Risk of second primary cancer among women with breast cancer: A population-based study in Granada (Spain)

Molina‐Montes, Esther; Pollán, Marina; Payer, Tilman; Molina, Elena; Dávila-Arias, Cristina; Sánchez, María‐José

doi:10.1016/j.ygyno.2013.04.057

Cited by 44 publications

(79 citation statements)

References 31 publications

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“…Published data indicate that age as well as menopausal status at diagnosis of breast cancer are important predictors of second primaries [16,[24][25][26][27][28][29][30][31][32][33][34]. Langballe et al, who investigated the risk of second malignancies in relation to menopausal status in women with breast cancer, noted that premenopausal women had an 18% increase in risk of appearance of second malignancy and this increased risk was confined to endometrial and ovarian cancers.…”

Section: Discussionmentioning

confidence: 99%

“…The risk of second primaries also depends on patient age and the amount of time elapsed since anticancer therapy [3,4,[14][15][16]. According to data published by Lee et al, the 30-year overall cumulative incidence of second malignancies amounts to 5.2% for children (aged ≤ 14 years), 13.9% for adolescents and young adults (aged 15-39 years) and 16.8% for adults (aged ≥ 40 years) [4].…”

Section: Introductionmentioning

confidence: 99%

“…Breast cancer is the most common cancer in women; in 2012 it was diagnosed in 1.7 million women in the world, and in 17 thousand women in Poland [17,18]. In these patients, continuously improving survival rates have been observed and, therefore, after effective therapy, the majority of them become longterm survivors with elevated risk of occurrence of second malignancies [16,19,[20][21][22].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The characteristics of breast cancer patients with metachronous primary malignancies

Sas-Korczyńska¹,

Kamzol²,

Kołodziej-Rzepa³

et al. 2017

Nowotwory. Journal of Oncology

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Introduction. The risk of developing subsequent primary cancers varies from 1% to 18% and it depends on the type of first cancer and treatment methods applied. Considering the time of occurrence, multiple primary cancers generally fall into two categories: synchronous and metachronous. In breast cancer patients, 10.5% developed multiple primary cancers, from which 23.8% had synchronous, 79% had metachronous and the remaining 2.8% had both synchronous and metachronous malignancies. In patients with breast cancer, elevated risk is observed especially in the development of contralateral breast cancer, endometrial cancer, esophageal cancer, ovarian cancer and thyroid cancer. Aim. This paper presented the characteristics of breast cancer patients with metachronous primary malignancies in relation to the type of metachronous primaries (breast versus non-breast) and to analyse the impact of the type of metachronous cancers on survival rate. Material and methods. Among patients treated for breast cancer between 1963 and 2010, 354 patients (2.1%) developed metachronous primary malignancies and these made up 13.8% of all patients with multiple primary cancers. The mean age at diagnosis of the first breast cancer was 53 ± 11.5 years; positive family cancer history was noted in 127 patients (35.9%). Metachronous malignancies are defined as primaries following the diagnosis of breast cancer in a time interval greater than or equal to than 6 months. In our group, the mean time interval between the diagnosis of breast cancer and the appearance of metachronous malignancies was 100.9 ± 74.9 months (range: 6-543 months, median: 83 months). For comparison of the two groups (patients with second breast vs non-breast cancer) we used the Pearson's Chi-square test for independence (for categorized variables) and variance analysis with Student's t-test (for continuous variables). The survival rate was evaluated with the Kaplan-Meier method, and the log rank test was applied to assess the influence of some factors on the evaluated results. The significance level at α = 0.05 was adopted for all statistical analyses. Results. The probability of occurrence of new cancer averaged from 38.1% to 67.8% for 5 and 10 years after diagnosis of first breast cancer, respectively. In our group, 380 cases of metachronous carcinomas were noted in 354 analysed patients. The most frequent metachronous malignancy was breast cancer (194 cases -54.8%), which occurred as second (192 cases) or third (2 cases) cancer. Patients with contralateral breast cancer in comparison to other types of metachronous malignancies were significantly (p < 0.05): younger (under 50 years: 56.2% vs 34.4%), premenopausal (69.6% vs 48.8%), had a lobular type of first breast cancer (6.7% vs 1.3%), and rarely received tamoxifen (25.3% vs 48.2%). The type of metachronous cancers significantly influenced survival rate: 10-year overall survival rates were 80.1% vs 67.8%, (p = 0.0271). Conclusions. The risk of occurrence of second malignancies in breast cancer survivors makes early dete...

