Robust transmission of rate coding in the inhibitory Purkinje cell to cerebellar nuclei pathway in awake mice

Abbasi, Samira; Hudson, Amber E.; Maran, Selva K; Cao, Ying; Abbasi, Ataollah; Heck, Detlef; Jaeger, Dieter

doi:10.1371/journal.pcbi.1005578

Cited by 13 publications

(15 citation statements)

References 55 publications

(110 reference statements)

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“…6E, (mean ± SD) 14.62 ± 12.54 vs 2.87 ± 3.85, Wilcoxon rank sum test, P < 0.001). Firing irregularity was evaluated by the local variation (Lv) of interspike intervals (ISIs) (Abbasi et al, 2017; Mochizuki et al, 2016; Shinomoto, Shima, & Tanji, 2003), and was found to be different between the two groups (Fig. 6C,F): LFNs tend to have larger Lvs than HFNs (0.78 ± 0.18 vs 0.65 ± 0.16, two-sample t-test, P = 0.005).…”

Section: Resultsmentioning

confidence: 99%

“…We averaged a mean number of 3887 ± 1058 spikes. To evaluate firing regularity/irregularity, we calculated the Lv of ISIs (Abbasi et al, 2017; Mochizuki et al, 2016; Shinomoto et al, 2003). The Lv measure was chosen because it represents local spike train variability between two successive ISIs, thus the measure is theoretically independent from firing rate (e.g.…”

Section: Methodsmentioning

confidence: 99%

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Two distinct proprioceptive representations of voluntary movements in primate spinal neurons

Tomatsu

Kim

Confais

et al. 2018

Preprint

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When willingly setting our body in motion, we simultaneously know where and how our limbs are moving. While this indicates that proprioceptive information is readily represented in the neurons of the central nervous system, it is still unclear how. We recorded the activity of spinal neurons with direct projections from muscle spindle afferents in four monkeys, while they performed simple wrist movements. Against the assumption that these spinal neurons act as a simple relay of afferent input, we found the majority (56%) of neurons had firing patterns incongruent with a simple representation of spindle activity, and the minority had congruent patterns. Two groups of neurons showed distinct intrinsic characteristics (spike width, base firing rate and firing irregularity), and distinct control of their input-output gain. These results are the first demonstration that proprioceptive representation is achieved by the coordinated activity of distinct groups of neurons during volitional movement.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Two distinct proprioceptive representations of voluntary movements in primate spinal neurons

Tomatsu

Kim

Confais

et al. 2018

Preprint

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“…CN neurons can follow ongoing movement kinematics (Thach, 1968(Thach, , 1970aArmstrong and Edgley, 1984;Rowland and Jaeger, 2005) and can be entrained by synchronous PCs, as suggested by recordings showing correlated firing of PC and CN neurons (Thach, 1970a,b;Armstrong and Edgley, 1984;McDevitt et al, 1987). Recently, several studies also demonstrated that rate and time coding strategies can be multiplexed (Sudhakar et al, 2015;Abbasi et al, 2017;Brown and Raman, 2018). Our study is in agreement with previous experiments showing that large CN neurons (presumably glutamatergic projection cells) are entrained by synchronous PCs, whereas at high frequencies GABAergic neurons are essentially inhibited (Person and Raman, 2011;Najac and Raman, 2015;Sarnaik and Raman, 2018).…”

Section: Different Coding Strategies In Cn Neurons Of the Medial Nucleusmentioning

confidence: 99%

“…1A). CN neurons seem to sum input rate from PCs and encode some part of the movement as a rate code (Thach, 1968;Armstrong and Edgley, 1984;Brooks and Thach, 2011;Abbasi et al, 2017) or follow the temporal pattern of synchronous PC discharges (Heck et al, 2007;De Zeeuw et al, 2008Raman, 2011, 2012;Sarnaik and Raman, 2018) or pauses (Shin and De Schutter, 2006;Steuber et al, 2007;Hong et al, 2016) as observed in delay eye-blink conditioning (McCormick and Thompson, 1984;Yeo et al, 1997;Rasmussen et al, 2015;Ten Brinke et al, 2015. Indeed, disrupting the temporal pattern of PCs or CN neurons discharges strongly affects motor coordination and leads to ataxia (Hoebeek et al, 2005;Chen et al, 2010;White et al, 2014;White and Sillitoe, 2017).…”

