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Cited by 34 publications
(23 citation statements)
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“…Their intraepithelial distribution and capacity for recognizing nonprotein antigens, sometimes in a non-major histocompatibility complex-restricted fashion, have led to their consideration as part of the first-line defense against pathogens (23). In humans, large expansion of ␥␦ ϩ T cells after Mycobacterium bovis bacillus Calmette-Guérin vaccination and during infection with Mycobacterium tuberculosis, Listeria monocytogenes, Brucella melitensis, and Ehrlichia chaffeensis suggests their importance in the host response (31,42).…”
Section: Discussionmentioning
confidence: 99%
“…Their intraepithelial distribution and capacity for recognizing nonprotein antigens, sometimes in a non-major histocompatibility complex-restricted fashion, have led to their consideration as part of the first-line defense against pathogens (23). In humans, large expansion of ␥␦ ϩ T cells after Mycobacterium bovis bacillus Calmette-Guérin vaccination and during infection with Mycobacterium tuberculosis, Listeria monocytogenes, Brucella melitensis, and Ehrlichia chaffeensis suggests their importance in the host response (31,42).…”
Section: Discussionmentioning
confidence: 99%
“…By comparison with αβ T cells, these cells exhibit stronger, pleiotropic functional responsiveness, and they lack deficits in IFN-γ production present in neonatal αβ T cells (80). The γδ T cells in infants respond strongly to immunization with bacillus Calmette-Guérin vaccine (81), and environmental factors are likely to shape the neonatal repertoire of γδ T cells (82), with possible long-term consequences for immune functions. Even prior to birth, γδ T cells might protect the developing organism.…”
Section: When and Where γδ T Cell Functions Are Neededmentioning
confidence: 99%
“…We also wished to determine whether gd T cell activation correlates with protection. Our interest to evaluate gd T cells was based on potent mycobacteria-specific activation of gd T cells in 7-month-old infants who had received BCG vaccine at birth (27), and on experimental evidence that suggests an important role in protection against TB, possibly by activating antigen-presenting cells to prime T cell responses (28).…”
mentioning
confidence: 99%