Journal of the American Statistical Association volume 104, issue 485, P60-75 2009 DOI: 10.1198/jasa.2009.0004 View full text
Richard J. Cook, Jerald F. Lawless, Lajmi Lakhal-Chaieb, Ker-Ai Lee

Abstract: SummaryIn clinical trials featuring recurrent clinical events, the definition and estimation of treatment effects involves a number of interesting issues, especially when loss to follow-up may be eventrelated and when terminal events such as death preclude the occurrence of further events. This paper discusses a clinical trial of breast cancer patients with bone metastases where the recurrent events are skeletal complications, and where patients may die during the trial. We argue that treatment effects should…

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