2020
DOI: 10.3390/jcm9123817
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Abstract: Hepatocellular carcinoma (HCC) is a leading cause of cancer-associated mortality globally. Given the limited therapeutic efficacy in advanced HCC, prevention of HCC carcinogenesis could serve as an effective strategy. Patients with chronic fibrosis due to viral or metabolic etiologies are at a high risk of developing HCC. Primary prevention seeks to eliminate cancer predisposing risk factors while tertiary prevention aims to prevent HCC recurrence. Secondary prevention targets patients with baseline chronic li… Show more

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Cited by 26 publications
(21 citation statements)
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References 273 publications
(275 reference statements)
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“…Probably one of the most frequently occurring types of cancer is HCC and its prevalence has continued to rise in recent years (21). A series of steps are involved in the development of cancer cells which involve changes in growth, cell metabolism, proliferation, and adhesion (22,23). Several studies have provided information about the biomarker of liver cancer (24,25).…”
Section: Discussionmentioning
confidence: 99%
“…Probably one of the most frequently occurring types of cancer is HCC and its prevalence has continued to rise in recent years (21). A series of steps are involved in the development of cancer cells which involve changes in growth, cell metabolism, proliferation, and adhesion (22,23). Several studies have provided information about the biomarker of liver cancer (24,25).…”
Section: Discussionmentioning
confidence: 99%
“…e incidence of liver cancer varies geographically, with the majority of liver cancer cases occurring in less developed regions, such as East Asia (54.8% of cases) and Southeast Asia (10.8% of cases) [29]. From 2006 to 2017, the incidence of HCC increased by 2-3% per year, mainly due to viral cirrhosis and a high incidence of NAFLD [30].…”
Section: Epidemiology Of Hccmentioning
confidence: 99%
“…Hepatitis C virus (HCV) infection is the main leading etiology of hepatocellular carcinoma in Europe, North America, and Japan. Emerging risk factors for HCC development such as NASH, type 2 diabetes mellitus, and obesity may determine a synergistic or an independent risk [ 23 ].…”
Section: Discussionmentioning
confidence: 99%