Risk factors predisposing to acute coronary syndromes in young women ≤45 years of age

Bęćkowski, Maciej; Gierlotka, Marek; Gąsior, Mariusz; Poloński, Lech; Zdrojewski, Tomasz; Dąbrowski, Rafał; Karwowski, Jarosław; Kowalik, Ilona; Drygas, Wojciech; Szwed, Hanna

doi:10.1016/j.ijcard.2018.03.135

Cited by 23 publications

(33 citation statements)

References 23 publications

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“…Although smoking, hyperlipidaemia and obesity are crucial among the risk factors for MI at a young age, there are some differences in their distribution between particular groups of patients [25,26]. For example, the strongest predictor of ACS in women ≤45 years of age was diabetes, with a 6-fold increase in risk [27]. Our study confirmed the significance of smoking, dyslipidaemia, obesity and carbohydrate metabolism disturbances as CAD risk factors.…”

Section: Discussionsupporting

confidence: 82%

Younger age of patients with myocardial infarction is associated with a higher number of relatives with a history of premature atherosclerosis

Ambroziak

Niewczas-Wieprzowska

Maicka

et al. 2020

BMC Cardiovasc Disord

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Background Premature coronary artery disease is one of the most pressing global issues in modern cardiology. The aim of the study was to investigate the role of family history of premature cardiovascular disease (CVD) in patients aged < 50 years with myocardial infarction (MI) compared to that in patients aged ≥50 years with MI and to that in young people without MI (no-MI < 50). Methods The studied group (MI < 50) consisted of 240 patients aged 26–49 years with MI. The control groups consisted of 240 patients (MI ≥ 50) with MI aged 50–92 years and 240 healthy people aged 30–49 years without a history of MI (no-MI < 50). Results There were statistically significant differences between the MI < 50 and MI ≥ 50 and no-MI < 50 groups regarding the family history of premature MI/ischaemic stroke and the percentage of patients with ≥2 relatives affected (10.8, 2.9, and 3.7%, respectively; p < 0.0001). There was a statistically significant difference in the patient age at the first MI occurrence among patients without a family history of premature CVD, those with 1 affected relative, and those with ≥2 affected first-degree relatives (56.6, 48.6 and 41.8 years, respectively) as well as those with affected first- and second-degree relatives (56.5, 50.7 and 47.0 years, respectively). Conclusions A younger age of patients with myocardial infarction is associated with a higher number of relatives with a history of premature MI/ischaemic stroke. Thus, the family history of premature atherosclerosis involving not only first- but also second-degree relatives seems to be a valuable factor in CVD risk evaluation in young people. Graphical Abstract

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Section: Discussionsupporting

confidence: 82%

Younger age of patients with myocardial infarction is associated with a higher number of relatives with a history of premature atherosclerosis

Ambroziak

Niewczas-Wieprzowska

Maicka

et al. 2020

BMC Cardiovasc Disord

View full text Add to dashboard Cite

show abstract

“…Although smoking, hyperlipidaemia and obesity are crucial among the risk factors for MI at a young age, there are some differences in their distribution between particular groups of patients [25,26]. For example, the strongest predictor of ACS in women ≤45 years of age was diabetes, with a 6-fold increase in risk [27]. Our study con rmed the signi cance of smoking, dyslipidaemia, obesity and carbohydrate metabolism disturbances as CAD risk factors.…”

Section: Discussionsupporting

confidence: 70%

Younger age of patients with myocardial infarction is associated with a higher number of relatives with a history of premature atherosclerosis.

