2015
DOI: 10.1586/14760584.2015.1074043
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Vaccines represent a key building block for establishing a successful and sustainable control strategy against infectious diseases. Vaccine development often depends on the availability of correlates for protection and reliable animal models for the screening, selection and prioritization of potential vaccine candidates. This is performed according to their immunogenicity, efficacy and safety profiles in pre-clinical studies, which are also critical for identification of candidate antigens, selection of an opt… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
13
0

Year Published

2016
2016
2021
2021

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 9 publications
(13 citation statements)
references
References 116 publications
0
13
0
Order By: Relevance
“…For prevention and control of infectious diseases, vaccines are usually considered the most cost-efficient tools to block the transmission of pathogens [ 32 ]. However, the search for candidate antigens is one of the most difficult steps in the process.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…For prevention and control of infectious diseases, vaccines are usually considered the most cost-efficient tools to block the transmission of pathogens [ 32 ]. However, the search for candidate antigens is one of the most difficult steps in the process.…”
Section: Discussionmentioning
confidence: 99%
“…Alpha-actinin, both native and recombinant, can be recognized by sera from women who have been exposed to T. vaginalis . It has been proved to be the most common immunogen with high immunogenicity [ 9 , 24 , 33 ], an essential requirement as a vaccine candidate [ 32 ]. Additionally, there is a very low similarity in amino acid sequences of the epitopes between T. vaginalis α-actinin and the corresponding human actinin homolog [ 21 , 34 ].…”
Section: Discussionmentioning
confidence: 99%
“…In these mice, researchers were able to model immune complex aggregation and extended-dose related ADA formation which closely mirror the phenomena observed in humans [41]. Vaccines are often evaluated in transgenic mice with a humanized haplotype, which has proved to be an effective tool for predicting CD4+ T cell activation [42, 43]. Savvy strategies like these are gradually improving our preclinical in vivo investigations, howbeit animal modeling remains an unreliable predictor of clinically relevant immunogenicity.…”
Section: Immunogenic Risk Factors and The Need For Predictive Toolsmentioning
confidence: 99%
“…Animal models to evaluate human vaccine candidates have been widely utilized in research and development efforts (Gerdts et al, 2007) and are required for regulatory agency approvals (Riese et al, 2015). Unfortunately, animal models used for pre-clinical vaccine efficacy studies have some significant limitations (Centlivre and Combadiere, 2015).…”
Section: Introductionmentioning
confidence: 99%
“…Unfortunately, animal models used for pre-clinical vaccine efficacy studies have some significant limitations (Centlivre and Combadiere, 2015). Rodent models are relatively inexpensive, and there are many reagents available to characterize their immune responses (Riese et al, 2015). The ability to characterize the magnitude of an immunoglobulin or cell mediated response following vaccination of rodents is routine (Schunk and Macallum, 2005).…”
Section: Introductionmentioning
confidence: 99%