Robust design of binary countercurrent adsorption separation processes

Storti, Giuseppe; Mazzotti, Marco; Morbidelli, Massimo; Carrà, Sergio

doi:10.1002/aic.690390310

Cited by 362 publications

(249 citation statements)

References 8 publications

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“…The separation of xylenes from the aromatic fraction Cs has been studied both in vapor and liquid phase by adsorption on zeolites using the four-section SMB configuration (Storti et al, 1988(Storti et al, , 1989a and the C8 and C5 separation in a six-port SMB pilot plant operating in the vapor phase (Storti et al. 1992: Baciocchi et al, 1995.…”

Section: Introductionmentioning

confidence: 99%

Separation of 1,1′-bi-2-naphthol enantiomers by continuous chromatography in simulated moving bed

Pais

Loureiro

Rodrigues

1997

Chemical Engineering Science

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Abstract--The chromatographic separation of 1,1'-bi-2-naphthol enantiomers with 3,5-dinitrobenzoyl phenylglycine bonded to silica gel stationary phases is studied. Continuous chromatography in simulated moving bed (SMB) is analyzed by modeling, simulation and operation of a SMB pilot unit Licosep 12-26 from Separex (France).A model for the prediction of the cyclic steady-state performance of the SMB is developed based on the analogy with the true moving bed (TMB). The model assumes axial dispersion flow for the liquid phase, linear driving force (LDF) approximation for intraparticle mass transfer rate and takes into account multicomponent adsorption equilibria.The SMB package allows the simulation of the pilot unit. The effect of operating variables (switching time, extract and feed flow rates, section length) and number of mass transfer units on the SMB performance is analyzed. The SMB performance is characterized by purity, recovery, solvent consumption and adsorbent productivity. The package also allows the simulation of the dynamic evolution of internal profiles for the transient operation of a TMB. The operation of the SMB pilot unit was carried out for the separation of racemic mixtures of bi-naphthol enantiomers. Using a 8-column configuration purities as high as 94.5% of the more retained species in the extract and 98.9% of the less retained species in the raffinate were obtained.

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Section: Introductionmentioning

confidence: 99%

Separation of 1,1′-bi-2-naphthol enantiomers by continuous chromatography in simulated moving bed

Pais

Loureiro

Rodrigues

1997

Chemical Engineering Science

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“…Because of the very tight operating domain of the SMB and its highly nonlinear character, the design of a SMB (Storti et al 1993) is delicate. The previous authors have defined design parameters which better represent the SMB separation performance than the usual flow rates.…”

Section: Resultsmentioning

confidence: 99%

Model Predictive Control of a Simulated Moving Bed

Dejardin¹,

Alamir²,

Corriou³

2004

IFAC Proceedings Volumes

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Chromatographic processes for performing difficult separations such as enantiomers separation with high purity are an expanding technology. An interesting alternative to the expensive conventional batch chromatography is the true moving bed, a counter-current continuous process. However, for feasibility reasons, the TMB cannot be realized. The simulated moving bed (SMB) is realized in practice by connecting several single chromatographic columns in series and simulating the movement of solid by cyclic switching of the inlet and outlet ports. The complex dynamics, important non linearity, and multivariable character of the SMB make its control a challenging task. At this stage of the study, model predictive control (MPC) under the form of quadratic dynamic matrix control (QDMC) is applied on the TMB and the SMB. The numerical simulations of reference trajectory tracking performed show that the QDMC is well adapted for TMB control while the control of the SMB remains improvable.

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“…This separation region is the area in a γ 3 × γ 2 plot where both extract and raffinate are pure (γ 2 and γ 3 are the ratios between fluid and solid interstitial velocities in sections 2 and 3, respectively). This plot, first proposed by Morbidelli and coworkers [13,14], is an important tool in the choice of the best operating conditions, providing that the constraints in sections 1 and 4 are fulfilled; that is, the flow rate ratios in sections 1 and 4, γ 1 and γ 4 , are chosen away from their critical values. Figure 7.4 shows a typical γ 3 × γ 2 plot that can be found for a nonlinear TMB separation.…”

Section: Design Of Smb Processesmentioning

confidence: 99%

“…In fact, the original problem represented by a set of partial differential equations will be simplified to a set of ordinary differential equations. Other simplifications that can be introduced consist in neglecting axial dispersion and mass transfer resistances, leading to an equilibrium model [13,14] that, under certain kind of adsorption equilibrium isotherms, can lead to explicit criteria for the choice of the SMB operating conditions for complete separation of a binary mixture.…”

Section: Preparative Enantioselective Chromatographymentioning

confidence: 99%