Robust antimicrobial compounds and polymers derived from natural resin acids

Wang, Jifu; Chen, Yung Pin; Yao, Kejian; Wilbon, Perry A.; Zhang, Wujie; Ren, Lixia; Zhou, Juhua; Nagarkatti, Mitzi; Wang, Chunpeng; Chu, Fuxiang; He, Xiaoming; Decho, Alan W.; Tang, Chuanbing

doi:10.1039/c1cc16432e

Cited by 145 publications

(89 citation statements)

References 31 publications

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“…In addition, Decho and co-workers connected derivatives of resin acids to the poly(ε-caprolactone) as hydrophobic groups (Figure 1b). 35 This kind of polymers, containing resin ring structures, exhibit considerable antimicrobial activities against a broad spectrum of bacteria (MICs: Gram-positive bacteria 0.7-10.1 μM; Gram-negative bacteria 3-40 μM) with high selectivity (HC 50 even higher than 860 μM). From the experiments, they suggested that the great antimicrobial activity was related to the structure of resin acids and hydrophobicity.…”

Section: Monomer Designsmentioning

confidence: 99%

Antimicrobial cationic polymers: from structural design to functional control

Yang

Cai

Huang

et al. 2017

Polym J

207

174

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Antimicrobial cationic polymers mainly contain two functional components: the cationic groups and the hydrophobic groups. The antimicrobial activity is influenced by the type, amount, location and distribution of these two components. This review summarizes the designs and syntheses of antimicrobial cationic polymers by controlling the above two factors. It involves the structural designs from primary to secondary structures, from covalent to noncovalent syntheses and from bulk to surface. Furthermore, it will discuss how to advance structural designs toward functional controls for optimizing the antimicrobial performances and biocompatibility of antimicrobial cationic polymers. It is anticipated that this review will provide some guidelines for developing molecular engineering of antimicrobial cationic polymers with tailor-made structures and functions.

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Section: Monomer Designsmentioning

confidence: 99%

Antimicrobial cationic polymers: from structural design to functional control

Yang

Cai

Huang

et al. 2017

Polym J

207

174

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“…Cellulose is an abundant renewable biopolymer. [39][40][41] DAEMA is a methacrylate-based monomer containing renewable resin acid from rosin, [42][43][44][45][46][47][48][49][50] and LMA is derived from a renewable fatty acid. In our related previous work, we reported the polymerization of DAEMA monomer by ATRP to produce homopolymers and block copolymers with controlled molecular weight and low polydispersity index.…”

Section: -24mentioning

confidence: 99%

Sustainable thermoplastic elastomers derived from renewable cellulose, rosin and fatty acids

et al. 2014

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Two series of graft copolymers, cellulose-g-poly(n-butyl acrylate-co-dehydroabietic ethyl methacrylate) (Cell-g-P(BA-co-DAEMA))and cellulose-g-poly(lauryl methacrylate-co-dehydroabietic ethyl methacrylate) (Cell-g-P(LMA-co-DAEMA)), were prepared by "grafting from" atom transfer radical polymerization (ATRP). In these novel graft copolymers, cellulose, DAEMA (derived from rosin), and LMA (derived from fatty acids) are all sourced from renewable natural resources. The "grafting from" ATRP strategy allows the preparation of high molecular weight graft copolymers consisting of a cellulose main chain with acrylate copolymer side chains. By manipulating the monomer ratios in the P(BA-co-DAEMA)and P(LMA-co-DAEMA) side chains, graft copolymers with varying glass transition temperatures (À50-60 C) were obtained. Tensile stress-strain and creep compliance testing were employed to characterize mechanical properties. These novel graft copolymers did not exhibit linear elastic properties above about 1% strain, but they did manifest remarkable elasticity at strains of 500% or more. These results suggest that these cellulose-based, acrylate side-chain polymers are potential candidates for service as thermoplastic elastomers materials in applications requiring high elasticity without rupture at high strains.

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“…Chemical studies on P. kesiya var. langbianensis have been conducted, and terpenes have been identified as the major component in resin (Wang et al 2012). When the volatile compounds of resin from P. kesiya were examined, the main constituents of resin discovered were α-pinene, β-pinene, β-phellandrene, 3-camphene, myrcene, longifolene, and caryophyllene (Zhao et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Transcriptome Analyses to Reveal Genes Involved in Terpene Biosynthesis in Resin Producing Pine Tree Pinus kesiya var. langbianensis

et al. 2018

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Pinus kesiya var. langbianensis is an important resin resource tree that belongs to the Pinaceae family. It produces a higher yield of resin per year compared to the rest of the pine trees from the same habitat. To identify genes that may be involved in this high resin yield production, the bark transcriptomes of P. kesiya var. langbianensis and a P. kesiya that produce a normal volume of resin were sequenced using RNA-Seq, and their gene expression profiles were compared in regards to specific interest in the resin synthetic metabolism pathways. The results showed that a total of 68,881 transcripts were assembled, 180 of which were involved in terpene metabolism. Surprisingly, in both the transcriptome analysis and the quantitative fluorescent polymerase chain reaction (QF-PCR), nine genes involved in resin biosynthesis were shown to be significantly down-regulated in P. kesiya. In addition, this study provided numerous gene candidates for the further study of resin production in pine trees.

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Robust antimicrobial compounds and polymers derived from natural resin acids

Cited by 145 publications

References 31 publications

Antimicrobial cationic polymers: from structural design to functional control

Antimicrobial cationic polymers: from structural design to functional control

Sustainable thermoplastic elastomers derived from renewable cellulose, rosin and fatty acids

Transcriptome Analyses to Reveal Genes Involved in Terpene Biosynthesis in Resin Producing Pine Tree Pinus kesiya var. langbianensis

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