al 2017 ; Vogt et al 2018 ; Barth et al 2019 ; Paltian et al 2020 ). Furthermore, this compound has already demonstrated the absence of toxicity in mice (Reis et al 2017 ; Salgueiro et al 2017 ), modulation of synaptic plasticity through increased levels of neural cell adhesion molecules, and levels of polysialyltransferase in brain structures of elderly rats (Barth et al 2019 ), besides reducing glutamate uptake in the brain of mice (Reis et al 2017 ).…”

Recent investigations into synthesis and pharmacological activities of phenoxy acetamide and its derivatives (chalcone, indole and quinoline) as possible therapeutic candidates

“…The result displayed that, compounds 125) were exhibited the highest selectivity as anti-inflammatory agents. Furthermore, potent compounds (122)(123)(124) marked potential in-vitro COX-2 inhibitory as compared to the reference celecoxib. In addition, the results showed that compounds (123 and 124) have no significant cytotoxicity on normal cells.…”

“…Nearly two-thirds of the main small molecule drugs have a minimum one aza heterocyclic fragment in their design structures [117]. Whereas nitrogen-based synthetic heterocyclic compounds provide broad therapeutic applications in several medical categories, such as VEGFr-2 inhibitors (91) [118], anti-cancer [119], anti-tubulin (92) [120], anti-inflammatory [121], antiaging [122], anti-tumor (93) [123], anti-influenza [124], anti-tubercular [125], anti-bacterial [126], anti-diabetic [127], anti-dengue virus [128], anti-convulsant and antidepressant [129], promising antioxidant, antifungal and anti-acetylcholinesterase agents (94) [130]. Moreover, they have been widely found as a key structural material and dominate the field of dyestuff synthesis [131], agro-based chemicals [132] and supramolecular chemistry [133].…”

Nutrient evaluation of the seed, pulp, flesh, and peel of spaghetti squash

“…Aliu et al(2012) also showed that there was significant genetic variation in mineral composition of different genotypes of Cucurbita pepo L. The SS seed contained Se, which was not found in the other parts. Accordingly, the edible seed of SS has anti-aging functions and antitumor activity and in addition, it can also enhance human immunity (Mao et al, 2016;Luchese et al, 2020). The most abundant microelements content was found to be highest in the seed, followed by the peel, pulp, and flesh.…”