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The characteristics of breast cancer patients with metachronous primary malignancies

Sas-Korczyńska¹,

Kamzol²,

Kołodziej-Rzepa³

et al. 2017

Nowotwory. Journal of Oncology

View full text Add to dashboard Cite

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“…Adenosquamous carcinoma is one of the types of metaplastic carcinoma that are characterized by the presence of non-epithelial cellular elements (4). Following diagnosis, and due to right axillary lymph nodes metastases, treatment options included MRM and combination chemotherapy [a combination of taxotere (160 mg) and carboplatin (6 AUC; mg/ml/min)/trastuzumab (6 mg/kg)] for 6 cycles], followed by IFRT, and again, a continuation of the targeted therapy with trastuzumab.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the incidence of any second malignancy following AML is 2.43% (3). Second primary breast cancer generally develops in women who are first diagnosed with endometrial colon/rectal, stomach, ovarian, thyroid gland or skin cancers, although its occurrence following AML is rare (4). Additionally, adenosquamous carcinoma of the breast is a rare tumor that exists as one of the subgroups of metaplastic breast carcinoma (5).…”

Section: Introductionmentioning

confidence: 99%

Atypical breast adenosquamous carcinoma following acute myeloid leukemia in a middle-aged woman: A case report

Hashemi

Shan²,

Jahantigh

et al. 2017

Molecular and Clinical Oncology

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Abstract. Adenosquamous carcinoma of the breast is a rare cancer that develops as glands and tubules admixed with solid nests of squamous cells in a spindle cell background. Furthermore, its occurrence following AML is also rare. To the best of our knowledge, based on a review of the relevant literature, thus far there have not been any welldocumented cases. In the present case report, we report on a middle-aged woman with a 2year history of acute myeloid leukemia (AML) who was admitted to hospital due to a mass in the right breast, with concurrent cutaneous lesions on the breast. The clinical and pathological investigations resulted in the diagnosis of adenosquamous carcinoma of the breast. The patient underwent a modified radical mastectomy (MRM). Subsequently, the patient received chemotherapy, involved-field radiation therapy and target therapy. At 9 months after the final cycle of chemotherapy, and while she was on targeted therapy with trastuzumab (6 mg administered every 3 weeks), the patient presented with extensive dermatomal skin lesions. A biopsy report revealed metastatic lesions of invasive ductal carcinoma in the abdomen, so chemotherapy resumed with a course lasting for 6 cycles, with the identical treatments, but lacking trastuzumab.

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Factors associated with the onset and survival of subsequent primary breast cancer in female non‐metastatic breast cancer survivors

Liang,

Xiang,

Jia

et al. 2024

Precision Medical Sciences

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This study aimed to investigate the risk factors for the onset of subsequent primary breast cancer (SPBC) in women with a previous diagnosis of early‐stage breast cancer (BC) and to construct a prognostic prediction model for patients with SPBC. Using the Surveillance, Epidemiology, and End Results‐17 (SEER‐17) database, we conducted a retrospective cohort analysis on women with initial primary early‐stage BC from 2004 to 2015. Standardized incidence ratio (SIR) was calculated to determine the risk of subsequent primary cancer (SPC). A competing risk model was built to identify the risk factors for the onset of SPBC. And risk factors associated with breast cancer‐specific mortality in SPBC patients were evaluated and presented in the form of nomogram. Compared with the general population, the overall risk of SPC for all sites was significantly elevated in women with early‐stage BC (SIR = 1.21, 95% CI: 1.20–1.23), and breast is the most frequent site. Age, race and ethnicity, year of diagnosis, history of other tumors, histological type, surgery, radiation, chemotherapy, tumor size, positive lymph nodes numbers and ER status were independent risk factors (p < .05) for the onset of SPBC. A new prognosis nomogram demonstrated good discrimination after internal validation with a C‐index of 0.869 (95% CI: 0.859–0.880), and showed favorable consistency and clinical usefulness. The incidence of SPBC and prognosis of patients with SPBC were well estimated based on a large cohort. Our nomogram model had excellent prediction performance and could be a useful tool to predict prognosis.

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Risk of second primary cancer among women with breast cancer: A population-based study in Granada (Spain)

Cited by 44 publications

References 31 publications

The characteristics of breast cancer patients with metachronous primary malignancies

The characteristics of breast cancer patients with metachronous primary malignancies

Atypical breast adenosquamous carcinoma following acute myeloid leukemia in a middle-aged woman: A case report

Factors associated with the onset and survival of subsequent primary breast cancer in female non‐metastatic breast cancer survivors

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