RIZ, the retinoblastoma protein interacting zinc finger gene, is mutated in genetically unstable cancers of the pancreas, stomach, and colorectum

Adverse prognosis of epigenetic inactivation in RUNX3 gene at 1p36 in human pancreatic cancer

“…The 1p36 region is believed to harbour tumour suppressor genes, because previous studies identified frequent allelic imbalance at 1p36 in various types of human cancers (Schwab et al, 1996). RIZ1 and p73 genes are located on 1p36, and LOH was detected at each gene locus in pancreatic cancer (Sakurada et al, 2001;Sphyris et al, 2004). It is thought that these are one of the tumour suppressor genes in pancreatic cancer, and we think that RUNX3 may also be a candidate.…”

Adverse prognosis of epigenetic inactivation in RUNX3 gene at 1p36 in human pancreatic cancer

“…The 1p36 region is believed to harbour tumour suppressor genes, because previous studies identified frequent allelic imbalance at 1p36 in various types of human cancers (Schwab et al, 1996). RIZ1 and p73 genes are located on 1p36, and LOH was detected at each gene locus in pancreatic cancer (Sakurada et al, 2001;Sphyris et al, 2004). It is thought that these are one of the tumour suppressor genes in pancreatic cancer, and we think that RUNX3 may also be a candidate.…”

Altered expression of retinoblastoma protein‐interacting zinc finger gene, RIZ, in human leukaemia

“…Inactivation of the RIZ gene could result either from a deletion mutation of the RIZ gene or from silencing of RIZ1 expression as reported in a variety of human tumours (He et al , 1998; Jiang et al , 1999; Chadwick et al, 2000; Fang et al, 2000, 2001; Jiang & Huang 2000; Piao et al, 2000; Bauer et al, 2001; Sakurada et al, 2001). The observation that forced expression of RIZ1 in human tumour cells could lead to cell cycle arrest in the G2/M junction and/or apoptosis (He et al , 1998; Jiang et al , 1999; Chadwick et al, 2000; Gazzerro et al, 2001), and the RIZ1 gene knock‐out studies in mice, demonstrating a high incidence of a broad spectrum of tumours including diffuse large B‐cell lymphomas (Steele‐Perkins et al, 2001), suggest tumour suppressor activity by RIZ1.…”

Modulation of RIZ gene expression is associated to estradiol control of MCF-7 breast cancer cell proliferation

“…1D). Western blot analysis of the nuclear extracts with a rabbit polyclonal antibodies to RIZ1 (aa [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] showed that a 48-h estradiol treatment produced a marked reduction of the band corresponding to the expected RIZ1 molecular weight (Fig. 1E).…”

Adverse prognosis of epigenetic inactivation in RUNX3 gene at 1p36 in human pancreatic cancer

“…The 1p36 region is believed to harbour tumour suppressor genes, because previous studies identified frequent allelic imbalance at 1p36 in various types of human cancers (Schwab et al, 1996). RIZ1 and p73 genes are located on 1p36, and LOH was detected at each gene locus in pancreatic cancer (Sakurada et al, 2001;Sphyris et al, 2004). It is thought that these are one of the tumour suppressor genes in pancreatic cancer, and we think that RUNX3 may also be a candidate.…”

Altered expression of retinoblastoma protein‐interacting zinc finger gene, RIZ, in human leukaemia

“…Inactivation of the RIZ gene could result either from a deletion mutation of the RIZ gene or from silencing of RIZ1 expression as reported in a variety of human tumours (He et al , 1998; Jiang et al , 1999; Chadwick et al, 2000; Fang et al, 2000, 2001; Jiang & Huang 2000; Piao et al, 2000; Bauer et al, 2001; Sakurada et al, 2001). The observation that forced expression of RIZ1 in human tumour cells could lead to cell cycle arrest in the G2/M junction and/or apoptosis (He et al , 1998; Jiang et al , 1999; Chadwick et al, 2000; Gazzerro et al, 2001), and the RIZ1 gene knock‐out studies in mice, demonstrating a high incidence of a broad spectrum of tumours including diffuse large B‐cell lymphomas (Steele‐Perkins et al, 2001), suggest tumour suppressor activity by RIZ1.…”

Modulation of RIZ gene expression is associated to estradiol control of MCF-7 breast cancer cell proliferation

“…1D). Western blot analysis of the nuclear extracts with a rabbit polyclonal antibodies to RIZ1 (aa [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] showed that a 48-h estradiol treatment produced a marked reduction of the band corresponding to the expected RIZ1 molecular weight (Fig. 1E).…”

Adverse prognosis of epigenetic inactivation in RUNX3 gene at 1p36 in human pancreatic cancer

“…The 1p36 region is believed to harbour tumour suppressor genes, because previous studies identified frequent allelic imbalance at 1p36 in various types of human cancers (Schwab et al, 1996). RIZ1 and p73 genes are located on 1p36, and LOH was detected at each gene locus in pancreatic cancer (Sakurada et al, 2001;Sphyris et al, 2004). It is thought that these are one of the tumour suppressor genes in pancreatic cancer, and we think that RUNX3 may also be a candidate.…”

Altered expression of retinoblastoma protein‐interacting zinc finger gene, RIZ, in human leukaemia

“…Inactivation of the RIZ gene could result either from a deletion mutation of the RIZ gene or from silencing of RIZ1 expression as reported in a variety of human tumours (He et al , 1998; Jiang et al , 1999; Chadwick et al, 2000; Fang et al, 2000, 2001; Jiang & Huang 2000; Piao et al, 2000; Bauer et al, 2001; Sakurada et al, 2001). The observation that forced expression of RIZ1 in human tumour cells could lead to cell cycle arrest in the G2/M junction and/or apoptosis (He et al , 1998; Jiang et al , 1999; Chadwick et al, 2000; Gazzerro et al, 2001), and the RIZ1 gene knock‐out studies in mice, demonstrating a high incidence of a broad spectrum of tumours including diffuse large B‐cell lymphomas (Steele‐Perkins et al, 2001), suggest tumour suppressor activity by RIZ1.…”

Modulation of RIZ gene expression is associated to estradiol control of MCF-7 breast cancer cell proliferation

“…1D). Western blot analysis of the nuclear extracts with a rabbit polyclonal antibodies to RIZ1 (aa [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] showed that a 48-h estradiol treatment produced a marked reduction of the band corresponding to the expected RIZ1 molecular weight (Fig. 1E).…”