Risk for cancer in living kidney donors and recipients

Wang, Min; Zhang, Huai; Zhou, Dan; Qiao, Yong-Chao; Wang, Yanchao; Zhao, Hai-Lu

doi:10.1007/s00432-018-2590-z

Cited by 3 publications

(2 citation statements)

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“…It is suggested that the safety of kidney donation should be carried out by long-term follow-up. In a recent study, Wang et al reported that RT is associated with an increased risk of cancer during long-term follow-up (36). Mortality data from the United States and other countries have identified cancer as the leading cause of death among living renal donors.…”

Section: Discussionmentioning

confidence: 99%

The Alteration of Pro-inflammatory Cytokines and Oxidative Stress Markers at Six-Month Post-living Kidney Donation

et al. 2020

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Donors have a higher risk of developing chronic kidney disease than the general population. Some mechanisms mediated by pro-inflammatory cytokines and oxidative stress may be involved as risk factors. The objective of the study was to evaluate the behavior of pro-inflammatory cytokines and oxidative stress markers in living renal donors with a 6-month follow-up. A single prospective cohort was performed in 88 renal donors. At the end of the follow-up, the levels of lipoperoxides, 6.52 ± 1.12 mM, and 8-isoprostanes, 63.75 ± 13.28 pg/mL, were lower than before donation, 10.20 ± 3.95 mM (p < 0.001) and 67.54 ± 9.64 pg/mL (p = 0.026), respectively. Initial levels of nitric oxide (NO), 356.09 ± 59.38 µM increased at the end of the follow-up, 467.08 ± 38.74 µM (p < 0.001). It was observed in the final determination of donors decreased activity of antioxidant enzymes superoxide dismutase (SOD), 0.74 ± 0.57 U/L and glutathione peroxidase (GPx), 556.41 ± 80.37 nmol, in comparison with the levels obtained in the initial determination, 1.05 ± 0.57 U/L (p < 0.001) and 827.93 ± 162.78 nmol (p < 0.001), respectively. The pro-inflammatory cytokines, Tumor necrosis factor alpha and interleukin-6 showed no differences at 6 months after donation. The enzyme oxoguanine glycosylase (hOGG1) responsible for repairing oxidative damage to DNA, showed a decrease in its concentration at the end of the study in donor men, 0.40 ± 0.21 ng/mL compared to the initial levels, 0.55 ± 0.32 ng/mL (p = 0.025). The marker, 8-hydroxy-2-deoxyguanosine (8-OHdG) exhibited an increase in donor men at the final determination 2.28 ± 1.99 ng/mL, compared to the concentration before donation, 1.72 ± 1.96 ng/mL (p < 0.001). We found significant changes in the markers of the oxidative state with increased NO and 8-OHdG, as well as a significant decrease in the antioxidant defenses SOD, GPx, and in the DNA repair enzyme in living renal donors after 6 months of follow-up.

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Section: Discussionmentioning

confidence: 99%

The Alteration of Pro-inflammatory Cytokines and Oxidative Stress Markers at Six-Month Post-living Kidney Donation

et al. 2020

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“…Diet has been implicated in long-term health outcomes in living kidney donors. A systematic review and meta-analysis of eight studies revealed that living kidney donors had 2.8 times greater odds of incidence of malignancy compared to nondonors after a follow-up between 18 months and 20 years [23]. A recent large retrospective cohort study using the Scientific Registry of Transplant Recipients (SRTR) linked with Surveillance, Epidemiology, and End Results (SEER) registry data revealed that the incidence of colorectal and kidney cancers were up to 2 and 3 times greater in living kidney donors compared to Adventist Health Study-2 (AHS-2) participants, respectively [24 ▪▪ ].…”

Section: Prevention For Declined Kidney Function Of the Donormentioning

confidence: 99%

Paradigm shift in lifestyle modification for solitary kidney after donor nephrectomy

Tantisattamo

Kalantar‐Zadeh

2022

Current Opinion in Nephrology &Amp; Hypertension

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Purpose of review Living donor kidney transplantation potentially leads to long-term complications including chronic kidney disease, end-stage kidney disease, elevated blood pressure, and pregnancy-associated hypertension. Given living donors generally do not have underlying medical conditions, lifestyle modifications, particularly dietary interventions may prevent those complications and improve their health outcomes. Recent findings Glomerular hyperfiltration occurs as physiologic adaptation during an initial postdonor nephrectomy period. In the long-term, these adaptations may become pathologic consequences resulting from hyperfiltration-mediated kidney injury and ultimately secondary focal segmental glomerulosclerosis in the solitary kidney. Dietary interventions to slow a decline in kidney function include low protein intake of <0.8 g/kg/day and low sodium consumption of 2–4 g/day as well as certain health dietary patterns. There is no evidence regarding the quantity and quality of protein that can be recommended for living kidney donors and the same for sodium. Plant Dominant (PLADO) diets, Dietary Approaches to Stop Hypertension (DASH), Mediterranean, and vegetarian diets may be favorable for living kidney donors with solitary kidney but the evidence is still lacking. Summary Although dietary interventions may provide benefits and kidney health for living kidney donors, further studies including clinical trials are required to incorporate them into clinical practice guidelines.

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Kidney transplantation: the recipient

2024

Living Donor Organ Transplantation

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Risk for cancer in living kidney donors and recipients

Abstract: Kidney transplantation was associated with an increased risk of cancer during a long-term follow-up. Long-term risk for cancer in LKDs and kidney recipients should be monitored.

Cited by 3 publications

References 50 publications

The Alteration of Pro-inflammatory Cytokines and Oxidative Stress Markers at Six-Month Post-living Kidney Donation

The Alteration of Pro-inflammatory Cytokines and Oxidative Stress Markers at Six-Month Post-living Kidney Donation

Paradigm shift in lifestyle modification for solitary kidney after donor nephrectomy

Kidney transplantation: the recipient

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