Section: Introductionmentioning

confidence: 99%

Differential Coding Strategies in Glutamatergic and GABAergic Neurons in the Medial Cerebellar Nucleus

et al. 2019

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The cerebellum drives motor coordination and sequencing of actions at the millisecond timescale through adaptive control of cerebellar nuclear output. Cerebellar nuclei integrate high-frequency information from both the cerebellar cortex and the two main excitatory inputs of the cerebellum: the mossy fibers and the climbing fiber collaterals. However, how nuclear cells process rate and timing of inputs carried by these inputs is still debated. Here, we investigate the influence of the cerebellar cortical output, the Purkinje cells, on identified cerebellar nuclei neurons in vivo in male mice. Using transgenic mice expressing Channelrhodopsin2 specifically in Purkinje cells and tetrode recordings in the medial nucleus, we identified two main groups of neurons based on the waveform of their action potentials. These two groups of neurons coincide with glutamatergic and GABAergic neurons identified by optotagging after Chrimson expression in VGLUT2-cre and GAD-cre mice, respectively. The glutamatergic-like neurons fire at high rate and respond to both rate and timing of Purkinje cell population inputs, whereas GABAergic-like neurons only respond to the mean population firing rate of Purkinje cells at high frequencies. Moreover, synchronous activation of Purkinje cells can entrain the glutamatergic-like, but not the GABAergic-like, cells over a wide range of frequencies. Our results suggest that the downstream effect of synchronous and rhythmic Purkinje cell discharges depends on the type of cerebellar nuclei neurons targeted.

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“…Towards these goals, we developed an algorithm based on constructing and manipulating rate templates of recorded neurons and generating gamma-distributed random processes with a refractory period from these rate templates. Our initial use of this algorithm was recently published in a study modeling the processing of Purkinje cell input by the cerebellar nuclei for respiratory related behavioral coding (Abbasi et al, 2017). Here we further refine this algorithm and test it with surrogate data to determine its accuracy and limitations.…”

Section: Introductionmentioning

confidence: 99%

A general method to generate artificial spike train populations matching recorded neurons

2020

Self Cite

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We developed a general method to generate populations of artificial spike trains (ASTs) that match the statistics of recorded neurons. The method is based on computing a Gaussian local rate function of the recorded spike trains, which results in rate templates from which ASTs are drawn as gamma distributed processes with a refractory period. Multiple instances of spike trains can be sampled from the same rate templates. Importantly, we can manipulate rate-covariances between spike trains by performing simple algorithmic transformations on the rate templates, such as filtering or amplifying specific frequency bands, and adding behavior related rate modulations. The method was examined for accuracy and limitations using surrogate data such as sine wave rate templates, and was then verified for recorded spike trains from cerebellum and cerebral cortex. We found that ASTs generated with this method can closely follow the firing rate and local as well as global spike time variance and power spectrum. The method is primarily intended to generate well-controlled spike train populations as inputs for dynamic clamp studies or biophysically realistic multicompartmental models. Such inputs are essential to study detailed properties of synaptic integration with well-controlled input patterns that mimic the in vivo situation while allowing manipulation of input rate covariances at different time scales.

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Robust transmission of rate coding in the inhibitory Purkinje cell to cerebellar nuclei pathway in awake mice

Cited by 13 publications

References 55 publications

Two distinct proprioceptive representations of voluntary movements in primate spinal neurons

Two distinct proprioceptive representations of voluntary movements in primate spinal neurons

Differential Coding Strategies in Glutamatergic and GABAergic Neurons in the Medial Cerebellar Nucleus

A general method to generate artificial spike train populations matching recorded neurons

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