RNA binding proteins in cardiovascular development and disease

Verma, Sunil K.; Kuyumcu-Martinez, Muge N.

doi:10.1016/bs.ctdb.2024.01.007

Current Topics in Developmental Biology

2024

DOI: 10.1016/bs.ctdb.2024.01.007

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RNA binding proteins in cardiovascular development and disease

Sunil K. Verma,

Muge N. Kuyumcu-Martinez

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2024

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The Biological Mechanisms and Clinical Roles of RNA-Binding Proteins in Cardiovascular Diseases

Lin,

Chu,

et al. 2024

Biomolecules

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RNA-binding proteins (RBPs) have pivotal roles in cardiovascular biology, influencing various molecular mechanisms underlying cardiovascular diseases (CVDs). This review explores the significant roles of RBPs, focusing on their regulation of RNA alternative splicing, polyadenylation, and RNA editing, and their impact on CVD pathogenesis. For instance, RBPs are crucial in myocardial injury, contributing to disease progression and repair mechanisms. This review systematically analyzes the roles of RBPs in myocardial injury, arrhythmias, myocardial infarction, and heart failure, revealing intricate interactions that influence disease outcomes. Furthermore, the potential of RBPs as therapeutic targets for cardiovascular dysfunction is explored, highlighting the advances in drug development and clinical research. This review also discusses the emerging role of RBPs as biomarkers for cardiovascular diseases, offering insights into their diagnostic and prognostic potential. Despite significant progress, current research faces several limitations, which are critically examined. Finally, this review identifies the major challenges and outlines future research directions to advance the understanding and application of RBPs in cardiovascular medicine.

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The Biological Mechanisms and Clinical Roles of RNA-Binding Proteins in Cardiovascular Diseases

Lin,

Chu,

et al. 2024

Biomolecules

View full text Add to dashboard Cite

show abstract

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RNA binding proteins in cardiovascular development and disease

Cited by 1 publication

References 374 publications

The Biological Mechanisms and Clinical Roles of RNA-Binding Proteins in Cardiovascular Diseases

The Biological Mechanisms and Clinical Roles of RNA-Binding Proteins in Cardiovascular Diseases

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