Risks and burden of lung cancer incidence for residential petrochemical industrial complexes: A meta-analysis and application

Lin, Cheng‐Kuan; Hsu, Yu-Tien; Christiani, David C.; Hung, Huei-Yang; Lin, Ro-Ting

doi:10.1016/j.envint.2018.09.018

Cited by 27 publications

(27 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, it is also noted that the data we analyzed are mostly regional averaged over large spatial domains and age-undistinguished; thereby, the identified statistical relation may contain unknown degrees of bias [45,46]. In figure S4, we presented evidence that the identified RWV-ILI relationship is more robust for preschool children and the elderly.…”

Section: Discussionmentioning

confidence: 82%

Changing rapid weather variability increases influenza epidemic risk in a warming climate

Liu

Tan

Sun

et al. 2020

Environ. Res. Lett.

View full text Add to dashboard Cite

It is believed that the continuing change in the Earth's climate will affect the viral activity and transmission of influenza over the coming decades. However, a consensus of the severity of the risk of an influenza epidemic in a warming climate has not been reached. It was previously reported that the warmer winter can reduce influenza epidemic caused mortality, but this relation cannot explain the deadly influenza epidemic in many countries over northern mid-latitudes in the winter of 2017-2018, one of the warmest winters in recent decades. Here, we reveal that the widely spread 2017-2018 influenza epidemic can be attributed to the abnormally strong rapid weather variability. We demonstrate, from historical data, that the large rapid weather variability in autumn can precondition the deadly influenza epidemic in the subsequent months in highly populated northern mid-latitudes; and the influenza epidemic season of 2017-2018 was a typical case. We further show that climate model projections reach a consensus that the rapid weather variability in autumn will continue to strengthen in some regions of northern mid-latitudes in a warming climate, implying that the risk of an influenza epidemic may increase 20% to 50% in some highly populated regions in the later 21st century.

show abstract

Section: Discussionmentioning

confidence: 82%

Changing rapid weather variability increases influenza epidemic risk in a warming climate

Liu

Tan

Sun

et al. 2020

Environ. Res. Lett.

View full text Add to dashboard Cite

show abstract

“…Lin et al's (2017) meta-analysis provides the first attempt to pool some of this knowledge base, identifying no significant increase in the rate of lung cancer mortalities along fence-line communities. A revised meta-analysis found that individuals living near petrochemical facilities have a 19% higher risk of developing lung cancer (Lin et al, 2018). The World Health Organisation's semi-systematic review of the petrochemical industry indicates that inadequacies in the evidence base, may in part be addressed with uniform research at a global or continental scale, which provides a framework and set of outcomes that existing and future case studies may be compared to (WHO, 2014).…”

Section: Introductionmentioning

confidence: 99%

Regional inequalities in benzene exposures across the European petrochemical industry: A Bayesian multilevel modelling approach

Jephcote

Mah

2019

Environment International

View full text Add to dashboard Cite

BackgroundPollutants released from the petrochemical industry are thought to increase the risk of mortality in fence-line communities, yet the results from previous studies are often inconsistent and lack a global perspective, hampered by the absence of cohesive cross-country research.ObjectivesTo provide the first Pan-European analysis of benzene exposures from the petrochemical industry, connecting polluting practices to pollution episodes and disparities in regional mortality rates, identifying the measures of best environmental practice to mitigate adverse outcomes.MethodsThe activity, classification and location of onshore petrochemical facilities within EU-28 Member States were extracted from the ‘European Pollutant Release and Transfer Register’ (E-PRTR), which holds records on 31,753 industrial operations for the reporting period of 2007–15. Parent company records were collected from the Moody's Analytics Amadeus database of 487,338 active companies across Europe. The EUROSTAT census provided records of income, life expectancy, and the underlying demographics used to calculate standardised health outcomes based on 9,936 sub-populations within the NUTS2 regions. The European Environment Agency provided ambient concentrations of benzene from 579 air quality stations. Bayesian multilevel models were constructed to account for variability caused by spatial hierarchical structures, uncertainty in the estimates, and to incorporate both individual and group-level influences.ResultsHigher levels of benzene emissions from petrochemical operations, both overall and in terms of specific pollution events, were associated with increased mortality rates for nearby residential populations, particularly in areas with socioeconomic deprivation. We identify uneven patterns of polluting practices within the industry, and locations that require epidemiological studies.ConclusionsWhile petrochemical facilities in all European Union regions are regulated to be compliant with the annual average benzene limit of 5 μg/m3, uneven exposures still present regional health inequalities. We recommend extending benzene regulations to an hourly or daily limit, alongside the strengthening of regulation for other toxic petrochemical releases.

show abstract

“…Lung cancers are classified based on histology (6), which is important to determine both management and prognostic prediction. The three main subtypes of non-small cell lung cancer (NSCLC) include adenocarcinoma, squamous-cell carcinoma and large-cell carcinoma (7). In spite of the significant advance in diagnostic and therapeutic strategies, the resistance to existing therapies still remains a huge challenge.…”

Section: Introductionmentioning

confidence: 99%

Combination of pembrolizumab and 125I attenuates the aggressiveness of non‑small cell lung cancer

et al. 2020

View full text Add to dashboard Cite

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-associated mortality. Therapies targeting programmed cell death 1 ligand 1 (PD1L1) have promising effects on NSCLC. However, resistance to targeted therapy has become the main problem and the underling molecular mechanism remains unclear. In the present study, the expression of PD1L1 in NSCLC was determined and the association with clinicopathological characteristics was analyzed. A combination therapy was also constructed, including pembrolizumab (Pem) and iodine-125 ( 125 I), which represented an efficient strategy for the treatment of NSCLC. The expression of PD1L1 was upregulated in NSCLC tissues and positively correlated with the Ki-67 index, pathological subtypes and risk stages. A higher level of PD1L1 expression was associated with poorer survival in patients with NSCLC, which could be used as a prognostic indicator. When NSCLC cells were cultured in the presence of Pem and 125 I seeds, the combination treatment significantly abrogated the tumor proliferation and aggressiveness through the inhibition of matrix metalloproteinase-2 and -9 secretion. Flow cytometry analysis revealed pembrolizumab combined with 125 I contributed to a higher rate of apoptosis and cell cycle arrest, indicating that the combination treatment improved the resistance to immunotherapy. Furthermore, the associated molecular mechanism was the dysregulation of ADAM metallopeptidase domain 17. The findings from the present study revealed that PD1L1 could be used as a predictive biomarker, and the application of combination treatment of pembrolizumab and 125 I showed promising effects on NSCLC.Abbreviations: PD1L1, programmed cell death 1 ligand 1; ADAM17, ADAM metallopeptidase domain 17; RT-qPCR, reverse transcriptase-quantitative polymerase chain reaction; PI, propidium iodide; MMP, matrix metalloproteinase; FCM, flow cytometry Key words: non-small cell lung cancer, programmed cell death 1 ligand 1, iodine-125, targeted therapy

show abstract

Risks and burden of lung cancer incidence for residential petrochemical industrial complexes: A meta-analysis and application

Cited by 27 publications

References 30 publications

Changing rapid weather variability increases influenza epidemic risk in a warming climate

Changing rapid weather variability increases influenza epidemic risk in a warming climate

Regional inequalities in benzene exposures across the European petrochemical industry: A Bayesian multilevel modelling approach

Combination of pembrolizumab and 125I attenuates the aggressiveness of non‑small cell lung cancer

Contact Info

Product

Resources

About