Intelligent welding parameter control is fast becoming a key instrument for attaining quality consistency in automated welding. Recent scientific breakthroughs in intelligent systems have turned the focus of adaptive welding control to artificial intelligencebased welding parameter control. The aim of this study is to combine artificial neural network (ANN) decision-making software and a machine vision system to develop an adaptive artificial intelligence (AI)-based gas metal arc welding (GMAW) parameter control system. The machine vision system uses a laser sensor to scan the upcoming seam and gather seam profile data. Based on further processing of the seam profile data, welding parameters are optimized by the decision-making system. In this work, the developed system is tested in a multivariable welding condition environment and its performance is evaluated. The quality of the welds was consistent and surpassed the required quality level. Additionally, the heat-affected zone (HAZ) was evaluated by microscopy, X-ray, and scanning electron microscope (SEM) imaging. It is concluded that the developed ANN system is suitable for implementation in automated applications, can improve quality consistency and cost efficiency, and reduce required workpiece preparation and handling.