Risk of birth defects increased in pregnancies conceived by assisted human reproduction

El-Chaâr, Darine; Yang, Qian; Gao, Jun; Bottomley, Jim; Leader, Arthur; Wen, Shi Wu; Walker, Mark

doi:10.1016/j.fertnstert.2008.08.080

Cited by 83 publications

(62 citation statements)

References 32 publications

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“…Lastly, the incidence of malformations found the most frequent being those of the musculoskeletal system followed by malformations of the circulatory system and third, the digestive system, as has also been reported elsewhere [8,29]. We found an incidence of 11.7 % for prematurity in singleton pregnancies, similar to the rate reported for the general Spanish newborn population in 2004 (9.4 %), (n.b: 2.1 % of that population consisted of multiple pregnancies.…”

Section: Discussionsupporting

confidence: 76%

Impact of assisted reproduction treatments on Spanish newborns: report of 14,119 pregnancies

Ricciarelli¹,

Bruna

Verdú³

et al. 2013

J Assist Reprod Genet

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Purpose To investigate neonatal malformation, prematurity, and stillbirth in singleton and multiple pregnancies derived from different Assisted Reproductive Techniques (ART). Methods In this prospective cohort study data were collected, from private and public Spanish IVF units, during the years 2008 and 2009. During this period, 8,682 pregnancies were analysed from the initial 14,119 pregnancies reported. Pregnancies included in the study derived from IUI (n=1,065), IVF (n=838), ICSI (n=5,080), FET (n=1,404) and PGD (n=295). This first analysis focuses primarily on neonatal malformation, prematurity, and stillbirth both in singleton and multiple pregnancies derived from different ART. Malformations were classified according to the WHO ICD 10 code. Results Malformations were found in 0.83 % of our newborns. No differences in malformations were observed between singletons or multiples independently of the ART used. There was a significant difference in prematurity rate among singletons depending on treatment but this association was not observed in multiple pregnancies. Stillbirth was significantly lower in singleton (0.72 %) than in multiple pregnancies (1.82 %). Conclusions The percentage of malformations observed in ART newborns was similar to the rate observed in the normally-conceived Spanish population. Multiplicity seems to be the most important factor associated with an increased incidence of newborn complications such as prematurity or stillbirth.Keywords ART . Pregnancy outcome . Perinatal outcome . Malformations . Prematurity . StillbirthCapsule This report examines the impact of Assisted Reproductive Techniques (ART) on malformation in Spain. Malformations were found in 0.83 % of newborns, similar to levels in the general Spanish birth population.

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Section: Discussionsupporting

confidence: 76%

Impact of assisted reproduction treatments on Spanish newborns: report of 14,119 pregnancies

Ricciarelli¹,

Bruna

Verdú³

et al. 2013

J Assist Reprod Genet

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“…Numerous studies have indicated that children conceived through ART are at a significantly elevated risk of birth defects (Rimm et al, 2004;Bower and Hansen, 2005;Hansen et al, 2005;Olivennes, 2005;Schieve et al, 2005;Bertelsmann et al, 2008;El-Chaar et al, 2009;Goel et al, 2009;Tararbit et al, 2011;Davies et al, 2012;Mozafari Kermani et al, 2012;Wen et al, 2012). Meta-analyses have shown a 30%-40% increase in the major malformation rates for infants conceived through ART compared with NC children (Rimm et al, 2004;Hansen et al, 2005;Wen et al, 2012).…”

Section: Birth Defectsmentioning

confidence: 99%

Long-term follow-up of children conceived through assisted reproductive technology

Wang

Jin

2013

J. Zhejiang Univ. Sci. B

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Children conceived via assisted reproductive technologies (ART) are nowadays a substantial proportion of the population. It is important to follow up these children and evaluate whether they have elevated health risks compared to naturally conceived (NC) children. In recent years there has been a lot of work in this field. This review will summarize what is known about the health of ART-conceived children, encompassing neonatal outcomes, birth defects, growth and gonadal developments, physical health, neurological and neurodevelopmental outcomes, psychosocial developments, risk for cancer, and epigenetic abnormalities. Most of the children conceived after ART are normal. However, there is increasing evidence that ART-conceived children are at higher risk of poor perinatal outcome, birth defects, and epigenetic disorders, and the mechanism(s) leading to these changes have not been elucidated. Continuous follow-up of children after ART is of great importance as they progress through adolescence into adulthood, and new ART techniques are constantly being introduced.

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“…However, the IVF procedure has known concerns including multiple pregnancies, ovarian hyperstimulation, 11,12 an associated higher incidence of preterm birth, low birth weight, intrauterine growth restriction, and congenital malformations. 13 Therefore, there may still be a continuing role for tubal reversal surgery for those who desire fertility after sterilization. Furthermore, current efforts to avoid multiple births by transferring fewer embryos may further limit the live birth rate associated with IVF, making the higher success rate of tubal anastomosis even more attractive.…”

Section: Discussionmentioning

confidence: 99%

Single-Port Laparoscopic Tubal Anastomosis

Kim¹,

Jeong²

2014

CRSLS

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Risk of birth defects increased in pregnancies conceived by assisted human reproduction

Cited by 83 publications

References 32 publications

Impact of assisted reproduction treatments on Spanish newborns: report of 14,119 pregnancies

Impact of assisted reproduction treatments on Spanish newborns: report of 14,119 pregnancies

Long-term follow-up of children conceived through assisted reproductive technology

Single-Port Laparoscopic Tubal Anastomosis

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