Ambroziak¹,

Niewczas-Wieprzowska²,

Maicka³

et al. 2020

Preprint

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Background. Premature coronary artery disease is one of the most pressing global issues in modern cardiology. The aim of the study was to investigate the role of family history of premature cardiovascular disease (CVD) in patients aged <50 years with myocardial infarction (MI) compared to that in patients aged ≥50 years with MI and to that in young people without MI (no-MI<50). Methods. The studied group (MI<50) consisted of 240 patients aged 26-49 years with MI. The control groups consisted of 240 patients (MI≥50) with MI aged 50-92 years and 240 healthy people aged 30-49 years without a history of MI (no-MI<50). Results. There were statistically significant differences between the MI<50 and MI≥50 and no-MI<50 groups regarding the family history of premature MI/ischaemic stroke and the percentage of patients with ≥2 relatives affected (10.8%, 2.9%, and 3.7%, respectively; p<0.0001). There was a statistically significant difference in the patient age at the first MI occurrence among patients without a family history of premature CVD, those with 1 affected relative, and those with ≥2 affected first-degree relatives (56.6, 48.6 and 41.8 years, respectively) as well as those with affected first- and second-degree relatives (56.5, 50.7 and 47.0 years, respectively). Conclusions. A younger age of patients with myocardial infarction is associated with a higher number of relatives with a history of premature MI/ischaemic stroke. Thus, the family history of premature atherosclerosis involving not only first- but also second-degree relatives seems to be a valuable factor in CVD risk evaluation in young people.

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“…Although the contribution of various risk factors to the development of acute coronary syndrome (ACS) has been extensively analyzed, women younger than 50 years old have rarely been included in clinical trials. Nevertheless, the effect of traditional risk factors have also been confirmed in this population: hypertension, smoking, and hyperlipidemia appear to have a high impact on the development of ACS in women [ 5 ], all of which were present in our patient.…”

Section: Discussionsupporting

confidence: 58%

Limitations of Coronary Computed Tomography Angiography in Predicting Acute Coronary Syndrome in a Low to Intermediate-risk Patient with Chest Pain

Zaghloul

Iorgoveanu

Balakumaran

et al. 2018

Cureus

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The optimal management of patients with chest pain relies on the prognostic information provided by noninvasive cardiovascular testing. Coronary computed tomography angiography (CCTA) is an increasingly utilized, highly accurate noninvasive test for diagnosing coronary artery disease. We illustrate an exceptional limitation of the prognostic information provided by CCTA. A 46-year-old female presented with chest pain suggestive of angina. Noninvasive testing for ischemia was negative, with CCTA showing mild stenosis of the proximal left anterior descending (LAD) artery. An electrocardiogram after two weeks demonstrated ST elevation in leads V1-V2 and aVR, with ST depression in the lateral leads. Cardiac catheterization revealed a significant proximal LAD lesion requiring percutaneous coronary intervention. An anatomic assessment of coronary arteries should be considered in cases of strong clinical suspicion for cardiac ischemia and initial nondiagnostic findings. Further studies are needed to improve the accuracy and the negative predictive value of CCTA in intermediate-risk individuals.

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Risk factors predisposing to acute coronary syndromes in young women ≤45 years of age

Cited by 23 publications

References 23 publications

Younger age of patients with myocardial infarction is associated with a higher number of relatives with a history of premature atherosclerosis

Younger age of patients with myocardial infarction is associated with a higher number of relatives with a history of premature atherosclerosis

Younger age of patients with myocardial infarction is associated with a higher number of relatives with a history of premature atherosclerosis.

Limitations of Coronary Computed Tomography Angiography in Predicting Acute Coronary Syndrome in a Low to Intermediate-risk Patient with Chest Pain

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Risk factors predisposing to acute coronary syndromes in young women ≤45 years of age

Cited by 23 publications

References 23 publications

Younger age of patients with myocardial infarction is associated with a higher number of relatives with a history of premature atherosclerosis

Younger age of patients with myocardial infarction is associated with a higher number of relatives with a history of premature atherosclerosis

Younger age of patients with myocardial infarction is associated with a higher number of relatives with a history of premature atherosclerosis.

Limitations of Coronary Computed Tomography Angiography in Predicting Acute Coronary Syndrome in a Low to Intermediate-risk Patient with Chest Pain

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Risk factors predisposing to acute coronary syndromes in young women ≤45 years of age