Journal of the American Statistical Association volume 104, issue 485, P60-75 2009 DOI: 10.1198/jasa.2009.0004 View full text
|
|
Share
Richard J. Cook, Jerald F. Lawless, Lajmi Lakhal-Chaieb, Ker-Ai Lee

Abstract: SummaryIn clinical trials featuring recurrent clinical events, the definition and estimation of treatment effects involves a number of interesting issues, especially when loss to follow-up may be eventrelated and when terminal events such as death preclude the occurrence of further events. This paper discusses a clinical trial of breast cancer patients with bone metastases where the recurrent events are skeletal complications, and where patients may die during the trial. We argue that treatment effects should…

expand abstract