Robust Self-Healing Hydrogels Assisted by Cross-Linked Nanofiber Networks

Fang, Yuan; Wang, Cai‐Feng; Zhang, Zhihong; Shao, Huan; Chen, Su

doi:10.1038/srep02811

Cited by 46 publications

(24 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although this review focuses on nanoparticles in combination with hydrogels, the development principles in above areas can be applied to hydrogels combined with other delivery platforms featuring different sizes, geometries, or dimensions such as microparticles 108 and nanofibers. 21 Overall, NP-gels have emerged as a versatile class of biomaterials, unleashing unique synergistic properties with strong application potential to improve drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery

et al. 2016

View full text Add to dashboard Cite

Nanoparticles have offered a unique set of properties for drug delivery including high drug loading capacity, combinatorial delivery, controlled and sustained drug release, prolonged stability and lifetime, and targeted delivery. To further enhance therapeutic index, especially for localized application, nanoparticles have been increasingly combined with hydrogels to form a hybrid biomaterial system for controlled drug delivery. Herein, we review recent progresses in engineering such nanoparticle-hydrogel hybrid system (namely ‘NP-gel’) with a particular focus on its application for localized drug delivery. Specifically, we highlight four research areas where NP-gel has shown great promises, including (1) passively controlled drug release, (2) stimuli-responsive drug delivery, (3) site-specific drug delivery, and (4) detoxification. Overall, integrating therapeutic nanoparticles with hydrogel technologies creates a unique and robust hybrid biomaterial system that enables effective localized drug delivery.

show abstract

Section: Introductionmentioning

confidence: 99%

Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Alternative polymerization schemes using reduction/oxidation (redox)-initiation systems allow for in situ chemical crosslinking, enabling spontaneous gelation at the site of injection under physiological conditions (Van Tomme, Storm, & Hennink, 2008). Ammonium persulfate (APS)/ N,N,N',N'-tetramethylethylenediamine (TEMED) is a redox initiation system employed ubiquitously in crosslinking of hydrogels (Ahmed, 2013;Desai, Tang, Ross, & Gemeinhart, 2012;Fang, Wang, Zhang, Shao, & Chen, 2013;Hennink & van Nostrum, 2002;Hong, Mao, & Wang, 2006;Mironi-Harpaz, Wang, Venkatraman, & Seliktar, 2012;Suhag, Bhatnagar, & Singh, 2008;Yang et al, 2013). However, potential toxicity concerns have been reported (Desai et al, 2012;Hennink & van Nostrum, 2002;Ifkovits et al, 2010;Mironi-Harpaz et al, 2012) as with other photo-initiation systems (Baroli, 2006;Mironi-Harpaz et al, 2012;Page et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Development of crosslinked methylcellulose hydrogels for soft tissue augmentation using an ammonium persulfate-ascorbic acid redox system

Gold

Varma

Taub

et al. 2015

Carbohydrate Polymers

View full text Add to dashboard Cite

Hydrogels composed of methylcellulose are candidate materials for soft tissue reconstruction. Although photocrosslinked methylcellulose hydrogels have shown promise for such applications, gels crosslinked using reduction-oxidation (redox) initiators may be more clinically viable. In this study, methylcellulose modified with functional methacrylate groups was polymerized using an ammonium persulfate (APS)-ascorbic acid (AA) redox initiation system to produce injectable hydrogels with tunable properties. By varying macromer concentration from 2% to 4% (w/v), the equilibrium moduli of the hydrogels ranged from 1.47 ± 0.33 to 5.31 ± 0.71 kPa, on par with human adipose tissue. Gelation time was found to conform to the ISO standard for injectable materials. Cellulase treatment resulted in complete degradation of the hydrogels within 24h, providing a reversible corrective feature. Co-culture with human dermal fibroblasts confirmed the cytocompatibility of the gels based on DNA measurements and Live/Dead imaging. Taken together, this evidence indicates that APS-AA redox-polymerized methylcellulose hydrogels possess properties beneficial for use as soft tissue fillers.

show abstract

“…Similar to other self-healing polymers, the self-healing hydrogels were developed based on two strategies-intrinsic and extrinsic, where the former has garnered more attention. The extrinsic strategy is applied by incorporation of the modified nanoparticles (Rao et al, 2019) and nanocellulose (Bai et al, 2019) or via the release of healing agents from ruptured micro/nanoscale capsules and fibers (Fang et al, 2013). The intrinsic self-healing ability of hydrogels is mostly induced through the physical non-covalent interactions and reversible chemical covalent bonds.…”

Section: Tailored Hydrogels For Tissue Engineeringmentioning

confidence: 99%

Insight Into the Current Directions in Functionalized Nanocomposite Hydrogels

et al. 2020

View full text Add to dashboard Cite

Since the introduction of tissue engineering as an encouraging method for the repair and regeneration of injured tissue, there have been many attempts by researchers to construct bio-mimetic scaffolds which mimic the native extracellular matrix, with the aim of promoting cell growth, cell proliferation, and restoration of the tissue's native functionality. Among the different materials and methods of scaffold fabrication, one particularly promising class of materials, hydrogels, has been extensively studied, with the inclusion of nano-scaled materials into hydrogels leading to the creation of an exciting new generation of nanocomposites, known as nanocomposite hydrogels. To closely mimic the native tissue behavior, scientists have recently focused on the functionalization of incorporated nanomaterials via chiral biomolecules, with reported results showing great potential. The current article aims to introduce a perspective of nano-scaled cellulose as a promising nanomaterial which can be multi-functionalized for the fabrication of nanocomposite hydrogels with applications in tissue engineering and drug delivery systems. This article also briefly reviews the recently reported literature on nanocomposite hydrogels incorporated with chiral functionalized nanomaterials. Such knowledge paves the path for the development of tailored hydrogels toward practical applications.

show abstract

Robust Self-Healing Hydrogels Assisted by Cross-Linked Nanofiber Networks

Cited by 46 publications

References 41 publications

Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery

Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery

Development of crosslinked methylcellulose hydrogels for soft tissue augmentation using an ammonium persulfate-ascorbic acid redox system

Insight Into the Current Directions in Functionalized Nanocomposite Hydrogels

Contact Info

Product

Resources

About