Risk of Squamous Cell Carcinoma and Methoxsalen (Psoralen) and UV-A Radiation (PUVA)

Risk of Malignancies in Psoriasis Patients Treated with Cyclosporine: a 5 y Cohort Study

“…Among the 21 patients who developed nonmelanoma skin cancer 20 (95%) had previously received PUVA. This is in line with the results of a recent meta-analysis that indicated PUVA is the major skin carcinogen in psoriasis patients; high exposure being associated with a 14 -fold higher incidence of SCC (Stern and Lunder, 1998).…”

Incidence and Risk Factors Associated with a Second Squamous Cell Carcinoma or Basal Cell Carcinoma in Psoralen + Ultraviolet A Light-treated Psoriasis Patients

“…Greater exposure to PUVA before a ®rst tumor was signi®cantly and strongly related to risk of second SCC (p < 0.01) but only marginally associated with risk of a second BCC (p = 0.07). These ®ndings accord with results from ®rst tumor studies in our cohort and other PUVA-treated psoriasis cohorts, which have found that PUVA increases SCC risk more than it does BCC risk (Stern and Lange, 1988;Forman et al, 1989;Bruynzeel et al, 1991;Chuang et al, 1992;Stern and Laird, 1994;Stern and Lunder, 1998).…”

Risk of cutaneous carcinogenesis with phototherapy in Indian subpopulation: A 10‐year analysis and a review of literature

“…Murase et al, in a review on the effect of phototherapy in the non‐Caucasian population, analyzed six studies involving 4294 patients with a follow‐up period ranging from 1.2 to 14 years, concluded that the combined relative risk (of both light and dark‐skinned non‐Caucasian population) of patients receiving PUVA developing NMSC was 0.86, thus indicating that Asian and Arabian‐African population is relatively resistant to developing cutaneous malignancy following long‐term phototherapy 25 . Table 2 illustrates the comparison of our study with other similar studies 10–12,15,19,23,26,27 …”