Rol de la microbiota gastrointestinal en la regulación de la respuesta inmune

Abstract

The role of gut microbiota in the regulation of the immune response (Rev Med Chile 2016; 144: 910-916)

The role of medicinal products in the treatment of inflammatory bowel diseases (IBD) through inhibition of TLR4/NF‐kappaB pathway

“…As is well acknowledged, an inappropriate response of mucosal immune system to the resident microbiota and other noxious antigens results in IBD. In the intestinal tract, host immune system (Alarcón, González, & Castro, 2016) along with the indigenous commensal microorganisms, including fungi, viruses, and bacteria maintain intestinal homeostasis (Hooper, Littman, & Macpherson, 2012). Recently, it has been indicated that TLR4 serve as the hub of immune responses to microbes in the gut.…”

Toll-like Receptors and Inflammatory Bowel Disease

“…As is well acknowledged, IBD results from an inappropriate response of a dysfunctional mucosal immune system to the resident microbiota and other noxious antigens. In intestinal ecology, trillions of indigenous commensal microorganisms, including bacteria, fungi, and viruses ( 8 ), maintain homeostasis along with the elements of the host immune system ( 9 ). However, the introduction of an innate immune defect, for example, epithelial barrier leak and/or mucosal destruction can harm the otherwise beneficial host–microbe balance.…”

Presencia de Escherichia coli intracelular en mucosa intestinal de pacientes con Enfermedad Inflamatoria Intestinal y su asociación con características clínicas y el uso de corticosteroides

“…Estos resultados sugieren que la presencia de bacteria en la mucosa intestinal estaría asociada a EII, probablemente por una alteración en la microbiota intestinal o en la integridad de la barrera epitelial de los pacientes con posibles consecuencias en la regulación de la respuesta inmune local 22 . No obstante, sería interesante proyectar el análisis de la variación del número de bacterias en un protocolo de seguimiento de los pacientes y de su enfermedad, en relación a los período de actividad/ remisión.…”