2016
DOI: 10.2337/dc15-2373
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Role and Determinants of Adherence to Off-loading in Diabetic Foot Ulcer Healing: A Prospective Investigation

Abstract: OBJECTIVEStudies indicate that off-loading adherence is low in patients with diabetic foot ulcers (DFUs), which may subsequently delay healing. However, there is little empirical evidence for this relationship or the factors that influence adherence.RESEARCH DESIGN AND METHODSThis prospective, multicenter, international study of 79 (46 from the U.K. and 33 the U.S.) persons with type 2 diabetes and plantar DFUs assessed the association between off-loading adherence and DFU healing over a 6-week period. Additio… Show more

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Cited by 85 publications
(173 citation statements)
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“…Outcome instruments such as NeuroQol may be more useful to study certain groups and their response to treatment, particularly with regard to distress related to neuropathy (42). Postural instability and pain, as measured from the NeuroQol, are significantly associated with noncompliance with off-loading regimens in patients with diabetes with foot ulcers (45). Identifying emotional distress in patients with diabetes with neuropathy is important because depression is associated with development of an index foot ulcer (46).…”
Section: The Impact Of Dfd On Hrqolmentioning
confidence: 99%
“…Outcome instruments such as NeuroQol may be more useful to study certain groups and their response to treatment, particularly with regard to distress related to neuropathy (42). Postural instability and pain, as measured from the NeuroQol, are significantly associated with noncompliance with off-loading regimens in patients with diabetes with foot ulcers (45). Identifying emotional distress in patients with diabetes with neuropathy is important because depression is associated with development of an index foot ulcer (46).…”
Section: The Impact Of Dfd On Hrqolmentioning
confidence: 99%
“…Guidelines often categorize prevention and treatment as separate issues, and David is treated according to the guidelines. These guidelines recommend using a non-removable device such as TCC to offload and heal plantar foot ulcers [14,34] because many patients show low adherence to wearing removable offloading devices [3540]; they also recommend that therapeutic shoes are used after healing to prevent reulceration [14,34], as the use of non-removable devices is not feasible during remission.…”
Section: New Framework: the Process Perspective On The Dfmentioning
confidence: 99%
“…For example, if the reason for his low adherence to wearing the walker is forgetfulness, a device with audio feedback when the device is not being worn could be useful [47]. If the reason for low adherence is that the walker impairs his balance [35], therapeutic shoes might be more appropriate. The important thing is to tailor the treatment regimen to maximize his chances of being successful and seeing progression of the healing.…”
Section: New Framework: the Process Perspective On The Dfmentioning
confidence: 99%
“…(1) appreciate the importance of our article (2) substantiating the relationship between adherence to off-loading modalities and healing of diabetic foot ulcers (DFUs). Their letter contained several comments regarding our article that we address here.…”
mentioning
confidence: 99%