Risk of osteomyelitis of the jaw induced by oral bisphosphonates in patients taking medications for osteoporosis: A hospital-based cohort study in Japan

Osteonecrosis of the jaws in patients assuming oral bisphosphonates for osteoporosis: A retrospective multi-hospital-based study of 87 Italian cases

“…Japanese authors [57] have recently identified a risk of b1% for 4129 patients regarding osteomyelitis of the jaw due to oral BP, underlying that the use of BPs may increase the risk of osteomyelitis more than with other osteoporosis medications. Other authors [12] have recently described a total of 310 patients with BRONJ from oral BP, after a Pub-Med-based search of case series with a minimum number of 10 subjects.…”

Genetic and acquired factors influencing the effectiveness and toxicity of drug therapy in osteoporosis

“…The incidence of ONJ in the osteoporosis patient population is much lower than in those with cancer. In a Japanese series, the absolute frequency of ONJ among patients with osteoporosis was 0.5-1% in those treated with oral bisphosphonates and 0.1-0.2% in those treated with other drugs (odds ratio 5; 95% confidence interval 2-13) [83 ] . In a recent review, the cumulative incidence of ONJ in the osteoporosis population has been estimated to be in the range of 1-90 per 100,000 patient-years of exposure to bisphosphonates [82 ] .…”

A pragmatic method for electronic medical record-based observational studies: developing an electronic medical records retrieval system for clinical research

“…Application to clinical research We applied the system to a hospital-based cohort study performed at our hospital titled 'Risk of osteomyelitis of the jaw induced by oral bisphosphonates (BP) in patients taking medications for osteoporosis: a hospitalbased cohort study in Japan', 47 in which we identified eligible patients, extracted research data and evaluated the feasibility of our system. The ethics committee at Kyoto University Hospital approved this research.…”

“…A different paper details the purpose, methods, results and discussion of this research. 47 This research aimed to estimate the risks for osteomyelitis of the jaw in osteoporosis patients at our hospital who had been exposed to oral BP compared with those who had not. 48 49 The eligibility criteria were as follows: Inclusion criteria: ▸ Patients diagnosed with osteoporosis and treated with osteoporosis medications at Kyoto University Hospital between November 2000 and October 2010.…”

“…In this test research, two oral and maxillofacial surgeons diagnosed cases by a chart review with an observation of imaging findings. 47 Systemic evaluation To evaluate our system, we collected information about the research period using the recall method. For the accuracy of the data collected by the ERS, we evaluated the results after they were confirmed by the investigator.…”