Risk of Second Malignancies After Adjuvant Radiotherapy for Breast Cancer: A Large-Scale, Single-Institution Review

Kirova, Youlia; Gambotti, Laëtitia; Rycke, Yann De; Vilcoq, J.R.; Asselain, Bernard; Fourquet, A.

doi:10.1016/j.ijrobp.2006.12.011

Cited by 139 publications

(91 citation statements)

References 40 publications

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“…Our data show that RT is associated with a 60% lower risk for BC events in DIN2-DIN3 patients irrespective of ER status, consistent with the meta-analysis of the large phase III trials, where RT resulted in a lower recurrence rate for ipsilateral and invasive breast cancer, by 60% and 55%, respectively [9]. Although every subset of patients seemed to benefit from RT in terms of recurrence, this treatment has not yet provided a survival advantage and may have some long-term toxicity [28]. In addition, given the high NNT, the best subset of subjects who clearly benefit from RT is yet to be defined.…”

Section: Discussionsupporting

confidence: 77%

Ductal Intraepithelial Neoplasia: Postsurgical Outcome for 1,267 Women Cared for in One Single Institution over 10 Years

Guerrieri-Gonzaga¹,

Botteri²,

Rotmensz³

et al. 2009

The Oncologist

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Target audience: Physicians who wish to advance their current knowledge of clinical cancer medicine in breast cancer. LEARNING OBJECTIVES1. Summarize the main risk factors for breast cancer recurrence in patients with DIN.2. Evaluate the role of radiotherapy in patients with DIN.3. Compare the potential benefit of treating patients with low-dose tamoxifen with the risks and benefits of other treatments.This article is available for continuing medical education credit at CME.TheOncologist.com. CME CME ABSTRACTIntroduction. Diagnosis of breast ductal intraepithelial neoplasia (DIN) has increased over the last decades, but

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Section: Discussionsupporting

confidence: 77%

Ductal Intraepithelial Neoplasia: Postsurgical Outcome for 1,267 Women Cared for in One Single Institution over 10 Years

Guerrieri-Gonzaga¹,

Botteri²,

Rotmensz³

et al. 2009

The Oncologist

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“…Multiple other factors have sporadically been shown to affect prognosis, including grade and margin status, although the size of previous studies has made the drawing of definitive conclusions difficult. The major aetiological factor that is implicated in the development of breast sarcoma is previous irradiation of the breast after treatment for a prior malignancy [8][9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

Treatment for breast sarcoma: A large, single-centre series

Pencavel

Allan

Thomas

et al. 2011

European Journal of Surgical Oncology (EJSO)

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Please cite this article as: Pencavel T, Allan CP, Thomas M, Hayes A. Treatment for breast sarcoma: a large, single-centre series., European Journal of Surgical Oncology (2011Oncology ( ), doi: 10.1016Oncology ( / j.ejso.2011 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Breast sarcoma. Conflict of Interest:The authors are not aware of any competing or conflicting interest in the preparation of this manuscript. Synopsis:Breast sarcoma is a rare condition. This large series evaluates prognostic factors from the standpoint of a large tertiary referral centre. Previous breast irradiation emerges as the factor most strongly associated with poorer prognosis; other factors are also discussed. M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT AbstractBackground

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“…Some large series have been published that included 32 to 948 patients identified with RAS. 4,[18][19][20][21][22][23] Most of those reports dealt with epidemiology rather than treatment options, and others focused on specific tumor types. The prognosis for patients with RAS is poor and is comparable to the prognosis for patients with sporadic soft tissue sarcoma according to most authors, although Gladdy et al reported a worse prognosis for 130 patients who had RAS compared with their entire cohort of >7000 patients who had sporadic soft tissue sarcomas.…”

Section: Discussionmentioning

confidence: 99%

Reirradiation and hyperthermia for radiation‐associated sarcoma

Jong

Oldenborg

Oei

et al. 2011

Cancer

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BACKGROUND:The objective of this study was to evaluate the role of reirradiation and hyperthermia in the treatment of radiation-associated sarcoma (RAS) in the thoracic region, which is an increasing, yet extremely rare condition with a poor prognosis. METHODS: Between 1979 and 2009, 16 patients with RAS in the thoracic region were treated in the Academic Medical Center and the Institute Verbeeten with reirradiation and hyperthermia. In 13 patients, this treatment was given for unresectable disease and 3 times after resection as adjuvant treatment. The median latency period between the original malignancy diagnosis and the RAS diagnosis was 86 months (range 19-212 months). Histology was angiosarcoma in 11 patients (69%). The literature on reirradiation with or without hyperthermia for RAS was reviewed. RESULTS: The median survival was 15.5 months (range, 3-204 months). Four patients were not evaluable for response. The response rate for the remaining 12 patients was 75% (7 complete responses and 2 partial responses). Six patients remained free of local failure until death (5 months and 7 months) or last follow-up (8 months, 11 months, 39 months, and 68 months). CONCLUSIONS: The current study indicates that combined reirradiation and hyperthermia for RAS in the thoracic region is feasible. The high response rate and the possibility of durable local control suggest that this treatment is promising. Cancer 2012;118:180-

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Risk of Second Malignancies After Adjuvant Radiotherapy for Breast Cancer: A Large-Scale, Single-Institution Review

Cited by 139 publications

References 40 publications

Ductal Intraepithelial Neoplasia: Postsurgical Outcome for 1,267 Women Cared for in One Single Institution over 10 Years

Ductal Intraepithelial Neoplasia: Postsurgical Outcome for 1,267 Women Cared for in One Single Institution over 10 Years

Treatment for breast sarcoma: A large, single-centre series

Reirradiation and hyperthermia for radiation‐associated sarcoma

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