Risk of subsequent primary malignancies after dermatofibrosarcoma protuberans diagnosis: A national study

Kurlander, David E.; Martires, Kathryn J.; Chen, Yanwen; Barnholtz‐Sloan, Jill S.; Bordeaux, Jeremy S.

doi:10.1016/j.jaad.2012.10.040

Cited by 13 publications

(13 citation statements)

References 39 publications

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“…Dermatofibrosarcoma protuberans (DFSP) is an uncommon soft tissue sarcoma with low to intermediate malignant potential . It can be locally aggressive and has a tendency to recur, yet prognosis is excellent with a 99% 10‐year survival . DFSP classically presents in the second to fifth decades of life as a slowly growing, skin‐colored or red–brown keloidal plaque on the trunk, though congenital onset, atypical morphologies, and acral location have been reported .…”

Section: Discussionmentioning

confidence: 99%

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Childhood onset atrophic plaque on the chest of a woman with history of acral lentiginous melanoma

2019

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Section: Discussionmentioning

confidence: 99%

“…DFSP classically presents in the second to fifth decades of life as a slowly growing, skin‐colored or red–brown keloidal plaque on the trunk, though congenital onset, atypical morphologies, and acral location have been reported . More recently, a link between DFSP and subsequent primary malignancies has been recognized …”

Section: Discussionmentioning

confidence: 99%

Childhood onset atrophic plaque on the chest of a woman with history of acral lentiginous melanoma

2019

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“…18 There also is evidence that survivors of childhood soft tissue sarcomas experience some of the highest SMN rates observed among survivors of childhood cancer. 7,11,18-21 SEER data were previously used to reveal an increased SMN risk in survivors of Ewing sarcoma, 21 osteosarcoma, 11 rhabdomyosarcoma, 7 and dermatofibrosarcoma.…”

Section: Discussionmentioning

confidence: 99%

Second malignancy risk among pediatric, adolescent, and young adult survivors of fusion‐positive and fusion‐negative sarcomas: Results from the SEER database, 1992 through 2012

Lupo

Brown

Hettmer

2016

Cancer

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“…A recent analysis of the SEER database by Kurlander et al, revealed an increased risk of subsequent primary malignancy (SPM) in patients with primary DFSP [8]. Male patients with DFSP were found to have a 25% increased risk of developing an SPM, with a 21-fold increased risk of non epithelial skin cancers, many of which were DFSP.…”

Section: Discussionmentioning

confidence: 99%

“…Our male patient should undergo thorough dermatologic screening for de novo DFSP lesions every three to six months as his risk of developing a third malignancy is increased. Female patients can consider increased screening for breast malignancies, melanoma, and soft tissue, although the data is less conclusive for this recommendation [8].…”

Section: Discussionmentioning

confidence: 99%

Multifocal Dermatofibrosarcoma Protuberans

Myssiorek¹,

Berman²,

Sanfilippo³

2016

IJCEO

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IntroductionDermatofibrosarcoma protuberans (DFSP) is a superficial sarcoma stemming from fibroblastic and myofibroblastic differentiation within the dermis and underlying soft tissue. It is a very rare tumor with less than 4.5 cases per million persons per year in the US [1]. Between 16 and 20% of the cases of DFSP may be associated with previous traumatic events ranging from mild ulcerations to bayonet stabbing [2]. Most cases of DFSP (47%) occur in the trunk region, however roughly 10% of cases can be found in the head and neck region and 8% in the shoulder region [3]. Metastasis is a rare occurrence, with a rate of roughly 2% over ten years, and usually occurs in the lung, brain, or bone [4]. DFSP has the propensity to recur locally especially within the head and neck region where wide local excision is difficult to obtain without significant morbidity. Given the high risk of local recurrence adjuvant therapy in the form of radiation has grown in practice.Cases of multicentric DFSP are exceptionally rare, with only a few case reports available in the literature. The following case report describes a patient who had concurrent lesions of DFSP of a multifocal nature, one possibly precipitated by trauma and the other with no apparent causative injury. Case HistoryA 47 year old patient presented with simultaneous lesions of the left mastoid region and right shoulder. These lesions were subcutaneous and not tender. Roughly 20 years prior to presentation, he was struck in the back of the head with a baseball bat and subsequently developed a firm swelling over his left mastoid bone posteriorly. The lesion was removed 18 years after it initially appeared. The pathology of this specific lesion was reportedly benign. Surgical excision and pathological investigation were conducted at an outside hospital and no records were able to be obtained. In 2007, the patient was again struck in the back Abstract Background: Dermatofibrosarcoma Protuberans (DFSP) is an exceptionally rare soft tissue tumor that spreads locally with rare metastasis limited to brain, lung, and liver. Immunocompetent patients presenting with more than one DFSP are rare. Methods and Results: A 47 year old man presented with metachronous lesions of the left mastoid skin and right supraclavicular fossa skin. Biopsies revealed DFSP in both locations. CT scans never showed bony invasion in either location. Multiple excisions and radiation therapy have resulted in no recurrence at the supraclavicular site and recurrence in the mastoid site. Conclusions: DFSP can recur despite wide and deep excision combined with radiation therapy. The treatment algorithm for DFSP in the Head and Neck region is included in our review of the literature. Long term follow up is mandatory in these patients.

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Risk of subsequent primary malignancies after dermatofibrosarcoma protuberans diagnosis: A national study

Cited by 13 publications

References 39 publications

Childhood onset atrophic plaque on the chest of a woman with history of acral lentiginous melanoma

Childhood onset atrophic plaque on the chest of a woman with history of acral lentiginous melanoma

Second malignancy risk among pediatric, adolescent, and young adult survivors of fusion‐positive and fusion‐negative sarcomas: Results from the SEER database, 1992 through 2012

Multifocal Dermatofibrosarcoma Protuberans

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